|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
Recently, the beneficial role of selective ERβ activation in the regulation of metabolic homeostasis in obesity has been demonstrated, but its importance is still controversial.
|
31811898 |
2020 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
ERβ activation in obesity improves whole body metabolism via adipose tissue function and enhanced mitochondria biogenesis.
|
30342056 |
2019 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
These data highlight a new role for ER-β in adipose biology and its potential to be a safer alternative peripheral therapeutic target for obesity.-Ponnusamy, S., Tran, Q. T., Harvey, I., Smallwood, H. S., Thiyagarajan, T., Banerjee, S., Johnson, D. L., Dalton, J. T., Sullivan, R. D., Miller, D. D., Bridges, D., Narayanan, R. Pharmacologic activation of estrogen receptor β increases mitochondrial function, energy expenditure, and brown adipose tissue.
|
27733447 |
2017 |
|
Obesity
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
These results suggest that the selective activation of ERβ in ovariectomized mice may have protective effects against obesity and depressive-like behaviour without causing an increase in uterine weight.
|
28680060 |
2017 |
|
Obesity
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
SKBR3 cell treatment with OB sera plus Herceptin increased ERβ expression three-fold.
|
26709918 |
2015 |
|
Obesity
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
We found novel associations between the REV-ERB-ALPHA1 rs2314339 genotype and obesity in two independent populations: in Spanish Mediterranean and North American groups, the frequency of the minor-allele-carriers (AA+ AG) was significantly lower in the "abdominally obese" group than in those of the "nonabdominally obese" group (p < 0.05).
|
24173768 |
2014 |
|
Obesity
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
We aimed to identify new polymorphisms in the promoter of REV-ERB ALPHA and tested whether these polymorphisms could be associated with obesity in the Spanish population.
|
25089907 |
2014 |
|
Obesity
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Impact of REV-ERB alpha gene polymorphisms on obesity phenotypes in adult and adolescent samples.
|
22828941 |
2013 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
RGD |
Impact of estradiol, ER subtype specific agonists and genistein on energy homeostasis in a rat model of nutrition induced obesity.
|
22230815 |
2012 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
Treatment of diet-induced obese mice with a REV-ERB agonist decreased obesity by reducing fat mass and markedly improving dyslipidaemia and hyperglycaemia.
|
22460951 |
2012 |
|
Obesity
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
The relationship of three polymorphisms (rs1271572, rs1256049 and rs4986938) and their associated haplotypes in the ESR2 gene with obesity and overweight were evaluated in 561 apparently healthy women (median age 63 years) from the Women's Health Study.
|
19111408 |
2009 |
|
Obesity
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
ESR2 Alu I polymorphism may have a favorable influence on risk factors for cardiovascular disease such as obesity indices and cholesterol levels.
|
19938352 |
2009 |
|
Obesity
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
23 ESR1 and 11 ESR2 tag-SNPs, covering most of the common haplotype variation in each gene according to HAPMAP data, were analysed by Chi2 for association with obesity in a cohort comprising 705 adults with severe obesity and 402 lean individuals.
|
18053221 |
2007 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
The ratio of estrogen receptor alpha to estrogen receptor beta in adipose tissue is associated with leptin production and obesity.
|
17509633 |
2007 |