A2M, alpha-2-macroglobulin, 2

N. diseases: 147; N. variants: 3
Disease: Alzheimer Disease, Late Onset ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0494463
Disease: Alzheimer Disease, Late Onset
Alzheimer Disease, Late Onset 		0.370 GeneticVariation disease BEFREE Moreover, little is known regarding the effects of polymorphisms in A2M promoter region on AD susceptibility. 20493925 2010
CUI: C0494463
Disease: Alzheimer Disease, Late Onset
Alzheimer Disease, Late Onset 		0.370 GeneticVariation disease BEFREE Variants of the interleukin-6, bleomycin hydrolase and alpha(2)-macroglobulin genes did not significantly influence the (age-adjusted) risk of AD in relatives. 15211070 2004
CUI: C0494463
Disease: Alzheimer Disease, Late Onset
Alzheimer Disease, Late Onset 		0.370 Biomarker disease CTD_human Increased risk for Alzheimer disease with the interaction of MPO and A2M polymorphisms. 15023809 2004
CUI: C0494463
Disease: Alzheimer Disease, Late Onset
Alzheimer Disease, Late Onset 		0.370 GeneticVariation disease BEFREE Our data do not support a role for the A2M gene as genetic risk factor for AD. 11166925 2001
CUI: C0494463
Disease: Alzheimer Disease, Late Onset
Alzheimer Disease, Late Onset 		0.370 GeneticVariation disease BEFREE Alpha-1 antichymotrypsin and alpha-2 macroglobulin gene polymorphisms are not associated with Korean late-onset Alzheimer's disease. 11290389 2001
CUI: C0494463
Disease: Alzheimer Disease, Late Onset
Alzheimer Disease, Late Onset 		0.370 GeneticVariation disease BEFREE In our present study, we were unable to corroborate the association between A2M intronic polymorphism and LOAD in autopsy cases. 10505652 1999
CUI: C0494463
Disease: Alzheimer Disease, Late Onset
Alzheimer Disease, Late Onset 		0.370 GeneticVariation disease BEFREE Association between an alpha(2) macroglobulin DNA polymorphism and late-onset Alzheimer's disease. 10527839 1999
CUI: C0494463
Disease: Alzheimer Disease, Late Onset
Alzheimer Disease, Late Onset 		0.370 GeneticVariation disease BEFREE However, they do not exclude the possibility that an AD susceptibility allele is located elsewhere in A2M or a nearby gene. 10477119 1999
CUI: C0494463
Disease: Alzheimer Disease, Late Onset
Alzheimer Disease, Late Onset 		0.370 Biomarker disease CTD_human Alpha-2 macroglobulin is genetically associated with Alzheimer disease. 9697696 1998
CUI: C0494463
Disease: Alzheimer Disease, Late Onset
Alzheimer Disease, Late Onset 		0.370 Biomarker disease CTD_human Genetic association of an alpha2-macroglobulin (Val1000lle) polymorphism and Alzheimer's disease. 9811940 1998