ESR1, estrogen receptor 1, 2099

N. diseases: 1101; N. variants: 185
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0149931
Disease: Migraine Disorders
Migraine Disorders
0.400 GeneticVariation group BEFREE There are significant differences in allelic distributions for rs2234693 and rs9340799 in ESR1 gene between patients with migraine and control subjects. 27778160 2017
CUI: C0149931
Disease: Migraine Disorders
Migraine Disorders
0.400 GeneticVariation group BEFREE Both 325C>G and 594G>A polymorphisms showed no major effects either in males or in females.Based on the statistical data, we conclude some of the ESR1 gene polymorphisms may have major contributions to the pathogenesis of migraine in Caucasian populations. 26334887 2015
CUI: C0149931
Disease: Migraine Disorders
Migraine Disorders
0.400 GeneticVariation group BEFREE Univariate analysis revealed significant associations of polymorphisms in CYP19A1, ESR1, TNFA and PRDM16 genes with migraine susceptibility. 24698360 2014
CUI: C0149931
Disease: Migraine Disorders
Migraine Disorders
0.400 GeneticVariation group BEFREE Three haplotypes in ESR1 were found to be associated with migraine ( P  = 0.004, 0.03, 0.005). 23674830 2013
CUI: C0149931
Disease: Migraine Disorders
Migraine Disorders
0.400 GeneticVariation group BEFREE Potential role of aromatase over estrogen receptor gene polymorphisms in migraine susceptibility: a case control study from North India. 22511967 2012
CUI: C0149931
Disease: Migraine Disorders
Migraine Disorders
0.400 GeneticVariation group BEFREE Effect estimates from an additive model suggest that the ESR-1 594 G>A (pooled OR 1.37; 95% CI 1.02-1.83) and ESR-1 325 C>G (pooled OR 1.16; 95% CI 1.03-1.32) variants are associated with any migraine. 20959426 2010
CUI: C0149931
Disease: Migraine Disorders
Migraine Disorders
0.400 GeneticVariation group BEFREE We found significant association of TT genotype [odds ratio (OR) 3.458, confidence interval (CI) 1.757, 6.806; P = 0.0003] and T allele (OR 1.729, CI 1.309, 2.284; P = 0.0001) of ESR1 PvuII single nucleotide polymorphism with migraine when compared with HC. 19673915 2010
CUI: C0149931
Disease: Migraine Disorders
Migraine Disorders
0.400 Biomarker group BEFREE Our study does not support a major contribution of ESR1 and PGR to the pathogenesis of migraine. 19175383 2009
CUI: C0149931
Disease: Migraine Disorders
Migraine Disorders
0.400 GeneticVariation group BEFREE Using the SUMSTAT program, we observed ESR2-ESR1-FSHR significant gene-gene interaction, suggesting association with the MA/MO phenotype (P = .005; P = .003 in females), and with MA alone (P = .021; P = .030 for females).We corroborated that ESR2-ESR1-FSHR haplotypes interacted for migraine under a model-free hypothesis (empirical P = .010 for the whole sample; P = .001 for females), and the association was stronger for the MA phenotype alone (empirical P = 5.0e-4, under the heterogeneity model; P = .001 for females). 19093296 2009
CUI: C0149931
Disease: Migraine Disorders
Migraine Disorders
0.400 GeneticVariation group BEFREE In this study, we tested the association of two female hormonal genes, progesterone receptor (PGR) and estrogen receptor (ESR1), which were previously reported to be associated with migraine in women. 17609999 2007
CUI: C0149931
Disease: Migraine Disorders
Migraine Disorders
0.400 GeneticVariation group BEFREE No role for estrogen receptor 1 gene intron 1 Pvu II and exon 4 C325G polymorphisms in migraine susceptibility. 16504171 2006
CUI: C0149931
Disease: Migraine Disorders
Migraine Disorders
0.400 GeneticVariation group LHGDN Therefore, we conclude that ESR1 G325C polymorphism is associated with migraine in our population. 16361951 2006
CUI: C0149931
Disease: Migraine Disorders
Migraine Disorders
0.400 GeneticVariation group BEFREE Therefore, we conclude that ESR1 G325C polymorphism is associated with migraine in our population. 16361951 2006
CUI: C0149931
Disease: Migraine Disorders
Migraine Disorders
0.400 GeneticVariation group BEFREE There were no differences in the genotype distributions of the previously migraine-associated SNPs C677T (MTHFR) and G2014A (ESR1) between cases and controls (P-values 0.83 and 0.55, respectively). 17116097 2006
CUI: C0149931
Disease: Migraine Disorders
Migraine Disorders
0.400 GeneticVariation group BEFREE Interaction analysis of the PROGINS variant with our previously reported associated ESR1 594A variant showed that individuals who possessed at least one copy of both risk alleles were 3.2 times more likely to suffer migraine. 15654614 2005
CUI: C0149931
Disease: Migraine Disorders
Migraine Disorders
0.400 GeneticVariation group BEFREE In another publication, other ESR1 variation was associated with migraine. 16179580 2005
CUI: C0149931
Disease: Migraine Disorders
Migraine Disorders
0.400 Biomarker group BEFREE This study thus examined the estrogen receptor 1 (ESRalpha) gene for a potential role in migraine pathogenesis and susceptibility. 15133719 2004
CUI: C0149931
Disease: Migraine Disorders
Migraine Disorders
0.400 GeneticVariation group LHGDN A population-based cohort of 224 migraine sufferers and 224 matched controls were genotyped for the G594A polymorphism located in exon 8 of the ESR1 gene. 15133719 2004
CUI: C0149931
Disease: Migraine Disorders
Migraine Disorders
0.400 Biomarker group CTD_human A population-based cohort of 224 migraine sufferers and 224 matched controls were genotyped for the G594A polymorphism located in exon 8 of the ESR1 gene. 15133719 2004