EPO, erythropoietin, 2056

N. diseases: 646; N. variants: 11
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0035078
Disease: Kidney Failure
Kidney Failure
0.360 Biomarker disease BEFREE The main reason for anemia in renal failure patients is the insufficient erythropoietin production by the kidneys. 28747155 2017
CUI: C0035078
Disease: Kidney Failure
Kidney Failure
0.360 Biomarker disease BEFREE We show that even mild renal failure blunts erythropoietin production and propose the HBS1L-MYB locus as a regulator of erythropoietin. 25915923 2015
CUI: C0035078
Disease: Kidney Failure
Kidney Failure
0.360 Therapeutic disease CTD_human Protective effect of recombinant human erythropoietin against cisplatin-induced oxidative stress and nephrotoxicity in rat kidney. 22013135 2011
CUI: C0035078
Disease: Kidney Failure
Kidney Failure
0.360 Biomarker disease BEFREE Despite the decrease in creatinine clearance (95.1 to 66.9 ml/min, p < 0.001), a similar median O/E Epo level was observed, independently of the presence of renal failure, excluding an important impact of renal failure on Epo production. 17453623 2007
CUI: C0035078
Disease: Kidney Failure
Kidney Failure
0.360 Biomarker disease BEFREE Patients with chronic renal insufficiency (CRI) have reduced hemoglobin levels, mostly as a result of decreased kidney production of erythropoietin, but the relation between renal insufficiency and the magnitude of hemoglobin reduction has not been well defined. 16138214 2005
CUI: C0035078
Disease: Kidney Failure
Kidney Failure
0.360 Biomarker disease BEFREE Low Epo values were observed independently of the presence of renal failure or anemia, and sometimes preceded clinical disease. 15496172 2004
CUI: C0035078
Disease: Kidney Failure
Kidney Failure
0.360 Biomarker disease BEFREE The results demonstrate that myoblasts can be transplanted in uremic mice, and that myoblast gene transfer can achieve sufficient and sustained delivery of functionally active EPO to correct anemia associated with renal failure in mice. 7706487 1995