Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1527249
Disease: Colorectal Cancer
Colorectal Cancer
0.400 GeneticVariation disease BEFREE Association of ERCC1 and ERCC2 polymorphisms with colorectal cancer risk in a Chinese population. 24531312 2015
CUI: C1527249
Disease: Colorectal Cancer
Colorectal Cancer
0.400 GeneticVariation disease BEFREE The XPD and XRCC1 allelic variants may be prognostic markers for CRC patients receiving 5-FU based chemotherapy. 23894404 2014
CUI: C1527249
Disease: Colorectal Cancer
Colorectal Cancer
0.400 Biomarker disease BEFREE First-line cetuximab plus capecitabine in elderly patients with advanced colorectal cancer: clinical outcome and subgroup analysis according to KRAS status from a Spanish TTD Group Study. 22363067 2012
CUI: C1527249
Disease: Colorectal Cancer
Colorectal Cancer
0.400 GeneticVariation disease BEFREE ERCC1 and ERCC2 polymorphisms predict clinical outcomes of oxaliplatin-based chemotherapies in gastric and colorectal cancer: a systemic review and meta-analysis. 21278243 2011
CUI: C1527249
Disease: Colorectal Cancer
Colorectal Cancer
0.400 Biomarker disease BEFREE Polymorphisms in DNA repair genes XRCC1, XRCC3 and XPD, and colorectal cancer risk: a case-control study in an Indian population. 20229274 2010
CUI: C1527249
Disease: Colorectal Cancer
Colorectal Cancer
0.400 GeneticVariation disease BEFREE Intake of red meat heavily brown on the outside or inside increased CRC risk only among subjects who carried the XPD codon 751 Lys/Lys genotype (case-only interaction P = 0.006 and P = 0.001, respectively, for doneness outside or inside) or the XPD codon 312 Asp/Asp genotype (case-only interaction P = 0.090 and P < 0.001, respectively). 19029193 2009
CUI: C1527249
Disease: Colorectal Cancer
Colorectal Cancer
0.400 Biomarker disease CTD_human Six gene polymorphisms functional in drug-metabolism - GSTP1 Ile105Val, ABCB1 Ile1145Ile, MTHFR Ala222Val, TYMS double (2R) or triple (3R) tandem repeat - and DNA-repair genes - ERCC2 Lys751Gln and XRCC1 Arg399Gln - were assessed in 201 CRC patients using a polymerase chain reaction-restriction fragment-length polymorphism (PCR-RFLP) technique and DNA sequencing. 18267032 2008
CUI: C1527249
Disease: Colorectal Cancer
Colorectal Cancer
0.400 Biomarker disease CTD_human We suggest that ERCC2 2251A>C alleles may be genetic predictors of early CRC relapse. 18267032 2008
CUI: C1527249
Disease: Colorectal Cancer
Colorectal Cancer
0.400 GeneticVariation disease BEFREE We suggest that ERCC2 2251A>C alleles may be genetic predictors of early CRC relapse. 18267032 2008
CUI: C1527249
Disease: Colorectal Cancer
Colorectal Cancer
0.400 GeneticVariation disease BEFREE We found that men featuring the CYP1A1*2C G/G genotype, the GSTT1 null genotype and XPD 751 with the Gln allele were associated with an elevated risk of colorectal cancer than were men who did not exhibit such genetic features. 17191090 2007
CUI: C1527249
Disease: Colorectal Cancer
Colorectal Cancer
0.400 GeneticVariation disease BEFREE XPA A23G, XPC Lys939Gln, XPD Lys751Gln and XPD Asp312Asn polymorphisms, interactions with smoking, alcohol and dietary factors, and risk of colorectal cancer. 17363013 2007
CUI: C1527249
Disease: Colorectal Cancer
Colorectal Cancer
0.400 GeneticVariation disease BEFREE This hospital-based case-control study examined whether polymorphic DNA repair genes: XRCC1 Arg399Gln, XRCC3 Thr241Met and XPD Lys751Gln, play a role in the susceptibility to colorectal cancer. 15914278 2005
CUI: C1527249
Disease: Colorectal Cancer
Colorectal Cancer
0.400 GeneticVariation disease BEFREE Polymorphisms of the XRCC1, XRCC3, & XPD genes, and colorectal cancer risk: a case-control study in Taiwan. 15679883 2005
CUI: C1527249
Disease: Colorectal Cancer
Colorectal Cancer
0.400 GeneticVariation disease BEFREE The genomic polymorphisms XPD-751, ERCC1-118, GSTP1-105, and TS-3'UTR may be useful in predicting overall survival and time to progression of colorectal cancer in patients who receive 5-FU/oxaliplatin chemotherapy. 15213713 2004