FGF2, fibroblast growth factor 2, 2247

N. diseases: 635; N. variants: 7
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0017638
Disease: Glioma
Glioma
0.400 Biomarker disease BEFREE Reprogramming COX-2, mPGES-1 and CYP4A mediated-AA metabolism in glioma by flavonoid ISL inhibits the angiogenic Akt- FGF-2/TGF-β/VEGF signaling through ceRNA effect of miR-194-5p and lncRNA NEAT1, and may serve as a novel therapeutic strategy for human glioma. 31438982 2019
CUI: C0017638
Disease: Glioma
Glioma
0.400 AlteredExpression disease BEFREE Here, siRNA was used to silence the expression of bFGF in glioma cell lines including U87 and U251 followed by chemotherapy of temozolomide (TMZ). 27189511 2016
CUI: C0017638
Disease: Glioma
Glioma
0.400 Biomarker disease BEFREE Based on our previous successful construction of a lentivirus-mediated alphastatin (an endogenous angiogenesis inhibitor) gene transfer system and our findings that alphastatin exhibited potent inhibitory effects on the migration and differentiation of human umbilical vein endothelial cell lines (HUVECs) induced by vascular endothelial growth factor (VEGF) or basic fibroblast growth factor (bFGF) in vitro, here, we investigated the effect of using lentiviral vectors to overexpress alphastatin in human glioma cells to show whether sustained long-term expression of alphastatin diminishes tumor growth in a xenograft glioma model. 23242200 2013
CUI: C0017638
Disease: Glioma
Glioma
0.400 AlteredExpression disease BEFREE An optimal siRNA sequence specific for bFGF mRNA was cloned into an adenoviral vector and transfected into three glioma cell lines: U251, A172, and LN229. 20221717 2011
CUI: C0017638
Disease: Glioma
Glioma
0.400 Biomarker disease BEFREE Our results offer a potential mechanism for using Ad-bFGF-siRNA as a gene therapy for glioma. 21906308 2011
CUI: C0017638
Disease: Glioma
Glioma
0.400 Biomarker disease BEFREE In this study, a bFGF-targeted siRNA was delivered to the glioma cell line, U251, using adenovirus (Ad-bFGF-siRNA) and the expression of connexin 43 and its phosphorylation state were evaluated. 20074329 2010
CUI: C0017638
Disease: Glioma
Glioma
0.400 Biomarker disease BEFREE A glioblastoma stem cell (GSC) line, GSC11, grows as neurospheres in serum-free media supplemented with EGF (epidermal growth factor) and bFGF (basic fibroblast growth factor), and, if implanted in nude mice brains, will recapitulate high-grade glial tumors. 20199106 2010
CUI: C0017638
Disease: Glioma
Glioma
0.400 AlteredExpression disease LHGDN We present a positive correlation between the autocrine expression of YY1 and TGF-beta 1, IGF-1 and FGF-2, known to be involved in the progression of gliomas and meningiomas. 19235591 2009
CUI: C0017638
Disease: Glioma
Glioma
0.400 Biomarker disease BEFREE We present a positive correlation between the autocrine expression of YY1 and TGF-beta 1, IGF-1 and FGF-2, known to be involved in the progression of gliomas and meningiomas. 19235591 2009
CUI: C0017638
Disease: Glioma
Glioma
0.400 Biomarker disease BEFREE In particular, we demonstrate that HMW FGF-2 has unique features in inhibiting glioma cell proliferation. 18930044 2008
CUI: C0017638
Disease: Glioma
Glioma
0.400 Biomarker disease BEFREE The G-rich promoter and G-rich coding sequence of basic fibroblast growth factor are the targets of thalidomide in glioma. 18687660 2008
CUI: C0017638
Disease: Glioma
Glioma
0.400 AlteredExpression disease BEFREE The regulator of fibroblast growth factor 2 (FGF-2) transcription (RFT) has been reported to be a transcriptional repressor of FGF-2 and induce glioma cell death by its overexpression. 15081425 2004
CUI: C0017638
Disease: Glioma
Glioma
0.400 Therapeutic disease CTD_human Phase II trial of the antiangiogenic agent thalidomide in patients with recurrent high-grade gliomas. 10673511 2000
CUI: C0017638
Disease: Glioma
Glioma
0.400 Biomarker disease BEFREE Under the third condition (0.5% FCS plus 10 ng/ml basic fibroblast growth factor), astrocytes gained the ability to form colonies in soft agarose and had abnormal chromosome numbers similar to cells in the first two conditions but did not form tumors in nude mice or overexpress glioma-associated genes. 10074901 1999
CUI: C0017638
Disease: Glioma
Glioma
0.400 Biomarker disease BEFREE These results strongly suggest that serum and bFGF control glioma invasion by inducing synthesis of Ets-1 transcription factor, which directly up-regulates expression of uPA in glioma cells. 10211993 1999
CUI: C0017638
Disease: Glioma
Glioma
0.400 AlteredExpression disease BEFREE A hybrid luciferase gene directed by rat FGF-2 5'-flanking DNA (-1,058/+54) was expressed in rat glioma C6, heart myoblast H9c2, and human astrocytoma U87-MG cells after gene transfer. 9048734 1997
CUI: C0017638
Disease: Glioma
Glioma
0.400 AlteredExpression disease BEFREE This study shows that the human glioma cell lines U-87MG and U-251MG, which express high levels of bFGF and its receptor, can be induced to undergo apoptosis when cultured with 3H3 MAb. 8929497 1996
CUI: C0017638
Disease: Glioma
Glioma
0.400 AlteredExpression disease BEFREE Unlike in astrocytes, changing the cell density of glioma cell cultures does not affect the levels of bFGF protein and mRNA. bFGF luciferase constructs were expressed at the same level in high- or low-density cultures of glioma cells, indicating altered regulation of the bFGF gene promoter. 8637898 1996
CUI: C0017638
Disease: Glioma
Glioma
0.400 AlteredExpression disease BEFREE RT-PCR demonstrated the co-expression of bFGF and FGFR mRNAs in five glioma cell lines examined. 8674845 1995
CUI: C0017638
Disease: Glioma
Glioma
0.400 Biomarker disease BEFREE Among those 4 growth factors, the mRNA levels of VEGF, but not those of transforming growth factors alpha and beta and basic fibroblast growth factor, correlated significantly with vascularity in both gliomas (correlation coefficient r = 0.499; P < 0.05) and meningiomas (correlation coefficient r = 0.779; P < 0.001). 7532545 1995
CUI: C0017638
Disease: Glioma
Glioma
0.400 AlteredExpression disease BEFREE To analyze the inhibition of bFGF expression, phosphorothioated bFGF antisense oligodeoxynucleotides were added to cultures of the U-87 human glioma cell line. 8559302 1995
CUI: C0017638
Disease: Glioma
Glioma
0.400 AlteredExpression disease BEFREE There was significant correlation between the expression level of basic fibroblast growth factor (basic FGF) and that of FGFR-1 in tissues of human glioma (Spearman's test, P < 0.05). 8177381 1994
CUI: C0017638
Disease: Glioma
Glioma
0.400 Biomarker disease BEFREE The present study with two model systems of tumor angiogenesis suggests that the angiogenesis of some human glioma cell lines is mediated by bFGF, possibly via paracrine control. 7686924 1993