|
Fibroid Tumor
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
In the present study, by evaluating G protein-coupled estrogen receptor (GPER), ERα36, and phospho-epidermal growth factor receptor (EGFR) expression in human tissues, we found that GPER, ERα36 and phospho-EGFR were all highly expressed in fibroids compared to patient-matched myometrial tissues.
|
31468104 |
2019 |
|
Fibroid Tumor
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The purpose of this study was to analyze the effect of ERα-351 XbaI A/G, ERα-397 PvuII T/C, and progesterone receptor (PGR) PROGINS polymorphisms on the development of leiomyomas.
|
30390345 |
2019 |
|
Fibroid Tumor
|
0.400 |
Biomarker
|
disease |
BEFREE |
It highlights the difficulty in classifying some gastrointestinal SMNs as either LMs or LMSs and the importance of ER status in SMNs.
|
30431607 |
2018 |
|
Fibroid Tumor
|
0.400 |
Biomarker
|
disease |
BEFREE |
Transthoracic needle biopsy was performed and the resected lesion consisted of benign spindle cells was positive for estrogen receptor (ER) and progesterone receptor (PR) and was diffuse positive for actin and desmin by immunohistochemical (IHC) staining, suggesting leiomyoma.
|
28203428 |
2017 |
|
Fibroid Tumor
|
0.400 |
Biomarker
|
disease |
BEFREE |
ER-alpha, ER-beta, and PR proteins were also higher in leiomyomas and the level of these proteins negatively correlated with the level of 14-3-3 gamma protein.
|
27100507 |
2016 |
|
Fibroid Tumor
|
0.400 |
Biomarker
|
disease |
BEFREE |
Estrogen stimulates cell proliferation through binding to the estrogen receptor (ER), of which both subtypes α and β are present in leiomyomas.
|
26529545 |
2016 |
|
Fibroid Tumor
|
0.400 |
Biomarker
|
disease |
BEFREE |
One extrauterine, retroperitoneal estrogen receptor-positive leiomyoma was also FH deficient.
|
27454940 |
2016 |
|
Fibroid Tumor
|
0.400 |
Biomarker
|
disease |
BEFREE |
A specific category of leiomyomas are estrogen-receptor positive ones in women.
|
24384850 |
2014 |
|
Fibroid Tumor
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The protein expression of ERα, ERβ and aromatase was similar in leiomyoma and normal myometrium (p = 0.239, p = 0.695 and p = 0.203, respectively).
|
22377971 |
2012 |
|
Fibroid Tumor
|
0.400 |
Biomarker
|
disease |
BEFREE |
The spearman's rho (ρ) was .53 (P = .008) between HDAC6 and ERα in normal myometrium and, more significantly, the spearman rho was .80 (P < .001) between HDAC6 and ERα in leiomyoma.
|
21421902 |
2011 |
|
Fibroid Tumor
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
A T/C SNP in intron 1 and exon 2 boundary of estrogen receptor (ER) alpha gene recognized by PvuII enzyme has been associated with several female pathologies like breast cancer, osteoporosis, endometriosis and fibroids in various ethnic groups.
|
19729795 |
2009 |
|
Fibroid Tumor
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Estrogen receptor subtype alpha mRNA levels were significantly, and 1.8- to 2.6-fold, higher in leiomyoma compared with adjacent myometrium in all groups, whereas leiomyoma estrogen receptor subtype beta mRNA levels were significantly elevated only in Japanese women.
|
19240151 |
2009 |
|
Fibroid Tumor
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Further analysis of the DNA methylation status by bisulfite restriction mapping among 11 paired samples of myometrium and leiomyoma indicated that CpG sites in the distal region of ER-alpha promoter are hypomethylated in leiomyomas of nine patients.
|
18701604 |
2008 |
|
Fibroid Tumor
|
0.400 |
AlteredExpression
|
disease |
LHGDN |
A prospective study focusing on leiomyoma was conducted to investigate the expression of estrogen receptor-alpha (ER alpha), estrogen receptor-beta (ER beta) and insulin-like growth factor-I (IGF-I) to elucidate their roles in the pathogenesis of leiomyoma.
|
19012097 |
2008 |
|
Fibroid Tumor
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The level of messenger RNA expression of estrogen receptor alpha and beta and the level of estrogen receptor as a whole are increased on average to a similar extent in leiomyomas compared with normal myometrium.
|
18166184 |
2008 |
|
Fibroid Tumor
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
A prospective study focusing on leiomyoma was conducted to investigate the expression of estrogen receptor-alpha (ER alpha), estrogen receptor-beta (ER beta) and insulin-like growth factor-I (IGF-I) to elucidate their roles in the pathogenesis of leiomyoma.
|
19012097 |
2008 |
|
Fibroid Tumor
|
0.400 |
AlteredExpression
|
disease |
LHGDN |
A low concentration of genistein induces estrogen receptor-alpha and insulin-like growth factor-I receptor interactions and proliferation in uterine leiomyoma cells.
|
18492705 |
2008 |
|
Fibroid Tumor
|
0.400 |
Biomarker
|
disease |
CTD_human |
Further analysis of the DNA methylation status by bisulfite restriction mapping among 11 paired samples of myometrium and leiomyoma indicated that CpG sites in the distal region of ER-alpha promoter are hypomethylated in leiomyomas of nine patients.
|
18701604 |
2008 |
|
Fibroid Tumor
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We aimed to elucidate the association of estrogen receptor alpha (ERalpha)-351 A>G (XbaI) and -397 T>C (PvuII) gene polymorphisms with endometriosis and leiomyoma.
|
17121748 |
2007 |
|
Fibroid Tumor
|
0.400 |
AlteredExpression
|
disease |
LHGDN |
Premenopausal leiomyomas are known to express higher levels of estrogen receptor-alpha (ERalpha), estrogen receptor-beta (ERbeta) and progesterone receptor (PGR) than control myometrium, whereas postmenopausal leiomyomas have not been so well characterized molecularly.
|
17646097 |
2007 |
|
Fibroid Tumor
|
0.400 |
GeneticVariation
|
disease |
LHGDN |
We aimed to elucidate the association of estrogen receptor alpha (ERalpha)-351 A>G (XbaI) and -397 T>C (PvuII) gene polymorphisms with endometriosis and leiomyoma.
|
17121748 |
2007 |
|
Fibroid Tumor
|
0.400 |
Biomarker
|
disease |
BEFREE |
Furthermore, our findings provided little support for the association of these SNPs on ESR1 with leiomyoma.
|
16935316 |
2006 |
|
Fibroid Tumor
|
0.400 |
Biomarker
|
disease |
BEFREE |
Our in vivo data in a mouse model demonstrate the ability of an adenovirus-expressing dominant-negative ER to arrest leiomyoma growth.
|
16603566 |
2006 |
|
Fibroid Tumor
|
0.400 |
Biomarker
|
disease |
LHGDN |
Estrogen and progesterone receptors expression in gastrointestinal stromal tumors and intramural gastrointestinal leiomyomas.
|
17992477 |
2006 |
|
Fibroid Tumor
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
This study was undertaken to investigate a potential therapy for leiomyoma; we used a mutated dominant-negative estrogen receptor gene delivered via an adenoviral vector (Ad-ER-DN).
|
15547533 |
2004 |