|
Squamous cell carcinoma of tongue
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We have demonstrated that the overexpression of TFIIH correlates positively with node metastasis, while XPF correlates negatively with node metastasis; therefore, the expression of XPF and TFIIH had a potential value for predicting the progression of OTSCC patients.
|
31828418 |
2020 |
|
ABLEPHARON-MACROSTOMIA SYNDROME
|
0.010 |
Biomarker
|
disease |
BEFREE |
Second, the targets of DZ were predicted using the SwissTargetPrediction and STITCH databases; the targets of AMS were also collected from the Drugbank and TTD databases.
|
31835126 |
2020 |
|
Developmental Disabilities
|
0.010 |
GeneticVariation
|
group |
BEFREE |
Remarkably, these early transcriptional events are affected by TFIIE and TFIIH mutations associated with the developmental disorder, trichothiodystrophy.
|
31064989 |
2019 |
|
Endometriosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
This study suggests that certain single nucleotide polymorphisms of nucleotide excision repair genes excision repair cross-complementation group 1 (ERCC1, ERCC2, and ERCC6) predispose women to the development of endometriosis.
|
31373346 |
2019 |
|
Retinoblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Studies from Latin America and the Caribbean, published between 1997 and 2017, reporting TTD and age at diagnosis of patients with retinoblastoma were selected.
|
31014139 |
2019 |
|
Malignant neoplasm of stomach stage IV
|
0.010 |
Biomarker
|
disease |
BEFREE |
ERCC1 and ERCC2 overexpression are promising predictive biomarkers for patients with locally advanced or metastatic GC receiving neoadjuvant mFOLFOX-4 chemotherapy and the potential clinical implication is mandatory for further investigation.
|
31077069 |
2019 |
|
Sleeplessness
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
GC-MS was used to detect the chemical composition of Compound Anshen essential oil, and the TCMSP, STITCH, TTD, and DrugBank databases were searched to predict and screen the targets of Compound Anshen essential oil in the treatment of insomnia.
|
31275424 |
2019 |
|
Tumor Cell Invasion
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
The aim of this study was to investigate the role of XPD in migration and invasion of hepatocellular carcinoma (HCC) cells.
|
30627419 |
2019 |
|
Carcinoma of urinary bladder, invasive
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
In a separate genomic analysis, we detected significantly more likely deleterious somatic ERCC2 missense mutations in primary MIBC tumors in both the discovery (10.9% [36/330] vs 1.8% [1/55], p=0.04) and the validation (15.7% [12/70] vs 0% [0/24], p=0.03) cohort.
|
30290956 |
2019 |
|
Hyponatremia
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
Two polymorphisms were independently associated with the development of severe hyponatremia among patients carrying the minor allele (vs. patients with major homozygote genotype): TYMS 3'-UTR rs151264360 (odds ratio, 3.64; 95% confidence interval, 1.11-11.9) and XPD rs13181" genes_norm="2068">Lys751Gln rs13181 (odds ratio, 10.1; 95% confidence interval, 1.10-93.3).
|
30214618 |
2018 |
|
Nephroblastoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The XPD rs3810366 polymorphism significantly enhanced Wilms tumor risk (dominant model: adjusted OR = 2.12, 95% CI = 1.26-3.57).
|
30161024 |
2018 |
|
Intrahepatic Cholangiocarcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
A panel of 12 genes (e.g., HSP90β, ERG1, GPC3, TKT, ACLY, and NME1 for HCC; SPT2, T4S3, CNX43, TTD1, HBD01 for CC) were detected and partly described for the first time as potential discrimination markers.
|
29271183 |
2018 |
|
Motor symptoms
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Pallidal DBS represents an important treatment option for XPD for the management of motor symptoms.
|
30481788 |
2018 |
|
Malignant Squamous Cell Neoplasm
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The aim of the study is to investigate the relation between XPG and XPD gene variants in the DNA repair system and oral squamous cell cancers.
|
30672443 |
2018 |
|
Childhood Kidney Wilms Tumor
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The XPD rs3810366 polymorphism significantly enhanced Wilms tumor risk (dominant model: adjusted OR = 2.12, 95% CI = 1.26-3.57).
|
30161024 |
2018 |
|
Hereditary Nonpolyposis Colorectal Cancer
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our findings revealed that polymorphisms of DNA repair genes that include NUDT1, ERCC2, and MUTYH are associated with CRC in patients with Lynch syndrome in Chinese population.
|
29664240 |
2018 |
|
Primary cholangiocarcinoma of intrahepatic biliary tract
|
0.010 |
Biomarker
|
disease |
BEFREE |
A panel of 12 genes (e.g., HSP90β, ERG1, GPC3, TKT, ACLY, and NME1 for HCC; SPT2, T4S3, CNX43, TTD1, HBD01 for CC) were detected and partly described for the first time as potential discrimination markers.
|
29271183 |
2018 |
|
Lynch Syndrome
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our findings revealed that polymorphisms of DNA repair genes that include NUDT1, ERCC2, and MUTYH are associated with CRC in patients with Lynch syndrome in Chinese population.
|
29664240 |
2018 |
|
progesterone receptor-negative breast cancer
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
ERCC2-rs1799793-AA genotype correlated with ER+ and PR+ breast cancer.
|
29544444 |
2018 |
|
progesterone receptor-positive breast cancer
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
ERCC2-rs1799793-AA genotype correlated with ER+ and PR+ breast cancer.
|
29544444 |
2018 |
|
Nasal Polyps
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
In addition, when we stratified ERCC2, ERCC3 and XRCC1 polymorphism genotypes by the median and 75th percentiles of blood-Cd levels, we found also significant interactions between ERCC2 (Lys751Gln) and ERCC3 (7122 A>G) genotypes polymorphism and this metal in association with NP disease.
|
27838878 |
2017 |
|
Nausea
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
Patients with XPC c.2815AC or CC and XPD c.934GA or AA genotypes had 0.20 and 0.38 less chances of presenting moderate/severe ototoxicity and nausea, respectively.
|
26918827 |
2017 |
|
Obsessive-Compulsive Disorder
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
XPD Gln+ frequencies were higher in the controls than in the patients, and carriers of the Gln+ genotype showed decreased levels of OCD risk (p < 0.001).
|
29264886 |
2017 |
|
Polycystic Ovary Syndrome
|
0.010 |
Biomarker
|
disease |
BEFREE |
The Investigation of Polymorphisms in DNA Repair Genes (XRCC1, APE1 and XPD) in Women with Polycystic Ovary Syndrome
|
28610405 |
2017 |
|
Vomiting
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
GSTP1 c.313A>G, XPD c.934G>A, XPF c.2505T>C and CASP9 c.-1339A>G Polymorphisms and Severity of Vomiting in Head and Neck Cancer Patients treated with Cisplatin Chemoradiation.
|
28686330 |
2017 |