|
Osteosarcoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
We recently demonstrated that heat shock protein 90 (HSP90) is involved in the regulation of runt-related transcription factor 2 via the AKT/GSK-3β/β-catenin signaling pathway in OS.
|
31595984 |
2020 |
|
Osteosarcoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
PTEN loss activates a functional AKT/CXCR4 signaling axis to potentiate tumor growth and lung metastasis in human osteosarcoma cells.
|
31571016 |
2020 |
|
Osteosarcoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
MAT1 facilitates the lung metastasis of osteosarcoma through upregulation of AKT1 expression.
|
31421084 |
2019 |
|
Osteosarcoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Expression levels of miR-206 were significantly decreased in OS tissue specimens, compared to adjacent counterparts, and were inversely correlated with expression of PAX3 and MET mRNA. miR-206 directly interacted with PAX3 and MET mRNA in OS cells. miR-206 overexpression significantly reduced PAX3 and MET gene expression in OS cells <i>in vitro</i>, resulting in significant decreases in Akt1 and Erk1/2 activation, cell proliferation, and metastasis, as well as increases in cell apoptosis, while miR-206 knockdown showed the opposite effects.
|
30666838 |
2019 |
|
Osteosarcoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
The PPI network revealed eight hub genes: Ubiquitin‑60S ribosomal protein L40, Ras‑related C3 botulinum toxin substrate, mitogen‑activated protein kinase 1, epidermal growth factor receptor, cystic fibrosis transmembrane conductance regulator, PI3K regulatory subunit 1, AKT1, and actin‑related protein 2/3 complex subunit 1A, which may be the key target genes of miR‑542‑3p in OS.
|
30569116 |
2019 |
|
Osteosarcoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
K-Ras<sup>G12V/Y40C</sup>-PI3K/AKT pathway regulates H1.4<sup>S35ph</sup> through PKA to promote the occurrence and development of osteosarcoma cancer.
|
31126199 |
2019 |
|
Osteosarcoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Finally, the biological function of protein kinase B (AKT) in OS progression mediated by microRNA-183-5p was detected.
|
31646550 |
2019 |
|
Osteosarcoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Pathway analysis demonstrated that the ERK and AKT pathways mediate the regulation of OS progression and chemosensitivity by NSD2.
|
30683853 |
2019 |
|
Osteosarcoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Moreover, <i>UCA1</i> increases CREB1 expression by functioning as a ceRNA against miR-582, thus promoting the EMT process via CREB1-mediated PI3K/AKT/mTOR pathway and finally leading to osteosarcoma metastasis.
|
31011522 |
2019 |
|
Osteosarcoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
MiR-191-5p was found to promote epithelial-mesenchymal transition (EMT) and PI3K/AKT pathway, thus promoting the development of OS.
|
31114985 |
2019 |
|
Osteosarcoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
In sum, we suggest that regorafenib has potential to suppress osteosarcoma progression via inactivation of AKT and ERK mediated signaling pathway.
|
31238539 |
2019 |
|
Osteosarcoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
LncRNA FER1L4 induces apoptosis and suppresses EMT and the activation of PI3K/AKT pathway in osteosarcoma cells via inhibiting miR-18a-5p to promote SOCS5.
|
31473323 |
2019 |
|
Osteosarcoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
We found that hBMSC-MVs promoted U2OS cell proliferation and migration under hypoxia in vitro, and that was partially associated with the PI3K/AKT and HIF-1α pathways.
|
30506278 |
2019 |
|
Osteosarcoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
In conclusion, the study indicated that FER1L4 acted as a tumor suppressor in osteosarcoma via activating PI3K/AKT pathway may be a new prognostic biomarker and potential therapeutic target for osteosarcoma intervention.
|
31000382 |
2019 |
|
Osteosarcoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Therefore, this study aims to investigate the molecular mechanism of SIX1 and PTEN/PI3K/AKT on osteosarcoma progression.
|
29807230 |
2018 |
|
Osteosarcoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
MiR-524 induces the proliferation of osteosarcoma cells through activation of the PI3K/AKT pathway via inhibition of the target gene PTEN, which provides a theoretical basis for selecting a new therapeutic target for osteosarcoma.
|
30123092 |
2018 |
|
Osteosarcoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
miR-149-5p inhibits cell growth by regulating TWEAK/Fn14/PI3K/AKT pathway and predicts favorable survival in human osteosarcoma.
|
30014744 |
2018 |
|
Osteosarcoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Here, in our study, we found that PI3K/AKT/mTOR pathway was involved in osteosarcoma progression.
|
29904919 |
2018 |
|
Osteosarcoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Global gene expression profiling of CEP55-silenced MNNG/HOS cells showed that the AKT pathway might be involved in the regulation of OS cell activity.
|
29579156 |
2018 |
|
Osteosarcoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
MicroRNA-124 suppresses growth and aggressiveness of osteosarcoma and inhibits TGF-β-mediated AKT/GSK-3β/SNAIL-1 signaling.
|
29488603 |
2018 |
|
Osteosarcoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
PP2A was a direct target of miR-21, which participated in the effects of ASBEL and miR-21 on the activation of phosphatidylinositol 3-kinase/protein kinase 3/glycogen synthase kinase-3β (PI3K/AKT/GSK3β) and mitogen-activated protein kinase/extracellular regulated protein kinase (MEK/ERK) signaling pathways as well as the enhancement of osteosarcoma cell proliferation, migration, and invasion.
|
29323740 |
2018 |
|
Osteosarcoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Lowly expressed microRNA-520d-3p was observed in osteosarcoma; overexpression of microRNA-520d-3p can target Akt1 thus inhibiting proliferation of osteosarcoma cells.
|
29762834 |
2018 |
|
Osteosarcoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Overexpression of hsa_circ_0007534 predicts unfavorable prognosis for osteosarcoma and regulates cell growth and apoptosis by affecting AKT/GSK-3β signaling pathway.
|
30142548 |
2018 |
|
Osteosarcoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Western blot analysis was performed to detect the expression levels of phosphatidylinositol 3‑kinase (PI3K), phospho (p)‑PI3K, RAC‑alpha serine/threonine‑protein kinase (AKT), p‑AKT and NF‑κB inhibitor α (IκBα) in osteosarcoma cells transfected with H19 siRNA.
|
29568924 |
2018 |
|
Osteosarcoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
In addition, the AKT pathway activation promoted TUG1 expression by upregulating the expression of FOXM1, forming a positive feedback loop in osteosarcoma.
|
30099814 |
2018 |