ERBB3, erb-b2 receptor tyrosine kinase 3, 2065

N. diseases: 318; N. variants: 16
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma
0.400 AlteredExpression disease BEFREE ErbB1 and ErbB3 expressions were analyzed by immunohistochemistry and real-time PCR in 50 patients with gastric cancer. 30621788 2019
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma
0.400 Biomarker disease BEFREE Resistance is reverted by simultaneous inhibition of EGFR, HER2, and HER3, thereby revealing a potential therapeutic strategy to overcome trastuzumab resistance in patients with gastric cancer. 31484705 2019
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma
0.400 AlteredExpression disease BEFREE We found that high ERBB3 gene expression correlates with decreased survival in the intestinal type of gastric cancer. 30726523 2019
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma
0.400 Biomarker disease BEFREE In this study, we evaluated prevalence of Her3 in gastric cancer, in a Saudi cohort of cases, along with its association with prognostic markers p53 and Ki-67. 30915908 2019
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma
0.400 AlteredExpression disease BEFREE However, the prognostic value of HER2-HER3 overexpression remains unknown in gastric cancer (GC). 29233126 2017
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma
0.400 Biomarker disease BEFREE We evaluated the expression levels of various ERBB receptor ligands (i.e., heparin-binding epidermal growth factor-like growth factor [HBEGF], transforming growth factor-α [TGFA], amphiregulin [AREG], epiregulin [EREG], epidermal growth factor [EGF], and betacellulin [BTC]) and 3 ERBB family receptors (i.e., epidermal growth factor receptor [EGFR], human EGFR2 [HER2], and ERBB3) in 313 cases of GC using immunohistochemistry, fluorescence in situ hybridization, and mRNA in situ hybridization. 28399526 2017
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma
0.400 GeneticVariation disease BEFREE Besides, SNP rs3202538 (G/T) in ErbB3 3'-UTR was involved in the occurrence of GC by acting as tumor risk factors. 28924391 2017
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma
0.400 Biomarker disease BEFREE A phase I open-label dose-escalation study of the anti-HER3 monoclonal antibody LJM716 in patients with advanced squamous cell carcinoma of the esophagus or head and neck and HER2-overexpressing breast or gastric cancer. 28899363 2017
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma
0.400 Biomarker disease BEFREE Importantly, we identified EHF as a new HER2 transcription factor and the modulator of HER3 and HER4 in gastric cancer. 27787520 2016
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma
0.400 Biomarker disease BEFREE Our findings offer compelling evidence that APIP plays an essential role in ERBB3 signaling as a positive regulator for tumorigenesis, warranting future development of therapeutic strategies for ERBB3-driven gastric cancer. 26942872 2016
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma
0.400 Biomarker disease BEFREE In conclusion, various molecular transduction patterns: Her2/Her3 and Met/Her3 were verified in human GC, and Her3 could serve as a potential target in GC treatment. 25400108 2015
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma
0.400 Biomarker disease BEFREE Thus, of the RTKs studied, HER3 was the only RTK identified as an independent prognostic indicator of stage II/III advanced gastric cancer with standard treatment. 25455899 2014
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma
0.400 Biomarker disease BEFREE Nuclear YB-1 expression was significantly (P = 0.026) associated with HER2 expression, but not with EGFR or HER3, in patients with gastric cancer (n = 111). 23445612 2013
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma
0.400 Biomarker disease BEFREE ErbB3 was found to be phosphorylated selectively in dedifferentiated adenocarcinoma cell lines among various gastric cancer cell lines. 12618754 2003
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma
0.400 CausalMutation disease CGI