Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0025202
Disease: melanoma
melanoma
0.350 AlteredExpression disease BEFREE TOP2A expression was increased in brain metastases from all 3 cancers, and brain metastases overexpressed multiple proteins clustering around functions critical to DNA synthesis and repair and implicated in chemotherapy resistance, including RRM1, TS, ERCC1 and TOPO1. cMET was overexpressed in melanoma brain metastases relative to primary skin specimens. 29923182 2018
CUI: C0025202
Disease: melanoma
melanoma
0.350 Biomarker disease BEFREE We have previously validated ERCC1 as a therapeutic target in melanoma, but all small molecule ERCC1-XPF inhibitors reported to date have lacked sufficient potency and specificity for clinical use. 28903417 2017
CUI: C0025202
Disease: melanoma
melanoma
0.350 Biomarker disease BEFREE The DNA repair proteins ERCC1 and XPF are needed to remove cisplatin-induced DNA damage and we have investigated the response of these proteins to cisplatin in melanoma. 21996734 2012
CUI: C0025202
Disease: melanoma
melanoma
0.350 Biomarker disease BEFREE Untreated xenografts of our transformed Ercc1-proficient melanocyte cell line grew very rapidly as malignant melanoma. 21722328 2011
CUI: C0025202
Disease: melanoma
melanoma
0.350 Biomarker disease CTD_human However, in xenografts, the Ercc1-deficient melanomas were much slower to establish and were completely cured by just two cisplatin treatments. 21722328 2011
CUI: C0025202
Disease: melanoma
melanoma
0.350 GeneticVariation disease BEFREE Significant associations were found for the NER genes ERCC1 and XPF, with the strongest associations for melanoma cases aged 50 and under [ERCC1 odds ratio (OR) 1.59, P = 0.008; XPF OR 1.69, P = 0.003]. 17210993 2007