F2, coagulation factor II, thrombin, 2147

N. diseases: 490; N. variants: 42
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.330 GeneticVariation disease BEFREE We have engineered NEP as a potential therapeutic for AD but found in pre-clinical safety testing that this variant increased prothrombin time (PT) and activated partial thromboplastin time (APTT). 27437944 2016
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.330 GeneticVariation disease BEFREE In this study we analyze the frequencies of Leiden Factor V polymorphism (G1691A), and G20210A of prothrombin (FII) in three cohorts of subjects: patients with Alzheimer's disease (unsuccessful aging), nonagenarians (successful aging) and young healthy controls, to assess whether allelic variants associated to the modification of haemostatic system function, may play a role in the protection or susceptibility to Alzheimer disease, as well as to reach a successful aging. 21424155 2011
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.330 AlteredExpression disease BEFREE ELISA revealed elevated prothrombin levels in prefrontal cortex AD cases that increased with the Braak stage (Control=1.39, I-II=1.76, III-IV=2.28, and V-VI=3.11 ng prothrombin/mg total protein). 16782234 2007
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.330 Biomarker disease CTD_human Non-age related differences in thrombin responses by platelets from male patients with advanced Alzheimer's disease. 8333868 1993