F2, coagulation factor II, thrombin, 2147

N. diseases: 490; N. variants: 42
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0398623
Disease: Thrombophilia
Thrombophilia
0.600 GeneticVariation disease BEFREE Studies in Western countries show that VTE recurrent rates are lower in the presence of a transient provoking factor, older age, female sex and/or hormonal use, while thrombophilia (factor V Leiden or prothrombin mutation) has no predictive role. 30334695 2019
CUI: C0398623
Disease: Thrombophilia
Thrombophilia
0.600 GeneticVariation disease BEFREE The prevalence of the following genetic variants was determined: F5 c.1601G>A (factor V Leiden), F2 c.*97G>A (factor II or prothrombin mutation), F13A1 (factor XIII) c.103G>T, MTHFR (methylenetetrahydrofolate reductase) c.665C>T and c.1286A>C, as well as PAI-1 (plasminogen activator inhibitor 1) c.-816A>G and c.-844G>A as markers of thrombophilia risk, and *2 and *3 alleles of CYP2C9 (cytochrome P450 2C9) and five variants of VKORC1 (vitamin K epoxide reductase complex subunit 1) as markers of warfarin pharmacogenetics. 31187948 2019
CUI: C0398623
Disease: Thrombophilia
Thrombophilia
0.600 Biomarker disease BEFREE During the procedure, we observed increases in prothrombin, fibrinogen and D-dimer concentrations, a slight shortening of APTT and a hypercoagulation shift in the thrombodynamics parameters. 31120933 2019
CUI: C0398623
Disease: Thrombophilia
Thrombophilia
0.600 Biomarker disease BEFREE Clinicians have attempted to quantify the hypercoagulable state produced in various malignancies using common coagulation tests such as prothrombin time, activated partial thromboplastin time, and platelet count; however, due to these tests' focus on individual aspects of coagulation during one specific time point, they have failed to provide clinicians the complete picture of malignancy-associated coagulopathy (MAC). 31108555 2019
CUI: C0398623
Disease: Thrombophilia
Thrombophilia
0.600 AlteredExpression disease BEFREE Platelet activation and hypercoagulable parameters including levels of CD62P and prothrombin fragment 1 + 2 were analyzed by flow cytometry and ELISA, respectively. 30988349 2019
CUI: C0398623
Disease: Thrombophilia
Thrombophilia
0.600 GeneticVariation disease BEFREE The child was also carrier of heterozygous prothrombin G20210A variant.Severe venous thromboembolism can occur in otherwise healthy children with complex inherited thrombophilia. 29536478 2018
CUI: C0398623
Disease: Thrombophilia
Thrombophilia
0.600 GeneticVariation disease BEFREE All participants underwent screening for thrombophilia-associated polymorphisms including factor V Leiden (FVL), prothrombin G20210A (PTG), factor V H1299 R (factor V HR2), factor XIII V34 L, β-fibrinogen-455 G>A, plasminogen activator inhibitor-1 4G/5G, human platelet antigen-1 a/b, methylene tetrahydrofolate reductase (MTHFR) C677 T, MTHFR A1298C, angiotensin-converting enzyme I/D, apolipoprotein B R3500Q, and apolipoprotein E (Apo E). 27729560 2018
CUI: C0398623
Disease: Thrombophilia
Thrombophilia
0.600 GeneticVariation disease BEFREE Ancillary testing revealed inherited thrombophilia (Prothrombin 20,210 G > A and MTHFR 677 C > T mutation). 29299826 2018
CUI: C0398623
Disease: Thrombophilia
Thrombophilia
0.600 GeneticVariation disease BEFREE However, the use of DOACs in unusual VTE, including cerebral venous thrombosis (CVT) and splanchnic venous thrombosis (SVT), and in patients with biological thrombophilia including minor thrombophilia (Factor V Leiden and prothrombin G20210A), major innate thrombophilia (protein C and S deficiency, and antithrombin) and major acquired thrombophilia (antiphospholipid syndrome [APS]), remains controversial due to the paucity of available data. 29402471 2018
CUI: C0398623
Disease: Thrombophilia
Thrombophilia
0.600 Biomarker disease BEFREE Routine assessment of coagulation activation markers: fibrinogen, D-dimer, prothrombin fragments 1 + 2 (F1 + 2), thrombin-antithrombin complexes (TAT) and fibrin monomer complexes (FMC) was performed every 5 weeks in the study group to detect a possible pathological state of hypercoagulability. 29032523 2018
CUI: C0398623
Disease: Thrombophilia
Thrombophilia
0.600 Biomarker disease BEFREE Other biomarkers reviewed, which did not consistently demonstrate significant associations with VTE included prothrombin fragments F1 + 2, factor VIII, protein C, protein S, von Willebrand antigen and activity, antithrombin, thrombin antithrombin complex, antiphospholopid antibody, plasminogen activator inhibitor, tissue factor pathway inhibitor and several variants associated with known hypercoagulable states (factor V Leiden, prothrombin gene variant, methylenetetrahydrofolate reductase variant). 29407626 2018
CUI: C0398623
Disease: Thrombophilia
Thrombophilia
0.600 GeneticVariation disease BEFREE The influence of thrombosis on the prognosis of patients with hepatocellular carcinoma (HCC) after liver transplantation (LT) and the role of the commonest inherited thrombophilia abnormalities factor V Leiden and prothrombin G20210A in the development of thrombosis are unknown. 29073275 2017
CUI: C0398623
Disease: Thrombophilia
Thrombophilia
0.600 GeneticVariation disease BEFREE Objectives We aimed to elucidate the clinical and biochemical characteristics of thrombophilia associated with antithrombin resistance in a large Serbian family with the prothrombin Belgrade mutation. 28075532 2017
CUI: C0398623
Disease: Thrombophilia
Thrombophilia
0.600 GeneticVariation disease BEFREE The important polymorphisms leading to inherited thrombophilia are Factor V Leiden (FVL), Prothrombin G20210A and MTHFR C677T and A1298C. 26135458 2016
CUI: C0398623
Disease: Thrombophilia
Thrombophilia
0.600 GeneticVariation disease BEFREE Codon 596 (CGG) of prothrombin is a hot spot for mutations, which constitute a new and relatively frequent cause of inherited thrombophilia. 27013614 2016
CUI: C0398623
Disease: Thrombophilia
Thrombophilia
0.600 GeneticVariation disease BEFREE This review of prothrombin G20210A prevalence may guide resourceful screening for identification of hereditary thrombophilia in female populations of interest with hypercoagulable states. 27058219 2016
CUI: C0398623
Disease: Thrombophilia
Thrombophilia
0.600 GeneticVariation disease BEFREE The associations of the following mutations in inherited thrombophilias and IVF outcomes were explored: factor V Leiden (FVL), prothrombin gene G20210A mutation (PGM), 5,10-methylentetrahydrofolate reductase (MTHFR) C677T, MTHFR (A1298C) and activated protein C resistance (APCR). 27216921 2016
CUI: C0398623
Disease: Thrombophilia
Thrombophilia
0.600 GeneticVariation disease BEFREE The rare loss-of-function mutations of the genes encoding natural anticoagulant proteins (i. e. protein C, protein S and antithrombin) and the more common gain-of-function polymorphisms factor V Leiden and prothrombin G20210A are the main genetic determinants of thrombophilia. 26018405 2015
CUI: C0398623
Disease: Thrombophilia
Thrombophilia
0.600 GeneticVariation disease BEFREE To identify inherited factors: Protein C (PC), protein S (PS), antithrombin (AT), plasminogen (Plg), the activated PC resistance (APCR), prothrombin (PT) mutation G20210 A (PTG20210 A) and methylenetetrahydrofolate reductase C677 T polymorphism (MTHFR C677 T), as well as acquired-risk factors such as: diabetes mellitus, surgeries, smoking, obesity, hypertension, trauma, alcoholism, family history; and their association, in Mexican patients with diagnostic of thrombophilia. 26315791 2015
CUI: C0398623
Disease: Thrombophilia
Thrombophilia
0.600 GeneticVariation disease BEFREE This work aimed to study the FV Leiden and the prothrombin gene polymorphism in adult Egyptian patients with acute leukemia and their importance in thrombophilia screening. 25260809 2014
CUI: C0398623
Disease: Thrombophilia
Thrombophilia
0.600 GeneticVariation disease BEFREE Also, our results show that the FII C20221T is a rare variant in this population and therefore, routine thrombophilia screening should not include screening for this genotype. 25316662 2014
CUI: C0398623
Disease: Thrombophilia
Thrombophilia
0.600 GeneticVariation disease BEFREE The investigation for thrombophilia resulted with the combined presence of heterozygote mutation in factor V Leiden and prothrombin 20210 genes. 24612313 2014
CUI: C0398623
Disease: Thrombophilia
Thrombophilia
0.600 GeneticVariation disease BEFREE The most common forms of familial thrombophilia are factor V Leiden (FVL) and prothrombin mutation (PTM). 23054468 2013
CUI: C0398623
Disease: Thrombophilia
Thrombophilia
0.600 GeneticVariation disease BEFREE Thrombophilia that is common among Caucasians is caused by genetic polymorphisms of coagulation factor V Leiden (R506Q) and prothrombin G20210A. 23301217 2013
CUI: C0398623
Disease: Thrombophilia
Thrombophilia
0.600 GeneticVariation disease BEFREE FVL and PTM mutations were high in cancer patients; the presence of inherited thrombophilia was low with risk factors of surgery and immobilization. 23358198 2013