Osteoporosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We aim to investigate the impact of estrogen receptor gene (<i>ESR1</i>) gene polymorphisms on bone mineral density (BMD) in patients with ulcerative colitis (UC) and Crohn's disease (CD), as they may contribute both, to osteoporosis and inflammatory processes.
|
31450614 |
2019 |
Osteoporosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Compound <b>24</b> is a nanomolar potent inhibitor of human 17β-HSD2 (IC<sub>50</sub> of 6.1 nM) and rodent 17β-HSD2 with low in vitro cellular toxicity, devoid of detectable estrogen receptor α affinity, displays high aqueous solubility and in vitro metabolic stability, and has an excellent oral pharmacokinetic profile for testing in a rat osteoporosis model.
|
31343176 |
2019 |
Osteoporosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Association of RMND1/CCDC170-ESR1 single nucleotide polymorphisms with hip fracture and osteoporosis in postmenopausal women.
|
30601066 |
2019 |
Osteoporosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The correlations between osteoporosis and either the BsmI restriction site polymorphism in VDR or the (TA)n repeat polymorphism in ESR1 were analyzed in 73 and 67 genotyped patients, respectively.
|
28161223 |
2019 |
Osteoporosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Raloxifene is an FDA-approved estrogen receptor drug that is used to treat osteoporosis, but it was recently found to also show noteworthy CB2 inverse agonism.
|
31518568 |
2019 |
Osteoporosis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Aberrant expression of estrogen receptor alpha (ER-α) is observed in many pathological complications like breast cancer, endometrial cancer, and in osteoporosis.
|
29777335 |
2018 |
Osteoporosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
The estrogen receptor 1 gene affects bone mineral density and osteoporosis treatment efficiency in Slovak postmenopausal women.
|
30241506 |
2018 |
Osteoporosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The aim of the present meta-analysis is to verify the association between ERα and ERβ gene polymorphisms and osteoporosis susceptibility and BMD in postmenopausal women.
|
29458346 |
2018 |
Osteoporosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Estrogen resistance due to mutations in the estrogen receptor α gene (ESR1) has been described in men and women and is characterized by osteoporosis, delayed bone age and continuous growth in adulthood, and delayed puberty and multiple ovarian cysts in women.
|
30113650 |
2018 |
Osteoporosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The correlation between estrogen receptor gene polymorphism and osteoporosis in Han Chinese women.
|
30556843 |
2018 |
Osteoporosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In multivariable logistic regression models, BMI ≤ 22 kg/m (odds ratio = 3.43, P = .043) and DAS28-ESR > 3.2 (odds ratio = 3.85, P = .032) were independent risk factors for osteoporosis at either site in male patients with RA.Our data demonstrate that male patients with RA had a 2.1 times higher risk for osteoporosis compared with healthy individuals.
|
29901636 |
2018 |
Osteoporosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
For the ER-α gene, no evidence of significant association of PvuII or XbaI polymorphism with OP risk was found.
|
28884379 |
2018 |
Osteoporosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Bazedoxifene, a selective estrogen receptor modulator with proestrogenic effects on bone and lipid metabolism and antiestrogenic effects on the breast and endometrium, is a treatment option for osteoporosis in postmenopausal women.
|
29443456 |
2018 |
Osteoporosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Bazedoxifene (BZA), a chemically distinct selective estrogen receptor modulator, has demonstrated efficacy and long-term safety in phase 3 placebo-controlled studies for prevention and treatment of osteoporosis.
|
30144296 |
2018 |
Osteoporosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Raloxifene, a selective estrogen receptor modulator, has been used extensively for osteoporosis.
|
28238769 |
2017 |
Osteoporosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
In the final model of all-cause mortality increased baseline ESR [hazard ratio (HR) 1.02 per mm/h, 95% CI: 1.01-1.03], calcium supplementation (1.74, 1.07-2.84), and osteoporosis, defined as a T score ≤2.5 SD at any location, (1.58, 1.07-2.32) predicted higher mortality rates, in models adjusted for age, gender, and a propensity score.
|
27522465 |
2017 |
Osteoporosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Evista (Raloxifene·HCl) is known as selective estrogen receptor modulator which has been used for the prevention and treatment of osteoporosis and was approved for reducing the risk of invasive breast cancer.
|
28711499 |
2017 |
Osteoporosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Although several drugs such as bisphosphonates, estrogen replacement treatment, and selective estrogen receptor modulators have been used to treat osteoporosis, all these are not the ideal drugs because of insufficient curative ability and adverse side effects.
|
27119523 |
2017 |
Osteoporosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Nuclear receptors such as the estrogen receptors (ERα and ERβ) modulate the effects of the estrogen hormones and are important targets for design of innovative chemotherapeutic agents for diseases such as breast cancer and osteoporosis.
|
28858267 |
2017 |
Osteoporosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Bioavailable isoflavones with selective estrogen receptor affinity show potential to prevent and treat osteoporosis while minimizing or eliminating carcinogenic side effects.<b>Objective:</b> In this study, we sought to determine the beneficial effects of a bioavailable isoflavone and probiotic treatment against postmenopausal osteopenia.<b>Design:</b> We used a novel red clover extract (RCE) rich in isoflavone aglycones and probiotics to concomitantly promote uptake and a favorable intestinal bacterial profile to enhance isoflavone bioavailability.
|
28768651 |
2017 |
Osteoporosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
It has been suggested that altered estrogen or estrogen receptor α/β (ERα/β) signaling may be involved in diabetic osteoporosis.
|
29030155 |
2017 |
Osteoporosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Selective estrogen receptor modulators and the vitamin D analogue eldecalcitol block bone loss in male osteoporosis.
|
27974229 |
2017 |
Osteoporosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
The distribution of ESR1 in the osteoporosis group and the control group was determined; the relationship between ESR polymorphisms and BMD was analyzed.
|
27323138 |
2016 |
Osteoporosis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
These genes all displayed estradiol (E2)-dependent induction in human fetal osteoblasts transfected with estrogen receptor-α, and their knockdown altered the expression of known osteoporosis-related genes.
|
25148458 |
2014 |
Osteoporosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
We identified raloxifene, a selective estrogen receptor (ER) modulator currently used in the clinic for prevention of ER-positive breast cancer and osteoporosis in post-menopausal women, as an AhR activator.
|
24481452 |
2014 |