AKT1, AKT serine/threonine kinase 1, 207

N. diseases: 1250; N. variants: 33
Disease: Ovarian Carcinoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma 		0.330 Biomarker disease BEFREE Inhibiting the PI3K/AKT pathway may be a useful treatment for ovarian carcinoma. 25216292 2014
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma 		0.330 Biomarker disease BEFREE Although many tumors presented a single lesion (28/93, of which 23 overexpressed PIK3CA, 1 overexpressed AKT and 4 had lost PTEN), many OC (35/93) presented multiple alterations within the PI3K pathway. 23408974 2013
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma 		0.330 Biomarker disease BEFREE Our results underline the prognostic significance of PIK3CA in ovarian carcinoma and argue against a simple linear model of PIK3CA gain/amplification followed by PI3K activation and consecutive AKT phosphorylation in ovarian carcinoma. 17377809 2007
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma 		0.330 CausalMutation disease CGI