Coronary Artery Disease
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
There were no differences in expression of estrogen receptor (ER) between three regions of adipose tissue both in men with CAD with and without SHF.
|
30193537 |
2018 |
Coronary Artery Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Correlation between polymorphisms in the estrogen receptor α gene and coronary heart disease: A meta-analysis.
|
27706721 |
2016 |
Coronary Artery Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The current study suggests that ESR1 PvuII polymorphism has an important role in CAD susceptibility.
|
24599688 |
2014 |
Coronary Artery Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Meta-analysis of the association of the rs2234693 and rs9340799 polymorphisms of estrogen receptor alpha gene with coronary heart disease risk in Chinese Han population.
|
23471591 |
2013 |
Coronary Artery Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
There was significant enrichment of ESR1 binding present in multiple datasets near genomic regions associated with breast cancer (7.45-fold, p = 0.001), height (2.45-fold, p = 0.002), multiple sclerosis (5.97-fold, p < 0.0002) and prostate cancer (4.47-fold, p = 0.0008), and suggestive evidence of ESR1 enrichment for regions associated with coronary artery disease, ovarian cancer, Parkinson's disease, polycystic ovarian syndrome and testicular cancer.
|
24171864 |
2013 |
Coronary Artery Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Association between the polymorphism of estrogen receptor α and coronary artery disease in a Chinese population.
|
22284250 |
2012 |
Coronary Artery Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Despite the widespread expression of ERα in vascular tissues, we found no evidence for involvement of common or low-frequency genetic variation throughout the ESR1 gene in modifying risk of CAD, either in the general population or as a function of sex.
|
21984528 |
2011 |
Coronary Artery Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
To test whether estrogen receptor polymorphisms modify the effects of postmenopausal hormone therapy on biomarkers and on risk of coronary heart disease events, stroke, or venous thromboembolism.
|
21106950 |
2011 |
Coronary Artery Disease
|
0.400 |
Biomarker
|
disease |
CTD_human |
Modulation of gene expression by Polyalthia longifolia in postmenopausal women with coronary artery disease: an in vitro study.
|
20559769 |
2010 |
Coronary Artery Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
ESR1 genetic variants, haplotypes and the risk of coronary heart disease and ischemic stroke in the Finnish population: a prospective follow-up study.
|
20153472 |
2010 |
Coronary Artery Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Association of estrogen receptor alpha gene polymorphism with the presence of coronary artery disease documented by coronary angiography.
|
19318036 |
2009 |
Coronary Artery Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
After adjusting for CAD and age, no impacts of ESR1 PvuII and XbaI polymorphisms were found on lipid profile, lipoprotein (a) level, and quantitative CRP either in total population or in subgroups stratified by gender.
|
19446283 |
2009 |
Coronary Artery Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We have previously reported significant association of ER alpha gene (ESR1) variants with more severe coronary artery disease (CAD) in postmenopausal women.
|
19938352 |
2009 |
Coronary Artery Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Inflammatory response of coronary artery disease postmenopausal women is associated with the IVS1-397T > C estrogen receptor alpha polymorphism.
|
19008156 |
2009 |
Coronary Artery Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Qualitative assessment of previous evidence and an updated meta-analysis confirms lack of association between the ESR1 rs2234693 (PvuII) variant and coronary heart disease in men and women.
|
19608186 |
2009 |
Coronary Artery Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
There have been studies examining the association between coronary artery disease and the estrogen receptor alpha (ESR1) gene.
|
18360040 |
2008 |
Coronary Artery Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Gender-specific effect of estrogen receptor-1 gene polymorphisms in coronary artery disease and its angiographic severity in Chinese population.
|
18582450 |
2008 |
Coronary Artery Disease
|
0.400 |
GeneticVariation
|
disease |
LHGDN |
The relationship of the ESR1 gene polymorphisms with the presence of coronary artery disease determined by coronary angiography.
|
18294052 |
2007 |
Coronary Artery Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
Associations of CAD with estrogen receptor alpha (ER alpha) polymorphisms, which may influence sensitivity to estrogen, have been reported for men; the data concerning women are not conclusive.
|
17389465 |
2007 |
Coronary Artery Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The estrogen receptor-1 (ESR1, c.454-397T>C) CC variant genotype is associated with the severity of coronary artery disease (CAD) and an increased risk of myocardial infarction in men.
|
17558892 |
2007 |
Coronary Artery Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The relationship of the ESR1 gene polymorphisms with the presence of coronary artery disease determined by coronary angiography.
|
18294052 |
2007 |
Coronary Artery Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Estrogen receptor 1 gene polymorphisms and coronary artery disease in the Brazilian population.
|
16612467 |
2006 |
Coronary Artery Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Effect of hormone replacement therapy on plasma lipoproteins and apolipoproteins, endothelial function and myocardial perfusion in postmenopausal women with estrogen receptor-alpha IVS1-397 C/C genotype and established coronary artery disease.
|
16612068 |
2006 |
Coronary Artery Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Mutation in the ESR1 (PvuII) was more prevalent in the controls (18 vs. 11%; p=0.062) than in CAD patients, and the mutation identified by the XbaI enzyme in the same receptor was associated with reduced apolipoprotein B levels and low body mass index.
|
16099331 |
2005 |
Coronary Artery Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
This study seeks to investigate the association between the ESR1 haplotype created by the c.454-397 T>C and c.454-351 A>G polymorphisms, the length of the (TA)n repeats, and the angiographic extent of CAD.
|
16159931 |
2005 |