ESR1, estrogen receptor 1, 2099

N. diseases: 1101; N. variants: 185
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.400 Biomarker disease BEFREE E6-Associated Protein Dependent Estrogen Receptor Regulation of Protein Kinase A Regulatory Subunit R2A Expression in Neuroblastoma. 28214999 2018
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.400 PosttranslationalModification disease BEFREE The purpose of our study was to investigate the effects of estrogen receptor (ER)-α36 gene silencing on tau protein phosphorylation, cell proliferation, and cell apoptosis in human neuroblastoma SH-SY5Y cells. 29932870 2018
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.400 Biomarker disease BEFREE Further examination revealed that infection with ERA-N273/394-G333 induces IFN-β and CXCL10 mRNA expressions more strongly than ERA-G333 infection in a neuroblastoma cell line. 28882441 2017
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.400 Biomarker disease CTD_human Transcription factor activity of estrogen receptor α activation upon nonylphenol or bisphenol A treatment enhances the in vitro proliferation, invasion, and migration of neuroblastoma cells. 27366082 2016
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.400 Biomarker disease BEFREE Estrogen receptor α regulates non-canonical autophagy that provides stress resistance to neuroblastoma and breast cancer cells and involves BAG3 function. 26158518 2015
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.400 AlteredExpression disease BEFREE Estrogen receptor-mediated transcription involves the activation of multiple kinase pathways in neuroblastoma cells. 24121066 2014
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.400 Biomarker disease BEFREE Differential regulation of apoptosis-associated genes by estrogen receptor alpha in human neuroblastoma cells. 23271418 2013
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.400 AlteredExpression disease BEFREE MYCN-regulated microRNAs repress estrogen receptor-alpha (ESR1) expression and neuronal differentiation in human neuroblastoma. 20080637 2010
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.400 Biomarker disease BEFREE Ginsenoside Rg1 protects against 6-OHDA-induced neurotoxicity in neuroblastoma SK-N-SH cells via IGF-I receptor and estrogen receptor pathways. 19476546 2009
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.400 Biomarker disease BEFREE Therefore, we analyzed the binding of [3H]-diprenorphine in human neuroblastoma cells stably transfected with the estrogen receptor cDNA (SK-ER3 cell line). 9892851 1999
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.400 Biomarker disease BEFREE To evaluate the role of estrogen receptor in the differentiation of cells of neural origin, we developed a molecular approach aimed at the identification of estrogen target genes by mRNA differential display PCR (ddPCR) in human neuroblastoma SK-ER3 cells. 9169520 1997
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.400 Biomarker disease BEFREE Neurotransmitters activate the human estrogen receptor in a neuroblastoma cell line. 9328204 1997
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.400 AlteredExpression disease BEFREE The finding that, in neuroblastoma cells, selected signal transduction systems are involved in the insulin-dependent activation of estrogen receptor is of particular interest considering that estrogen receptor might restrict the role played by insulin during the differentiation of neural cells and interfere with its proliferative potential while allowing its regulation of other functions related to cell survival. 8732681 1996
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.400 Biomarker disease BEFREE In order to assess the neuronal-like properties of a human neuroblastoma cell line obtained by stable transfection of the estrogen receptor (SK-ER3) a series of quantitative measurements of the activity of two neurotransmitter-related enzymes: tyrosine hydroxylase (TH) and monamine oxidase (MAO), and of catecholamine concentrations were performed. 7903862 1993
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.400 AlteredExpression disease BEFREE The lack of model systems in which these phenomena could be studied prompted us to develop a neuroblastoma cell line expressing the estrogen receptor. 8475123 1993