|
Cerebrovascular accident
|
0.500 |
Biomarker
|
group |
BEFREE |
Restoring prothrombin to neurons with a lentiviral gene vector restored astrocyte activation and reduced stroke damage.
|
31453648 |
2020 |
|
Cerebrovascular accident
|
0.500 |
Biomarker
|
group |
BEFREE |
The parameters leukocyte and thrombocyte count, C-reactive protein, fibrinogen, D-dimer, activated partial thromboplastin time (aPTT) and prothrombin time were extracted from hospital-based medical records of patients (n = 60) with sCAD and compared with those of a control group (n = 97) from a prospective observational stroke study.
|
29224120 |
2018 |
|
Cerebrovascular accident
|
0.500 |
Biomarker
|
group |
BEFREE |
Vitamin K antagonists (VKAs) are used for stroke prevention in patients with non-valvular atrial fibrillation (NVAF), but necessitate regular monitoring of prothrombin time via international normalized ratio (INR) testing.
|
28151036 |
2017 |
|
Cerebrovascular accident
|
0.500 |
GeneticVariation
|
group |
GWASCAT |
Genome-wide association analysis of self-reported events in 6135 individuals and 252 827 controls identifies 8 loci associated with thrombosis.
|
26908601 |
2016 |
|
Cerebrovascular accident
|
0.500 |
SusceptibilityMutation
|
group |
CLINVAR |
Prevalence and Geographical Variation of Prothrombin G20210A Mutation in Patients with Cerebral Vein Thrombosis: A Systematic Review and Meta-Analysis.
|
27031503 |
2016 |
|
Cerebrovascular accident
|
0.500 |
GeneticVariation
|
group |
BEFREE |
The frequently assessed hereditary thrombophilia mutations associated with stroke are methylenetetrahydrofolate reductase (MTHFR) c.677C>T, Factor V (F5) c.1691G>A (Leiden), and prothrombin (F2) c.20210G>A.
|
26522268 |
2016 |
|
Cerebrovascular accident
|
0.500 |
GeneticVariation
|
group |
BEFREE |
Tobacco smoking strongly modifies the association of prothrombin G20210A with undetermined stroke: consecutive survivors and population-based controls.
|
25897999 |
2015 |
|
Cerebrovascular accident
|
0.500 |
GeneticVariation
|
group |
BEFREE |
Smoking (OR, 2.48; 95 % CI, 1.20-5.15), the A1691 mutation in factor V gene (OR, 3.64; 95 % CI, 1.31-10.10), and the A20210 mutation in the prothrombin gene (OR, 8.40; 95 % CI 3.35-21.05) were associated with FH of premature stroke (n = 33), while circulating anti-phospholipids to FH of premature myocardial infarction (n = 45; OR, 3.48; 95 % CI, 1.61-7.51).
|
25413729 |
2015 |
|
Cerebrovascular accident
|
0.500 |
GeneticVariation
|
group |
BEFREE |
Stroke prevalence and odds ratio (OR) were assessed for the following parameters: G20210A prothrombin, Arg506Glu factor V Leiden, C677T MTHFR, and 4G/5G PAI-1 polymorphisms; total number of study polymorphisms in a particular subject (genetic sum); and classic vascular risk factors of hypertension, obesity, diabetes mellitus, cigarette smoking, hypercholesterolemia, hypertriglyceridemia, and elevated levels of low-density lipoprotein (LDL) cholesterol and very low-density lipoprotein cholesterol.
|
24189452 |
2014 |
|
Cerebrovascular accident
|
0.500 |
GeneticVariation
|
group |
BEFREE |
An interactive effect between the MTHFR 677TT and F2 20210GA polymorphisms showed an increased risk of stroke.
|
24132798 |
2013 |
|
Cerebrovascular accident
|
0.500 |
GeneticVariation
|
group |
BEFREE |
He had stroke as part of a generalized bleeding-thromboembolic incident caused by combined heterozygote mutation of factor V(Leiden) and prothrombin G20210A, each of which was then found in a heterozygote form in each of the 2 parents.
|
22948176 |
2012 |
|
Cerebrovascular accident
|
0.500 |
GeneticVariation
|
group |
BEFREE |
We suggest that prothrombin mutation but not FV Leiden should be considered as a modest genetic risk factor for large artery disease stroke subtype in the Moroccan population.
|
21701789 |
2012 |
|
Cerebrovascular accident
|
0.500 |
GeneticVariation
|
group |
BEFREE |
Across the population the presence of the FII G20210A mutation (OR: 2.97;95% CI: 1.32-6.69), a history of DVT (OR: 1.04; 95% CI: 1.02-1.06), and oestrogen-containing contraceptive therapy (OR: 1.14; 95% CI: 1.09-1.18) were all associated with stroke of unknown cause after adjustment for other risk factors, This was not the case with PFO.
|
22909823 |
2012 |
|
Cerebrovascular accident
|
0.500 |
GeneticVariation
|
group |
BEFREE |
Basic clinical evaluations for stroke and genotyping for factor V 1691 G-A (factor V Leiden), prothrombin 20210 G-A mutations, and methylenetetrahydrofolate reductase 677 C-T polymorphisms were performed using real-time polymerase chain reaction, with fluorescent melting curve detection analysis.
|
22759687 |
2012 |
|
Cerebrovascular accident
|
0.500 |
GeneticVariation
|
group |
BEFREE |
We reviewed the literature focusing on case-control studies of the 5 most commonly inherited disorders of coagulation: protein C deficiency, protein S deficiency, antithrombin deficiency, and the factor V Leiden and prothrombin gene mutations in patients with stroke.
|
20947844 |
2010 |
|
Cerebrovascular accident
|
0.500 |
GeneticVariation
|
group |
BEFREE |
The factor V Leiden mutation was over-represented in patients with cardioembolic stroke for trend, whereas the prothrombin 20210G-->A variant and the factor XIII polymorphism Val34Leu were not associated with stroke of any subtype.
|
19660184 |
2010 |
|
Cerebrovascular accident
|
0.500 |
GeneticVariation
|
group |
BEFREE |
Ninety-nine patients were tested for the presence of common polymorphisms related to thrombophilia (prothrombin and factor V Leiden) in order to assess genetic risk factors, and several parameters classically associated with vascular disorders (cardiovascular events, brain stroke and antiphospholipid syndrome) were evaluated.
|
19005247 |
2009 |
|
Cerebrovascular accident
|
0.500 |
SusceptibilityMutation
|
group |
CLINVAR |
The genetics of venous thromboembolism. A meta-analysis involving approximately 120,000 cases and 180,000 controls.
|
19652888 |
2009 |
|
Cerebrovascular accident
|
0.500 |
GeneticVariation
|
group |
LHGDN |
[Frequency of prothrombin gene G20210A variant in the 3'-untranslated region in Zhuang ethnic Chinese].
|
15952132 |
2005 |
|
Cerebrovascular accident
|
0.500 |
GeneticVariation
|
group |
BEFREE |
We assessed three genetic thrombophilic markers (mutation of Factor V Leiden [FV G1691A], 677T polymorphism of thermolabile methylenetetrahydrofolate reductase [MTHFR] and G20210A mutation of the prothrombin gene) in 49 pediatric patients with non-stroke CP and compared the findings with 118 apparently healthy controls.
|
15907528 |
2005 |
|
Cerebrovascular accident
|
0.500 |
GeneticVariation
|
group |
LHGDN |
Matched case-control study on factor V Leiden and the prothrombin G20210A mutation in patients with ischemic stroke/transient ischemic attack up to the age of 60 years.
|
15947254 |
2005 |
|
Cerebrovascular accident
|
0.500 |
SusceptibilityMutation
|
group |
CLINVAR |
The prothrombin 3'end formation signal reveals a unique architecture that is sensitive to thrombophilic gain-of-function mutations.
|
15059842 |
2004 |
|
Cerebrovascular accident
|
0.500 |
GeneticVariation
|
group |
LHGDN |
The association between factor V Leiden (FVL) and prothrombin G20210A (PT 20210) mutations and ischemic stroke remains controversial, particularly in young adults with cryptogenic stroke.
|
15116266 |
2004 |
|
Cerebrovascular accident
|
0.500 |
GeneticVariation
|
group |
BEFREE |
The association between factor V Leiden (FVL) and prothrombin G20210A (PT 20210) mutations and ischemic stroke remains controversial, particularly in young adults with cryptogenic stroke.
|
15116266 |
2004 |
|
Cerebrovascular accident
|
0.500 |
Biomarker
|
group |
BEFREE |
A high risk of arterial thrombosis (TIA or stroke) was associated with positivity of IgG-aCL, anti beta 2-GPI, and anti-prothrombin.
|
15370721 |
2004 |