ESR2, estrogen receptor 2, 2100

N. diseases: 528; N. variants: 56
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0025149
Disease: Medulloblastoma
Medulloblastoma
0.350 Biomarker disease BEFREE These findings demonstrate that E2 and environmental estrogens decrease sensitivity of MB to cytotoxic chemotherapeutics, and that ERβ selective and non-selective inhibition of estrogen receptor activity blocks these cytoprotective actions. 28877739 2017
CUI: C0025149
Disease: Medulloblastoma
Medulloblastoma
0.350 Biomarker disease BEFREE In a novel Med ERβ-null knockout model developed by crossing Esr2(-/-) mice with cerebellar granule cell precursor specific Ptch1 conditional knockout mice, the tumor growth rate was significantly decreased in males and females. 25885794 2015
CUI: C0025149
Disease: Medulloblastoma
Medulloblastoma
0.350 Biomarker disease BEFREE In conclusion, inhibition of ERβ considered as a supplemental anticancer therapy, has been found to interfere with cisplatin-induced cytotoxicity in human medulloblastoma cell lines. 22439007 2012
CUI: C0025149
Disease: Medulloblastoma
Medulloblastoma
0.350 Therapeutic disease CTD_human Protective role of 17 β-estradiol on medulloblastoma development in Patched 1 heterozygous mice. 21351254 2010
CUI: C0025149
Disease: Medulloblastoma
Medulloblastoma
0.350 Biomarker disease BEFREE Nuclear ERbeta was also present in human medulloblastoma clinical samples. 19117011 2009
CUI: C0025149
Disease: Medulloblastoma
Medulloblastoma
0.350 Biomarker disease BEFREE Similar to previous studies in normal cerebellar granule cell precursors, these studies demonstrate that the physiological actions of estrogens in MD are mediated by ERbeta. 19008315 2009