Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
The role of progesterone receptor (PR) status on the association between obesity and prognosis of estrogen receptor positive (ER+) breast cancer (BC) remains poorly understood.
|
31403177 |
2020 |
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
Obesity is a risk factor for estrogen receptor-positive (ER+) breast cancer after menopause.
|
30851382 |
2019 |
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
The combination of overweight/obesity and elevated breast density in premenopausal women is associated with a higher risk of ER-negative compared with ER-positive cancer.
|
30944014 |
2019 |
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
Obesity had a negative impact on improvement in the DAS with 28 joints using ESR as an inflammation marker of -0.15 (95% CI: -0.26; -0.04) units for women receiving conventional synthetic DMARDs, -0.22 (95% CI: -0.31; -0.12) units for women receiving TNF inhibitors, -0.22 (95% CI: -0.42; -0.03) units for women receiving tocilizumab and -0.41 (95% CI: -0.74; -0.07) units for men receiving tocilizumab.
|
31745566 |
2019 |
Obesity
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Obesity is associated with an increased risk of breast cancer, including the estrogen receptor (ER)-positive subtype in postmenopausal women.
|
30520976 |
2019 |
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
Loss of ESR1 increases weight gain and obesity in female rats, while reducing the normal growth in males.
|
30974146 |
2019 |
Obesity
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
CNM (1) normalized serum estradiol-17β levels, (2) induced gastric Nrf2 and phase II antioxidant enzymes through extracellular signal-regulated kinase, (ERK)/c-Jun N-terminal kinase (JNK)/p38 mitogen-activated protein kinase (MAPK), (3) reduced glucose synthase kinase 3 beta (GSK3β) and aryl hydrocarbon receptor (AhR) and this was associated with (4) increased estrogen receptor expression, BH<sub>4</sub> (Cofactor of nNOS) biosynthesis enzyme GCH-1 and nNOSα dimerization in WT Obese/T2 diabetic female mice.
|
30831189 |
2019 |
Obesity
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Increased mTORC1 signaling in obesity ensures the strong activation of oncogenic signaling in E2Rα-positive breast cancer cells.
|
30620711 |
2019 |
Obesity
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Aromatase inhibitors are the preferred treatment for certain women with estrogen receptor (ER)-positive breast cancer, but evidence suggests that women with obesity experience aromatase inhibitor resistance at higher rates.
|
31002529 |
2019 |
Obesity
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
The aim of this retrospective study was to explore the possible correlation in the EC microenvironment between master regulators of complex phenomena such as steroid responsiveness through estrogen receptor alpha (ERα) and progesterone receptor (PR), epithelial-to-mesenchymal transition (supported by SLUG transcription factor), hypoxia (with hypoxia inducible factor-1 alpha, HIF-1α), and obesity that has been recognized as a EC risk factor.
|
31220580 |
2019 |
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
We assessed the associations between BMI and gene expression of both breast tumor and adjacent tissue in estrogen receptor-positive (ER+) and estrogen receptor-negative (ER-) diseases to help elucidate the mechanisms linking obesity with breast cancer biology in 519 post-menopausal women from the Nurses' Health Study (NHS) and NHSII.
|
30387004 |
2019 |
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
Free Fatty Acids Rewire Cancer Metabolism in Obesity-Associated Breast Cancer via Estrogen Receptor and mTOR Signaling.
|
30862719 |
2019 |
Obesity
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Disease activity was assessed by DAS28-ESR, and obesity was determined by waist circumference (WC), BMI and dual-energy X-ray absorptiometry (DXA).
|
29947997 |
2018 |
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
In the present study, we explored the effects of a grape seed extract (GSE) enriched in the flavan-3-ols procyanidin dimers on obesity-related cardiovascular and metabolic disorders; with a particular interest in the role/contribution of ERα.
|
29740325 |
2018 |
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
Here, we identified regulatory pathways in estrogen receptor-positive (ER-positive) tumors that were shared between patients with obesity and those with resistance to neoadjuvant aromatase inhibition.
|
30046001 |
2018 |
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
Although it has been well-documented that obesity is associated with decreased risk of premenopausal breast cancer and increased risk of postmenopausal breast cancer, it is unclear whether these associations differ among breast cancer subtypes defined by the tumor protein expression status of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2).
|
29357906 |
2018 |
Obesity
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Our results suggest that polymorphisms of the ESR1 gene do not contribute significantly to the genetic risk for obesity phenotypes in a population of young Caucasian adults.
|
28627236 |
2018 |
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
To investigate the contribution of serum levels of testosterone (TS) and sex hormone binding globulin (SHBG) in association with body mass index (BMI) as a surrogate marker of obesity, to the predictive capability of tumor size (T), lymph node (N) and estrogen receptor (ER) status and proliferative activity (TLI).
|
29474646 |
2018 |
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
N-terminal transactivation function, AF-1, of estrogen receptor alpha controls obesity through enhancement of energy expenditure.
|
30287090 |
2018 |
Obesity
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The data suggest a possibility that dietary <i>S</i>-equol could be an alternative to hormone replacement therapy for the prevention of hyperphagia and obesity with a lower risk of adverse effects induced by ER-α stimulation.
|
29097993 |
2017 |
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
Thus, it is speculated that such ESR1 epigenetic changes may be influenced or shaped by obesity and reproductive history-related factors before and during breast carcinogenesis.
|
28708432 |
2017 |
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
Selective Activation of Estrogen Receptor α Activation Function-1 Is Sufficient to Prevent Obesity, Steatosis, and Insulin Resistance in Mouse.
|
28502695 |
2017 |
Obesity
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The insulin signaling network is influenced by obesity and may interact with the estrogen receptor α (ERα) signaling.
|
29234306 |
2017 |
Obesity
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Obesity reversibly depletes the basal cell population and enhances mammary epithelial cell estrogen receptor alpha expression and progenitor activity.
|
29187227 |
2017 |
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
Adding dichotomous tumor ER or PR status to the panel of standard predictors did not improve both model discrimination and calibration.<b>Conclusions:</b> Obesity may be associated with greater endometrial tumor expression of ER and PR.
|
28052940 |
2017 |