Thrombophilia
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Studies in Western countries show that VTE recurrent rates are lower in the presence of a transient provoking factor, older age, female sex and/or hormonal use, while thrombophilia (factor V Leiden or prothrombin mutation) has no predictive role.
|
30334695 |
2019 |
Thrombophilia
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The prevalence of the following genetic variants was determined: F5 c.1601G>A (factor V Leiden), F2 c.*97G>A (factor II or prothrombin mutation), F13A1 (factor XIII) c.103G>T, MTHFR (methylenetetrahydrofolate reductase) c.665C>T and c.1286A>C, as well as PAI-1 (plasminogen activator inhibitor 1) c.-816A>G and c.-844G>A as markers of thrombophilia risk, and *2 and *3 alleles of CYP2C9 (cytochrome P450 2C9) and five variants of VKORC1 (vitamin K epoxide reductase complex subunit 1) as markers of warfarin pharmacogenetics.
|
31187948 |
2019 |
Thrombophilia
|
0.600 |
Biomarker
|
disease |
BEFREE |
During the procedure, we observed increases in prothrombin, fibrinogen and D-dimer concentrations, a slight shortening of APTT and a hypercoagulation shift in the thrombodynamics parameters.
|
31120933 |
2019 |
Thrombophilia
|
0.600 |
Biomarker
|
disease |
BEFREE |
Clinicians have attempted to quantify the hypercoagulable state produced in various malignancies using common coagulation tests such as prothrombin time, activated partial thromboplastin time, and platelet count; however, due to these tests' focus on individual aspects of coagulation during one specific time point, they have failed to provide clinicians the complete picture of malignancy-associated coagulopathy (MAC).
|
31108555 |
2019 |
Thrombophilia
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Platelet activation and hypercoagulable parameters including levels of CD62P and prothrombin fragment 1 + 2 were analyzed by flow cytometry and ELISA, respectively.
|
30988349 |
2019 |
Thrombophilia
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The child was also carrier of heterozygous prothrombin G20210A variant.Severe venous thromboembolism can occur in otherwise healthy children with complex inherited thrombophilia.
|
29536478 |
2018 |
Thrombophilia
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
All participants underwent screening for thrombophilia-associated polymorphisms including factor V Leiden (FVL), prothrombin G20210A (PTG), factor V H1299 R (factor V HR2), factor XIII V34 L, β-fibrinogen-455 G>A, plasminogen activator inhibitor-1 4G/5G, human platelet antigen-1 a/b, methylene tetrahydrofolate reductase (MTHFR) C677 T, MTHFR A1298C, angiotensin-converting enzyme I/D, apolipoprotein B R3500Q, and apolipoprotein E (Apo E).
|
27729560 |
2018 |
Thrombophilia
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Ancillary testing revealed inherited thrombophilia (Prothrombin 20,210 G > A and MTHFR 677 C > T mutation).
|
29299826 |
2018 |
Thrombophilia
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
However, the use of DOACs in unusual VTE, including cerebral venous thrombosis (CVT) and splanchnic venous thrombosis (SVT), and in patients with biological thrombophilia including minor thrombophilia (Factor V Leiden and prothrombin G20210A), major innate thrombophilia (protein C and S deficiency, and antithrombin) and major acquired thrombophilia (antiphospholipid syndrome [APS]), remains controversial due to the paucity of available data.
|
29402471 |
2018 |
Thrombophilia
|
0.600 |
Biomarker
|
disease |
BEFREE |
Routine assessment of coagulation activation markers: fibrinogen, D-dimer, prothrombin fragments 1 + 2 (F1 + 2), thrombin-antithrombin complexes (TAT) and fibrin monomer complexes (FMC) was performed every 5 weeks in the study group to detect a possible pathological state of hypercoagulability.
|
29032523 |
2018 |
Thrombophilia
|
0.600 |
Biomarker
|
disease |
BEFREE |
Other biomarkers reviewed, which did not consistently demonstrate significant associations with VTE included prothrombin fragments F1 + 2, factor VIII, protein C, protein S, von Willebrand antigen and activity, antithrombin, thrombin antithrombin complex, antiphospholopid antibody, plasminogen activator inhibitor, tissue factor pathway inhibitor and several variants associated with known hypercoagulable states (factor V Leiden, prothrombin gene variant, methylenetetrahydrofolate reductase variant).
|
29407626 |
2018 |
Thrombophilia
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The influence of thrombosis on the prognosis of patients with hepatocellular carcinoma (HCC) after liver transplantation (LT) and the role of the commonest inherited thrombophilia abnormalities factor V Leiden and prothrombin G20210A in the development of thrombosis are unknown.
|
29073275 |
2017 |
Thrombophilia
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Objectives We aimed to elucidate the clinical and biochemical characteristics of thrombophilia associated with antithrombin resistance in a large Serbian family with the prothrombin Belgrade mutation.
|
28075532 |
2017 |
Thrombophilia
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The important polymorphisms leading to inherited thrombophilia are Factor V Leiden (FVL), Prothrombin G20210A and MTHFR C677T and A1298C.
|
26135458 |
2016 |
Thrombophilia
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Codon 596 (CGG) of prothrombin is a hot spot for mutations, which constitute a new and relatively frequent cause of inherited thrombophilia.
|
27013614 |
2016 |
Thrombophilia
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
This review of prothrombin G20210A prevalence may guide resourceful screening for identification of hereditary thrombophilia in female populations of interest with hypercoagulable states.
|
27058219 |
2016 |
Thrombophilia
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The associations of the following mutations in inherited thrombophilias and IVF outcomes were explored: factor V Leiden (FVL), prothrombin gene G20210A mutation (PGM), 5,10-methylentetrahydrofolate reductase (MTHFR) C677T, MTHFR (A1298C) and activated protein C resistance (APCR).
|
27216921 |
2016 |
Thrombophilia
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The rare loss-of-function mutations of the genes encoding natural anticoagulant proteins (i. e. protein C, protein S and antithrombin) and the more common gain-of-function polymorphisms factor V Leiden and prothrombin G20210A are the main genetic determinants of thrombophilia.
|
26018405 |
2015 |
Thrombophilia
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
To identify inherited factors: Protein C (PC), protein S (PS), antithrombin (AT), plasminogen (Plg), the activated PC resistance (APCR), prothrombin (PT) mutation G20210 A (PTG20210 A) and methylenetetrahydrofolate reductase C677 T polymorphism (MTHFR C677 T), as well as acquired-risk factors such as: diabetes mellitus, surgeries, smoking, obesity, hypertension, trauma, alcoholism, family history; and their association, in Mexican patients with diagnostic of thrombophilia.
|
26315791 |
2015 |
Thrombophilia
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
This work aimed to study the FV Leiden and the prothrombin gene polymorphism in adult Egyptian patients with acute leukemia and their importance in thrombophilia screening.
|
25260809 |
2014 |
Thrombophilia
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Also, our results show that the FII C20221T is a rare variant in this population and therefore, routine thrombophilia screening should not include screening for this genotype.
|
25316662 |
2014 |
Thrombophilia
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The investigation for thrombophilia resulted with the combined presence of heterozygote mutation in factor V Leiden and prothrombin 20210 genes.
|
24612313 |
2014 |
Thrombophilia
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The most common forms of familial thrombophilia are factor V Leiden (FVL) and prothrombin mutation (PTM).
|
23054468 |
2013 |
Thrombophilia
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Thrombophilia that is common among Caucasians is caused by genetic polymorphisms of coagulation factor V Leiden (R506Q) and prothrombin G20210A.
|
23301217 |
2013 |
Thrombophilia
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
FVL and PTM mutations were high in cancer patients; the presence of inherited thrombophilia was low with risk factors of surgery and immobilization.
|
23358198 |
2013 |