FGF2, fibroblast growth factor 2, 2247

N. diseases: 635; N. variants: 7
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0085109
Disease: Corneal Neovascularization
Corneal Neovascularization
0.380 AlteredExpression disease BEFREE Subconjunctival injection by 1 μg HHC successfully inhibited gene-induced CorNV in rats. bFGF and VEGF protein expression were reduced after 6 days. 28393322 2018
CUI: C0085109
Disease: Corneal Neovascularization
Corneal Neovascularization
0.380 Biomarker disease BEFREE Fibroblast growth factor-2 drives and maintains progressive corneal neovascularization following HSV-1 infection. 28378806 2018
CUI: C0085109
Disease: Corneal Neovascularization
Corneal Neovascularization
0.380 Biomarker disease BEFREE Joint downregulation of bFGF, P<sub>2</sub>X<sub>2</sub>, bFGF, and LYVE-1 constitutes a mechanism that induces greater and longer inhibition of corneal angiogenesis. 29265937 2018
CUI: C0085109
Disease: Corneal Neovascularization
Corneal Neovascularization
0.380 AlteredExpression disease BEFREE BCL-10 KO mice exhibited reduced alkali-induced CrNV by suppressing intracorneal macrophage infiltration, which subsequently led to decreased VEGF-A and bFGF expression, suggesting that BCL-10 may become a potential clinical intervening target of CrNV. 29515217 2018
CUI: C0085109
Disease: Corneal Neovascularization
Corneal Neovascularization
0.380 Biomarker disease BEFREE A basic fibroblast growth factor-impregnated gelatin hydrogel sheet was implanted into the rabbit cornea to induce corneal neovascularization. 29533953 2018
CUI: C0085109
Disease: Corneal Neovascularization
Corneal Neovascularization
0.380 Biomarker disease BEFREE Comparison of effect of CL1-R2, bevacizumab, or aflibercept or IgG1 (control) injections in early and late treatment schemes on evolution of VEGF- or FGF2-induced rabbit CNV was performed. 29860455 2018
CUI: C0085109
Disease: Corneal Neovascularization
Corneal Neovascularization
0.380 Biomarker disease BEFREE In conclusion, angiogenic potential of COE is greater than that of CCE and FGF2 is a candidate involved in the induction of corneal neovascularization after COE sheet transplantation. 17904552 2007
CUI: C0085109
Disease: Corneal Neovascularization
Corneal Neovascularization
0.380 Biomarker disease LHGDN A soluble EphA2-Fc receptor inhibits VEGF-, but not basic fibroblast growth factor-induced endothelial cell survival, migration, sprouting, and corneal angiogenesis. 12496364 2002
CUI: C0085109
Disease: Corneal Neovascularization
Corneal Neovascularization
0.380 Biomarker disease CTD_human Experiments examining thalidomide's enantiomers reveal-that the S(-)-enantiomer has the strongest antiangiogenic activity in VEGF-induced and bFGF-induced corneal neovascularization. 9301478 1997