Schizophrenia
|
0.900 |
Biomarker
|
disease |
BEFREE |
We propose that through convergence on AKT/mTOR signaling, these genes are critical factors directing both placentation and neurodevelopment, influencing risk for SCZ through dysregulation of placental function, metabolism and early brain development.
|
31522868 |
2019 |
Schizophrenia
|
0.900 |
Biomarker
|
disease |
BEFREE |
This association is likely to reflect modulation of dopamine signaling by Akt1 kinase since striatal dopamine hyperstimulation is associated with psychosis and schizophrenia.
|
28416594 |
2017 |
Schizophrenia
|
0.900 |
Biomarker
|
disease |
BEFREE |
With this premise, this study examined in HeLa and other cell lines the effects of different APDs on the activation of ERK1/2 (Extracellular signal-regulated kinases) and AKT (Protein Kinase B) kinases, which may be affected in schizophrenia and bipolar disorder.
|
28283227 |
2017 |
Schizophrenia
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
The intronic single-nucleotide polymorphism rs707284 in ERBB4 links to PI3K-AKT suppression in SZ.
|
28384043 |
2017 |
Schizophrenia
|
0.900 |
Biomarker
|
disease |
BEFREE |
PKBγ/AKT3 loss-of-function causes learning and memory deficits and deregulation of AKT/mTORC2 signaling: Relevance for schizophrenia.
|
28467426 |
2017 |
Schizophrenia
|
0.900 |
Biomarker
|
disease |
BEFREE |
These results implicate dopaminergic dysregulation as a mechanism underlying the increased rate of schizophrenia seen in DISC1 variant carriers, and provide insights into how DISC1, and potentially DISC1-interacting proteins such as AKT and GSK-3, could be used as novel therapeutic targets for schizophrenia.
|
28140405 |
2017 |
Schizophrenia
|
0.900 |
AlteredExpression
|
disease |
BEFREE |
Decreased VEGFR2 expression and increased phosphorylated Akt1 in the prefrontal cortex of individuals with schizophrenia.
|
27484635 |
2016 |
Schizophrenia
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
The current study examined the interactive effects of TCF4 and AKT1 variants with gender, family history of psychiatric disorders and ethnicity on the AAO of schizophrenia.
|
27305091 |
2016 |
Schizophrenia
|
0.900 |
Biomarker
|
disease |
BEFREE |
Many susceptible genes have been identified in schizophrenia such as catechol-O-methyltransferase (COMT) and serine/threonine kinase (AKT1).
|
25801838 |
2015 |
Schizophrenia
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
This analysis identified 624 genes with altered expression (208 up-regulated, 416 down-regulated) prior to antipsychotic treatment (p < 0.05) including schizophrenia-associated genes AKT1, DISC1 and DGCR6.
|
23442539 |
2013 |
Schizophrenia
|
0.900 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
Germline PIK3CA and AKT1 mutations in Cowden and Cowden-like syndromes.
|
23246288 |
2013 |
Schizophrenia
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
Our results suggest that a genetic variant of AKT1 might be associated with attentional deficits and brain morphological vulnerability in patients with schizophrenia.
|
22150081 |
2013 |
Schizophrenia
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
No association between AKT1 gene variants and schizophrenia: a Malaysian case-control study and meta-analysis.
|
23747160 |
2013 |
Schizophrenia
|
0.900 |
Biomarker
|
disease |
BEFREE |
Taken together, these results implicate the Akt1 isoform in regulating hippocampal neuroplasticity and cognition and in contributing to the etiology of schizophrenia.
|
21049487 |
2012 |
Schizophrenia
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
In this study, our aim was to determine whether AKT1 gene variants are associated with particular phenotypes for schizophrenia (SCZ) and bipolar disorder (BPD).
|
22277669 |
2012 |
Schizophrenia
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
In the context of anti-psychotic drugs, the DRD2 and AKT1 polymorphisms altered dose-response effects of anti-psychotic drugs on cognition in schizophrenia (n = 111).
|
22525159 |
2012 |
Schizophrenia
|
0.900 |
Biomarker
|
disease |
BEFREE |
Patients with schizophrenia displayed decreased AKT but normal ERK ratio compared with controls.
|
22209534 |
2012 |
Schizophrenia
|
0.900 |
Biomarker
|
disease |
BEFREE |
Genetic linkage and association studies have identified Akt-1 as a candidate susceptibility gene related for schizophrenia.
|
22771711 |
2012 |
Schizophrenia
|
0.900 |
Biomarker
|
disease |
BEFREE |
Our findings suggest that AKT1 affects risk for schizophrenia and accompanying cognitive deficits, at least in part through specific genetic interactions related to brain neuroplasticity and development, and that these AKT1 effects may be pharmacologically modulated in patients.
|
21788944 |
2012 |
Schizophrenia
|
0.900 |
AlteredExpression
|
disease |
BEFREE |
The purpose of this review is to detail how putative schizophrenia risk genes (DISC-1, neuregulin/ErbB4, dysbindin, Akt1, BDNF, and the NMDA receptor) are involved in regulating neuroplasticity and how alterations in their expression may contribute to the disconnectivity observed in schizophrenia.
|
20951727 |
2011 |
Schizophrenia
|
0.900 |
Biomarker
|
disease |
BEFREE |
We measured AKT1 and GSK-3β proteins and phosphorylation in human peripheral blood mononuclear cells, functional MRI cingulate response during attentional control, behavioral accuracy during sustained attention, and response to 8 wk of treatment with olanzapine in a total of 190 healthy subjects and 66 patients with schizophrenia.
|
21187413 |
2011 |
Schizophrenia
|
0.900 |
Biomarker
|
disease |
CTD_human |
We measured AKT1 and GSK-3β proteins and phosphorylation in human peripheral blood mononuclear cells, functional MRI cingulate response during attentional control, behavioral accuracy during sustained attention, and response to 8 wk of treatment with olanzapine in a total of 190 healthy subjects and 66 patients with schizophrenia.
|
21187413 |
2011 |
Schizophrenia
|
0.900 |
Biomarker
|
disease |
BEFREE |
Several publications support the implication of AKT1 in disorders of the dopaminergic system including bipolar disease and schizophrenia.
|
21741444 |
2011 |
Schizophrenia
|
0.900 |
Biomarker
|
disease |
BEFREE |
Taken together, our results do not support the hypothesis that AKT1 is a susceptibility gene for schizophrenia.
|
19931325 |
2010 |
Schizophrenia
|
0.900 |
Biomarker
|
disease |
BEFREE |
In conclusion, our findings, by showing the involvement of the AKT1 gene in both schizophrenia and bipolar disorder, support the role of AKT1 in the genetics of both disorders and add support to the view that there is some genetic overlap between them.
|
20214684 |
2010 |