EGFR, epidermal growth factor receptor, 1956

N. diseases: 1394; N. variants: 183
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0018671
Disease: Head and Neck Neoplasms
Head and Neck Neoplasms
0.630 Biomarker group BEFREE The EGFR-targeted doxorubicin-loaded PLGA/PD NP effectively eradicate head and neck tumor in vivo through the synergism of photothermal therapy and chemotherapy while not introducing doxorubicin associated cardiotoxicity. 28688985 2017
CUI: C0018671
Disease: Head and Neck Neoplasms
Head and Neck Neoplasms
0.630 GeneticVariation group CLINVAR Epidermal Growth Factor Receptor P753S Mutation in Cutaneous Squamous Cell Carcinoma Responsive to Cetuximab-Based Therapy. 24934779 2016
CUI: C0018671
Disease: Head and Neck Neoplasms
Head and Neck Neoplasms
0.630 GeneticVariation group CLINVAR A patient-derived somatic mutation in the epidermal growth factor receptor ligand-binding domain confers increased sensitivity to cetuximab in head and neck cancer. 23578570 2013
CUI: C0018671
Disease: Head and Neck Neoplasms
Head and Neck Neoplasms
0.630 Biomarker group CTD_human NOX4 mediates cytoprotective autophagy induced by the EGFR inhibitor erlotinib in head and neck cancer cells. 23917044 2013
CUI: C0018671
Disease: Head and Neck Neoplasms
Head and Neck Neoplasms
0.630 GeneticVariation group CLINVAR Screening for EGFR Mutations in Patients with Head and Neck Cancer Treated with Gefitinib on a Compassionate-Use Program: A Hellenic Cooperative Oncology Group Study. 21274259 2010
CUI: C0018671
Disease: Head and Neck Neoplasms
Head and Neck Neoplasms
0.630 PosttranslationalModification group BEFREE Heparanase augments epidermal growth factor receptor phosphorylation: correlation with head and neck tumor progression. 19074873 2008
CUI: C0018671
Disease: Head and Neck Neoplasms
Head and Neck Neoplasms
0.630 AlteredExpression group LHGDN Alteration of the serum levels of the epidermal growth factor receptor and its ligands in patients with non-small cell lung cancer and head and neck carcinoma. 17453000 2007
CUI: C0018671
Disease: Head and Neck Neoplasms
Head and Neck Neoplasms
0.630 Biomarker group CTD_human SRC family kinases mediate epidermal growth factor receptor ligand cleavage, proliferation, and invasion of head and neck cancer cells. 15342401 2004
CUI: C0018671
Disease: Head and Neck Neoplasms
Head and Neck Neoplasms
0.630 Biomarker group CTD_human Epidermal growth factor receptor-targeted therapy potentiates lovastatin-induced apoptosis in head and neck squamous cell carcinoma cells. 12942316 2003
CUI: C0018671
Disease: Head and Neck Neoplasms
Head and Neck Neoplasms
0.630 CausalMutation group CGI