AKT1, AKT serine/threonine kinase 1, 207

N. diseases: 1250; N. variants: 33
Disease: Epilepsy ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0014544
Disease: Epilepsy
Epilepsy 		0.360 Biomarker disease BEFREE The role of PI3K/AKT/mTOR signalling pathway has been widely deciphered in pathogenesis of epilepsy. 31563029 2019
CUI: C0014544
Disease: Epilepsy
Epilepsy 		0.360 Biomarker disease BEFREE These results suggest that geniposide attenuates epilepsy in mice through the PI3K/Akt/GSK-3β signaling pathway. 29399113 2018
CUI: C0014544
Disease: Epilepsy
Epilepsy 		0.360 Biomarker disease BEFREE Decreased phospho-AKT and phospho-GSK3β in epilepsy tissue suggested involvement of this pathway in MTLE. 27838154 2017
CUI: C0014544
Disease: Epilepsy
Epilepsy 		0.360 Biomarker disease BEFREE AKT and mTOR-related signals have been recently implicated in the pathogenic processes of epilepsy and FCD. 26961412 2016
CUI: C0014544
Disease: Epilepsy
Epilepsy 		0.360 GeneticVariation disease BEFREE In contrast, expression patterns of the T308 and S473 phosphorylated forms of AKT and in vitro AKT kinase activities discriminated between mutation-positive dysplasia cortex, mutation-negative dysplasia cortex, and non-dysplasia epilepsy cortex. 25722288 2015
CUI: C0014544
Disease: Epilepsy
Epilepsy 		0.360 Biomarker disease BEFREE PI3K-AKT pathway polymerase chain reaction (PCR) array analysis of epilepsy induced by type II focal cortical dysplasia. 26345935 2015
CUI: C0014544
Disease: Epilepsy
Epilepsy 		0.360 Therapeutic disease CTD_human Akt pathway activation and increased neuropeptide Y mRNA expression in the rat hippocampus: implications for seizure blockade. 20064661 2010