Glioblastoma Multiforme
0.320
Biomarker
disease
BEFREE
Dual IRE1 RNase functions dictate glioblastoma development.
29311133
2018
Glioblastoma Multiforme
0.320
AlteredExpression
disease
BEFREE
The presence of IRE1α , but not its RNase activity, is therefore required for glioblastoma neovascularization, whereas invasion results only from RNase inhibition.
26325176
2015
Glioblastoma Multiforme
0.320
GeneticVariation
disease
UNIPROT
Adenocarcinoma of lung (disorder)
0.310
AlteredExpression
disease
BEFREE
High expression of IRE1 in lung adenocarcinoma is associated with a lower rate of recurrence.
28334878
2017
Adenocarcinoma of lung (disorder)
0.310
GeneticVariation
disease
UNIPROT
Hepatitis, Toxic
0.300
Biomarker
disease
CTD_human
Inositol-Requiring Enzyme 1 Alpha Endoribonuclease Specific Inhibitor STF-083010 Alleviates Carbon Tetrachloride Induced Liver Injury and Liver Fibrosis in Mice.
30538632
2018
Liver Cirrhosis, Experimental
0.300
Biomarker
disease
CTD_human
Inositol-Requiring Enzyme 1 Alpha Endoribonuclease Specific Inhibitor STF-083010 Alleviates Carbon Tetrachloride Induced Liver Injury and Liver Fibrosis in Mice.
30538632
2018
Drug-Induced Liver Disease
0.300
Biomarker
phenotype
CTD_human
Inositol-Requiring Enzyme 1 Alpha Endoribonuclease Specific Inhibitor STF-083010 Alleviates Carbon Tetrachloride Induced Liver Injury and Liver Fibrosis in Mice.
30538632
2018
Hepatitis, Drug-Induced
0.300
Biomarker
disease
CTD_human
Inositol-Requiring Enzyme 1 Alpha Endoribonuclease Specific Inhibitor STF-083010 Alleviates Carbon Tetrachloride Induced Liver Injury and Liver Fibrosis in Mice.
30538632
2018
Drug-Induced Acute Liver Injury
0.300
Biomarker
disease
CTD_human
Inositol-Requiring Enzyme 1 Alpha Endoribonuclease Specific Inhibitor STF-083010 Alleviates Carbon Tetrachloride Induced Liver Injury and Liver Fibrosis in Mice.
30538632
2018
Chemical and Drug Induced Liver Injury
0.300
Biomarker
disease
CTD_human
Inositol-Requiring Enzyme 1 Alpha Endoribonuclease Specific Inhibitor STF-083010 Alleviates Carbon Tetrachloride Induced Liver Injury and Liver Fibrosis in Mice.
30538632
2018
Chemically-Induced Liver Toxicity
0.300
Biomarker
disease
CTD_human
Inositol-Requiring Enzyme 1 Alpha Endoribonuclease Specific Inhibitor STF-083010 Alleviates Carbon Tetrachloride Induced Liver Injury and Liver Fibrosis in Mice.
30538632
2018
Epilepsy
0.300
Biomarker
disease
CTD_human
[Effects of edaravone on IRE1 mRNA expression and neuronal apoptosis in the hippocampus of rats with status convulsivus].
19558813
2009
Epilepsy, Cryptogenic
0.300
Biomarker
disease
CTD_human
[Effects of edaravone on IRE1 mRNA expression and neuronal apoptosis in the hippocampus of rats with status convulsivus].
19558813
2009
×
CUI:
C0236018
Disease:
Aura
Aura
0.300
Biomarker
phenotype
CTD_human
[Effects of edaravone on IRE1 mRNA expression and neuronal apoptosis in the hippocampus of rats with status convulsivus].
19558813
2009
Awakening Epilepsy
0.300
Biomarker
disease
CTD_human
[Effects of edaravone on IRE1 mRNA expression and neuronal apoptosis in the hippocampus of rats with status convulsivus].
19558813
2009
Gastric Adenocarcinoma
0.300
GeneticVariation
disease
UNIPROT
Conventional (Clear Cell) Renal Cell Carcinoma
0.300
GeneticVariation
disease
UNIPROT
Ovarian Serous Adenocarcinoma
0.300
GeneticVariation
disease
UNIPROT
Crohn Disease
0.110
Biomarker
disease
BEFREE
In this study, we report that mice with Atg16l1 deletion in intestinal epithelial cells (IECs) spontaneously develop transmural ileitis phenocopying ileal CD in an age-dependent manner, driven by the endoplasmic reticulum (ER) stress sensor IRE1α .
28082357
2017
Crohn Disease
0.110
GeneticVariation
disease
GWASCAT
Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci.
26974007
2016
Malignant Neoplasms
0.100
Biomarker
group
BEFREE
As the most conserved branch among the three un-folded protein response (UPR) pathways, Inositol-requiring enzyme 1α (IRE1α )-X-box-binding protein 1 (XBP1) signaling has been implicated in cancer development and progression.
31205564
2019
Malignant Neoplasms
0.100
Biomarker
group
BEFREE
Finally, as more is learned about the context-dependent role of IRE1α in cancer development, specific small molecule inhibitors and activators of IRE1α could play an important role in counteracting the protective shield provided by ER stress signaling in cancer cells.
31041814
2019
Malignant Neoplasms
0.100
Biomarker
group
BEFREE
Though IRE1α is implicated in development of cancer , the role and underlying mechanism remain unclear.
31326465
2019
Neoplasms
0.100
AlteredExpression
group
BEFREE
There were no significant differences in IRE1α mRNA and protein expression between the two groups and XBP1s mRNA levels were increased in the tumor compared with the control group.
30936991
2019