ERBB3, erb-b2 receptor tyrosine kinase 3, 2065

N. diseases: 318; N. variants: 16
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.350 GeneticVariation group BEFREE Interestingly, acute loss of Erbb3 suppressed further growth of established EGFR(L858R)-mediated lung tumors. 25596284 2015
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.350 AlteredExpression group BEFREE We show that the NTS autocrine and/or paracrine regulation causes EGFR, HER2, and HER3 over-expression and activation in lung tumor cells. 25249545 2014
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.350 AlteredExpression group LHGDN MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling. 17463250 2007
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.350 Biomarker group LHGDN Pertuzumab, a novel HER dimerization inhibitor, inhibits the growth of human lung cancer cells mediated by the HER3 signaling pathway. 17627612 2007
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.350 Biomarker group CTD_human Lung tumorigenesis associated with erb-B-2 and erb-B-3 overexpression in human erb-B-3 transgenic mice is enhanced by methylnitrosourea. 12483526 2002
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.350 AlteredExpression group LHGDN Lung tumorigenesis associated with erb-B-2 and erb-B-3 overexpression in human erb-B-3 transgenic mice is enhanced by methylnitrosourea. 12483526 2002