Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0585442
Disease: Osteosarcoma of bone
Osteosarcoma of bone
0.100 GeneticVariation disease BEFREE Genetic polymorphisms of ERCC-1 and ERCC-2 are not prognostic markers in osteosarcoma patients with chemotherapy: A meta-analysis in Chinese population. 30544402 2018
CUI: C0585442
Disease: Osteosarcoma of bone
Osteosarcoma of bone
0.100 GeneticVariation disease BEFREE The ERCC2 rs1799793 polymorphism is related to the high risk of osteosarcoma development. 30402838 2018
CUI: C0585442
Disease: Osteosarcoma of bone
Osteosarcoma of bone
0.100 GeneticVariation disease BEFREE ERCC1 (C118T (rs11615) and C8092A (rs3212986)) and ERCC2 (A751C (rs171140) and G312A (rs1799793)) polymorphisms were analysed in 44 patients with osteosarcoma, who were treated with cisplatin based neoadjuvant chemotherapy. 29980176 2018
CUI: C0585442
Disease: Osteosarcoma of bone
Osteosarcoma of bone
0.100 GeneticVariation disease BEFREE We found that the T allele of ERCC2-rs1799793 and the A allele of ERCC3-rs4150441, interaction between rs1799793 and rs4150441, and haplotype containing the rs1799793T and rs11615-T alleles were all associated with increased osteosarcoma risk. 28474168 2017
CUI: C0585442
Disease: Osteosarcoma of bone
Osteosarcoma of bone
0.100 GeneticVariation disease BEFREE Genetic polymorphisms in ERCC1 and ERCC2 genes are associated with response to chemotherapy in osteosarcoma patients among Chinese population: a meta-analysis. 28388903 2017
CUI: C0585442
Disease: Osteosarcoma of bone
Osteosarcoma of bone
0.100 GeneticVariation disease BEFREE Our meta-analysis included eleven studies in which four SNPs (ERCC1 rs11615 and rs3212986, ERCC2 rs13181 and rs1799793) reportedly associated with osteosarcoma prognosis were investigated. 28977987 2017
CUI: C0585442
Disease: Osteosarcoma of bone
Osteosarcoma of bone
0.100 GeneticVariation disease BEFREE Future studies with larger sample sizes may contribute in elucidating the impact of ERCC2 and ERCC3 gene polymorphisms on osteosarcoma risks. 27051024 2016
CUI: C0585442
Disease: Osteosarcoma of bone
Osteosarcoma of bone
0.100 GeneticVariation disease BEFREE Association between ERCC1 and ERCC2 gene polymorphisms and chemotherapy response and overall survival in osteosarcoma. 26345951 2015
CUI: C0585442
Disease: Osteosarcoma of bone
Osteosarcoma of bone
0.100 GeneticVariation disease BEFREE In conclusion, our results suggest that ERCC1 rs11615 and ERCC2 rs1799793 may be useful genetic prognostic markers for osteosarcoma in a Chinese population. 26436406 2015
CUI: C0585442
Disease: Osteosarcoma of bone
Osteosarcoma of bone
0.100 GeneticVariation disease BEFREE In conclusion, our study found that the ERCC2 Asn312Asp gene polymorphism likely plays an important role in influencing the chemotherapy response and overall survival of patients with osteosarcoma. 26505449 2015
CUI: C0585442
Disease: Osteosarcoma of bone
Osteosarcoma of bone
0.100 GeneticVariation disease BEFREE Through quantitative analysis, the meta-analysis showed that ERCC2 Lys751Gln (ORGG vs. AA = 0.40 (95%CI = 0.1-0.86), P heterogeneity = 0.502; I (2) = 0 %) and ERCC5 His46His (ORCC vs. TT = 0.37 (95%CI = 0.15-0.93), P heterogeneity = 0.569; I (2) = 0 %) polymorphisms might influence the prognosis of patients with osteosarcoma [1]. 25824708 2015
CUI: C0585442
Disease: Osteosarcoma of bone
Osteosarcoma of bone
0.100 GeneticVariation disease BEFREE Investigation of ERCC1 and ERCC2 gene polymorphisms and response to chemotherapy and overall survival in osteosarcoma. 26400354 2015
CUI: C0585442
Disease: Osteosarcoma of bone
Osteosarcoma of bone
0.100 GeneticVariation disease BEFREE In summary, the ERCC2 Lys751Gln and ERCC5 His46His polymorphisms might influence osteosarcoma prognosis. 25023406 2014
CUI: C0585442
Disease: Osteosarcoma of bone
Osteosarcoma of bone
0.100 GeneticVariation disease BEFREE We first report associations of four SNPs, ERCC1 Asn118Asn, ERCC1 Gln504Lys, ERCC2 Asp312Asn and ERCC2 Lys751Gln, with risk of death from osteosarcoma in a Chinese population, indicating ERCC1 118T/T and ERCC2 A/A may be used as surrogate markers for clinical outcome of osteosarcoma treatment with cisplatin. 23098477 2012
CUI: C0585442
Disease: Osteosarcoma of bone
Osteosarcoma of bone
0.100 GeneticVariation disease BEFREE This study suggests that XPD rs1799793 could be a marker of osteosarcoma associated with features conferring either a better prognosis or a better outcome after platinum therapy, or both. 21826087 2012
CUI: C0585442
Disease: Osteosarcoma of bone
Osteosarcoma of bone
0.100 GeneticVariation disease BEFREE Our study indicated that GSTP1 and ERCC2 Lys751Gln polymorphisms might be candidate pharmacogenomic factors to be explored in the future to identify osteosarcoma patients who might benefit from chemotherapy. 23317281 2012
CUI: C0585442
Disease: Osteosarcoma of bone
Osteosarcoma of bone
0.100 GeneticVariation disease BEFREE Common variations in ERCC2 are associated with response to cisplatin chemotherapy and clinical outcome in osteosarcoma patients. 19434073 2009