Precursor B-cell lymphoblastic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In this study, we examined the diagnostic (n = 77) and relapsed (n = 31) pediatric B-cell acute lymphoblastic leukemia (B-ALL) samples for the most common leukemia-associated gene variations CRLF2, JAK2, PAX5 and IL7R using deep sequencing and copy number alterations (CNAs) (CDKN2A/2B, PAX5, RB1, BTG1, ETV6, CSF2RA, IL3RA and CRLF2) by multiplex ligation proximity assay (MLPA), and evaluated for the clonal changes through relapse.
|
31228652 |
2019 |
Precursor B-cell lymphoblastic leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Regulated Pax5-Etv6 target genes identified in these B-ALLs encode proteins implicated in pre-B-cell receptor (BCR) signaling and migration/adhesion, which could contribute to the proliferation, survival, and tissue infiltration of leukemic B cells.
|
28219927 |
2017 |
Precursor B-cell lymphoblastic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The most common rearrangement in childhood precursor B-cell acute lymphoblastic leukemia is the t(12;21)(p13;q22) translocation resulting in the ETV6-AML1 fusion gene.
|
27540136 |
2016 |
Precursor B-cell lymphoblastic leukemia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Further investigation into the clinical and biological significance of elevated MN1 expression in TEL-AML1(positive) leukemia might provide insight into additional molecular mechanisms contributing to B-ALL and may lead to improved treatment options for patients.
|
26111797 |
2015 |
Precursor B-cell lymphoblastic leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
The role of ETV6 in B-cell acute lymphoblastic leukemia (ALL) has been extensively studied, whereas only rare cases of ETV6 involvement in pediatric T-cell ALL have been described.
|
24577543 |
2014 |
Precursor B-cell lymphoblastic leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
The presence of the type A fusion transcript strongly implies ALL manifestation in ETV6/ABL1-positive hematologic malignancies as minor BCR breakpoint in BCR/ABL1-positive ALL.
|
23171811 |
2013 |
Precursor B-cell lymphoblastic leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
A diagnosis of BCR-ABL1 (p190)-positive and ETV6-RUNX1-positive B-ALL was made, and treatment was initiated according to the AIEOP-BFM-ALL2000 protocol.
|
23491079 |
2013 |
Precursor B-cell lymphoblastic leukemia
|
0.400 |
FusionGene
|
disease |
ORPHANET |
A diagnosis of BCR-ABL1 (p190)-positive and ETV6-RUNX1-positive B-ALL was made, and treatment was initiated according to the AIEOP-BFM-ALL2000 protocol.
|
23491079 |
2013 |
Precursor B-cell lymphoblastic leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
The degree of anemia was significantly different for three distinct groups of patients compared to the remaining patients (mean hemoglobin; T-cell leukemia: 106 g/L versus 76 g/L (precursor B-cell acute lymphoblastic leukemia); within precursor B-cell ALL: TEL-AML1 positive: 68 g/L versus 79 g/L; BCR-ABL positive: 93 g/L versus 76 g/L; each p<0.05).
|
18815194 |
2008 |
Precursor B-cell lymphoblastic leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Persistence of TEL-AML1 fusion gene as minimal residual disease has no additive prognostic value in CD 10 positive B-acute lymphoblastic leukemia: a FISH study.
|
18928518 |
2008 |
Precursor B-cell lymphoblastic leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
TEL gene status was determined for 926 patients with B-precursor ALL enrolled on the Pediatric Oncology Group ALinC 16 trials and patients were observed for a median time of 8 years.
|
18445843 |
2008 |
Precursor B-cell lymphoblastic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Here we explore the clonal evolution of a form of childhood precursor-B cell acute lymphoblastic leukemia that is characterized by a chromosomal translocation generating a TEL-AML1 fusion gene.
|
18202291 |
2008 |
Precursor B-cell lymphoblastic leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
These cells correspond to TEL/AML1(pos) ALL (1/4 pediatric B-precursor ALL).
|
18005092 |
2008 |
Precursor B-cell lymphoblastic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
ETV6-RUNX1 fusion transcripts were detected in 21 of 92 patients (22.8%): 16 with common ALL, 4 with precursor B-cell ALL, and 1 with T-ALL.
|
17889709 |
2007 |
Precursor B-cell lymphoblastic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
A t(12;17)(p13;q12) identifies a distinct TEL rearrangement-negative subtype of precursor-B acute lymphoblastic leukemia.
|
16490598 |
2006 |
Precursor B-cell lymphoblastic leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
A fluorescence in situ hybridization study of TEL-AML1 fusion gene in B-cell acute lymphoblastic leukemia (1984-2001).
|
12850377 |
2003 |
Precursor B-cell lymphoblastic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
TEL is frequently disrupted by chromosomal translocations such as the t(12;21), which is associated with nearly one-fourth of pediatric B cell acute lymphoblastic leukemia.
|
12626745 |
2003 |
Precursor B-cell lymphoblastic leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
The IgH, TCR and TEL-AML1 markers can be used as targets by real-time PCR under the same cycling profile, allowing quantitation of MRD in more 95% of patients with pre-B ALL.
|
12571459 |
2003 |
Precursor B-cell lymphoblastic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The t(12;21)(p13;q22) with the TEL-AML1 fusion gene is present in approximately 25% of children with B-precursor ALL.
|
11841400 |
2002 |
Precursor B-cell lymphoblastic leukemia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The B-precursor ALL was retransplantable and expressed TEL-AML1.
|
12124316 |
2002 |
Precursor B-cell lymphoblastic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The TEL-AML1 fusion which results from the t(12;21) rearrangement in childhood B-precursor acute lymphoblastic leukaemia (B-precursor ALL) is often accompanied by loss of the untranslocated TEL allele.
|
11426627 |
2000 |
Precursor B-cell lymphoblastic leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
However, this group was not representative as it included a high number of relapsed patients compared with the normal incidence in B-precursor ALL [54 in continuous complete remission (CCR) and 36 relapsed patients] and only a slightly better prognosis for TEL/AML1-positive patients was found (not significant) (four relapses in 17 TEL/AML1-positive patients vs. 32 relapses in 73 TEL/AML1-negative patients).
|
11167743 |
2000 |
Precursor B-cell lymphoblastic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Of 166 unselected cases of B-precursor ALL studied by Southern hybridization, 45 cases (27%) showed TEL rearrangement.
|
9823952 |
1998 |
Precursor B-cell lymphoblastic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We show here that a t(9;12)(p24;p13) in a case of early pre-B acute lymphoid leukemia and a t(9;15;12)(p24;q15;p13) in atypical chronic myelogenous leukemia in transformation involve the ETV6 gene at 12p13 and the JAK2 gene at 9p24.
|
9326218 |
1997 |
Precursor B-cell lymphoblastic leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Three patients were positive for TEL-AML1 transcripts.All three had common-ALL.
|
8982044 |
1996 |