Autoimmune Diseases
|
0.100 |
GeneticVariation
|
group |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
Hypothyroidism
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
AUTOIMMUNE DISEASE, SUSCEPTIBILITY TO, 6
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
AUTOIMMUNE DISEASE, MULTISYSTEM, INFANTILE-ONSET, 1
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
AUTOIMMUNE DISEASE, MULTISYSTEM, INFANTILE-ONSET, 2
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
Thyroid stimulating hormone measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Genome-wide analyses identify a role for SLC17A4 and AADAT in thyroid hormone regulation.
|
30367059 |
2018 |
Hypothyroidism
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Detection and interpretation of shared genetic influences on 42 human traits.
|
27182965 |
2016 |
Respiratory Function Tests
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Genome-wide association studies identify CHRNA5/3 and HTR4 in the development of airflow obstruction.
|
22837378 |
2012 |
Respiratory Function Tests
|
0.100 |
GeneticVariation
|
phenotype |
GWASDB |
Genome-wide association studies identify CHRNA5/3 and HTR4 in the development of airflow obstruction.
|
22837378 |
2012 |
Adenomatous Polyposis Coli
|
0.030 |
Biomarker
|
disease |
BEFREE |
Loss of Spata13, also known as the adenomatous polyposis coli exchange factor Asef2, has no identifiable phenotype although it has been shown to reduce the number and size of intestinal tumours in Apc (Min/+) mice.
|
31020388 |
2019 |
Adenomatous Polyposis Coli
|
0.030 |
Biomarker
|
disease |
BEFREE |
We observed that the APC-Asef/Asef2 complex induces c-Jun amino-terminal kinase-mediated transactivation of matrix metalloproteinase 9, and is required for the invasive activity of colorectal tumour cells.
|
19893577 |
2009 |
Adenomatous Polyposis Coli
|
0.030 |
Biomarker
|
disease |
BEFREE |
Furthermore, RNA interference experiments showed that Asef2 is required for migration of colorectal tumor cells expressing truncated APC.
|
17599059 |
2007 |
Mammary Neoplasms
|
0.010 |
Biomarker
|
group |
BEFREE |
Corresponding tumour-derived DNA available from 5 of these 7 women had elevated methylation within the BRCA1 and SPHK2 promoter region and decreased methylation within the ADAP1, IGF2BP3 and SPATA13 promoter region when compared with the other breast tumours.
|
30423315 |
2018 |
Differentiated Thyroid Gland Carcinoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
A possible role in DTC susceptibility in the Italian populations was also found for rs13184587 (ARSB) (P = 8.54 × 10(-6)) and rs1220597 (SPATA13) (P = 3.25 × 10(-6)).
|
25029422 |
2014 |
Primary differentiated carcinoma of thyroid gland
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
A possible role in DTC susceptibility in the Italian populations was also found for rs13184587 (ARSB) (P = 8.54 × 10(-6)) and rs1220597 (SPATA13) (P = 3.25 × 10(-6)).
|
25029422 |
2014 |
Adenoma
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Here, we show that Asef and Asef2 expression is aberrantly enhanced in intestinal adenomas and tumours.
|
19893577 |
2009 |
Tumor Progression
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
These results suggest that Asef and Asef2 have a crucial role in intestinal adenoma formation and tumour progression, and might be promising molecular targets for the treatment of colorectal tumours.
|
19893577 |
2009 |
Intestinal adenoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
These results suggest that Asef and Asef2 have a crucial role in intestinal adenoma formation and tumour progression, and might be promising molecular targets for the treatment of colorectal tumours.
|
19893577 |
2009 |
Colorectal Neoplasms
|
0.010 |
GeneticVariation
|
group |
LHGDN |
Furthermore, RNA interference experiments showed that Asef2 is required for migration of colorectal tumor cells expressing truncated APC.
|
17599059 |
2007 |