FGF2, fibroblast growth factor 2, 2247

N. diseases: 635; N. variants: 7
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0021368
Disease: Inflammation
Inflammation
0.510 Therapeutic phenotype CTD_human The supplementation of FGF-2 and BDNF attenuated various parameters of inflammation, including astrocytosis, microcytosis and IL-1β expression. 21087489 2010
CUI: C0021368
Disease: Inflammation
Inflammation
0.510 Biomarker phenotype RGD Strain-dependent increases in retinal inflammatory proteins and photoreceptor FGF-2 expression in streptozotocin-induced diabetic rats. 19474406 2009
CUI: C0021368
Disease: Inflammation
Inflammation
0.510 Biomarker phenotype LHGDN Down-modulation of monocyte transendothelial migration and endothelial adhesion molecule expression by fibroblast growth factor: reversal by the anti-angiogenic agent SU6668. 12057924 2002
CUI: C0018800
Disease: Cardiomegaly
Cardiomegaly
0.500 Biomarker phenotype RGD Parallel up-regulation of FGF-2 and hyaluronan during development of cardiac hypertrophy in rat. 18196276 2008
CUI: C0018800
Disease: Cardiomegaly
Cardiomegaly
0.500 Biomarker phenotype CTD_human Fibroblast growth factor-2 mediates pressure-induced hypertrophic response. 10491406 1999
CUI: C0017638
Disease: Glioma
Glioma
0.400 Biomarker disease BEFREE Reprogramming COX-2, mPGES-1 and CYP4A mediated-AA metabolism in glioma by flavonoid ISL inhibits the angiogenic Akt- FGF-2/TGF-β/VEGF signaling through ceRNA effect of miR-194-5p and lncRNA NEAT1, and may serve as a novel therapeutic strategy for human glioma. 31438982 2019
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.400 Biomarker disease BEFREE FGF-2 is a driving force for chromosomal instability and a stromal factor associated with adverse clinico-pathological features in prostate cancer. 29887238 2018
CUI: C0017638
Disease: Glioma
Glioma
0.400 AlteredExpression disease BEFREE Here, siRNA was used to silence the expression of bFGF in glioma cell lines including U87 and U251 followed by chemotherapy of temozolomide (TMZ). 27189511 2016
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.400 Biomarker disease BEFREE Overall, this study demonstrated that miR-195 suppressed PCa cell metastasis by downregulating FGF2. miR-195 restoration may be considered as a new therapeutic method to treat metastatic PCa. 26650737 2015
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.400 Biomarker disease BEFREE We demonstrated that bFGF promoted EMT and motility of human prostate cancer PC-3 cells. 25088797 2014
CUI: C0017638
Disease: Glioma
Glioma
0.400 Biomarker disease BEFREE Based on our previous successful construction of a lentivirus-mediated alphastatin (an endogenous angiogenesis inhibitor) gene transfer system and our findings that alphastatin exhibited potent inhibitory effects on the migration and differentiation of human umbilical vein endothelial cell lines (HUVECs) induced by vascular endothelial growth factor (VEGF) or basic fibroblast growth factor (bFGF) in vitro, here, we investigated the effect of using lentiviral vectors to overexpress alphastatin in human glioma cells to show whether sustained long-term expression of alphastatin diminishes tumor growth in a xenograft glioma model. 23242200 2013
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.400 Biomarker disease BEFREE FGF-2 disrupts mitotic stability in prostate cancer through the intracellular trafficking protein CEP57. 23243019 2013
CUI: C0017638
Disease: Glioma
Glioma
0.400 AlteredExpression disease BEFREE An optimal siRNA sequence specific for bFGF mRNA was cloned into an adenoviral vector and transfected into three glioma cell lines: U251, A172, and LN229. 20221717 2011
CUI: C0017638
Disease: Glioma
Glioma
0.400 Biomarker disease BEFREE Our results offer a potential mechanism for using Ad-bFGF-siRNA as a gene therapy for glioma. 21906308 2011
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.400 Biomarker disease BEFREE In human prostate cancer DU145 cells, FSK (1 μM) and FGF2 (10 ng/ml) increased BSP and Runx2 mRNA and protein levels at 3 and 12h, respectively. 20965237 2011
CUI: C0017638
Disease: Glioma
Glioma
0.400 Biomarker disease BEFREE In this study, a bFGF-targeted siRNA was delivered to the glioma cell line, U251, using adenovirus (Ad-bFGF-siRNA) and the expression of connexin 43 and its phosphorylation state were evaluated. 20074329 2010
CUI: C0017638
Disease: Glioma
Glioma
0.400 Biomarker disease BEFREE A glioblastoma stem cell (GSC) line, GSC11, grows as neurospheres in serum-free media supplemented with EGF (epidermal growth factor) and bFGF (basic fibroblast growth factor), and, if implanted in nude mice brains, will recapitulate high-grade glial tumors. 20199106 2010
CUI: C0017638
Disease: Glioma
Glioma
0.400 AlteredExpression disease LHGDN We present a positive correlation between the autocrine expression of YY1 and TGF-beta 1, IGF-1 and FGF-2, known to be involved in the progression of gliomas and meningiomas. 19235591 2009
CUI: C0017638
Disease: Glioma
Glioma
0.400 Biomarker disease BEFREE We present a positive correlation between the autocrine expression of YY1 and TGF-beta 1, IGF-1 and FGF-2, known to be involved in the progression of gliomas and meningiomas. 19235591 2009
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.400 AlteredExpression disease BEFREE Caveolin-1 (cav-1) and the cancer-promoting growth factors vascular endothelial growth factor (VEGF), transforming growth factor beta1 (TGF-beta1), and fibroblast growth factor 2 (FGF2) are often found to be upregulated in advanced prostate cancer and other malignancies. 19903767 2009
CUI: C0017638
Disease: Glioma
Glioma
0.400 Biomarker disease BEFREE In particular, we demonstrate that HMW FGF-2 has unique features in inhibiting glioma cell proliferation. 18930044 2008
CUI: C0017638
Disease: Glioma
Glioma
0.400 Biomarker disease BEFREE The G-rich promoter and G-rich coding sequence of basic fibroblast growth factor are the targets of thalidomide in glioma. 18687660 2008
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.400 Biomarker disease BEFREE Fibroblast growth factor-2 mediates transforming growth factor-beta action in prostate cancer reactive stroma. 17637743 2008
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.400 Biomarker disease BEFREE These data indicate that endogenously synthesized fibrinogen promotes the growth of lung and prostate cancer cells through interaction with FGF-2. 17949478 2008
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.400 Biomarker disease BEFREE Fibroblast growth factor 2 (FGF2) is a pleiotropic growth factor that has been implicated in prostate cancer formation and progression. 16940294 2006