MECOM, MDS1 and EVI1 complex locus, 2122

N. diseases: 191; N. variants: 57
Disease: Malignant tumor of colon ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon 		0.330 Biomarker disease BEFREE EVI1 targets ΔNp63 and upregulates the cyclin dependent kinase inhibitor p21 independent of p53 to delay cell cycle progression and cell proliferation in colon cancer cells. 23665236 2013
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon 		0.330 Biomarker disease CTD_human SUMO1 negatively regulates the transcriptional activity of EVI1 and significantly increases its co-localization with EVI1 after treatment with arsenic trioxide. 23770046 2013
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon 		0.330 AlteredExpression disease BEFREE Evi-1 was overexpressed in 53% of human CRC samples, 100% of colon adenoma samples, and 100% of human colon cancer cell lines tested. 22161860 2013
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon 		0.330 Biomarker disease BEFREE A complex molecular axis linking Evi1, miRNA-143 is operational in human colon cancer. 21276449 2011