FGF2, fibroblast growth factor 2, 2247

N. diseases: 635; N. variants: 7
Disease: Age related macular degeneration ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0242383
Disease: Age related macular degeneration
Age related macular degeneration 		0.040 Biomarker disease BEFREE The bFGF angiogenic protein may therefore be an attractive target to treat ARMD. 28298893 2017
CUI: C0242383
Disease: Age related macular degeneration
Age related macular degeneration 		0.040 GeneticVariation disease BEFREE A variant located at the 3' UTR of the FGF2 gene (rs6820411) was highly associated with atrophic AMD, and the functional SNP rs3112831 at ABCA4 showed a marginal association with the disease. 21106043 2011
CUI: C0242383
Disease: Age related macular degeneration
Age related macular degeneration 		0.040 Biomarker disease BEFREE Our findings support the hypothesis that there are two different FGFR-1- and FGFR-2-dependent pathways that modulate the role of bFGF in induction of neovascularisation in AMD. 16188231 2005
CUI: C0242383
Disease: Age related macular degeneration
Age related macular degeneration 		0.040 Biomarker disease BEFREE This suggests that FGF2 protects photoreceptors from oxidative damage, which may play a role in complex genetic diseases such as age-related macular degeneration. 11549604 2001