Multivariate analysis showed that prothrombin time activity [odds ratio (OR) 0.519], LHL<sub>15</sub> (OR 0.513), and SUV<sub>mean</sub> (OR 0.168) significantly correlated with liver fibrosis.
In univariate analysis, albumin, prothrombin time, prealbumin, cholinesterase and RBP were significantly altered in those with encephalopathy (p < 0.01), but only prealbumin, cholinesterase and RBP levels were significant predictors in multivariate analysis, and each was linked to the severity of liver fibrosis defined by the Child-Pugh score (all p < 0.001).
Participants carrying the FVL mutation or prothrombinG20210A variant have an increased risk of clinically relevant liver fibrosis, which is even higher in blood group type non-O carriers.
It was far better in assessing liver fibrosis than blood markers such as prothrombin time (r = -0.53), type IV collagen 7s (r = 0.48), hyaluronic acid (r = 0.41), and aspartate aminotransferase to platelets ratio index (APRI) (r = 0.38).