|
Chronic myeloproliferative disorder
|
0.100 |
Biomarker
|
disease |
BEFREE |
By analogy with these, we propose that the RAMP-FGFR1 fusion product will contribute to progression of this myeloproliferative disorder by constitutive activation of tyrosine kinase function.
|
9499416 |
1998 |
|
Chronic myeloproliferative disorder
|
0.100 |
Biomarker
|
disease |
BEFREE |
Fibroblast growth factor receptor 1 is fused to FIM in stem-cell myeloproliferative disorder with t(8;13).
|
9576949 |
1998 |
|
Chronic myeloproliferative disorder
|
0.100 |
Biomarker
|
disease |
BEFREE |
Characterization of FIM-FGFR1, the fusion product of the myeloproliferative disorder-associated t(8;13) translocation.
|
10480903 |
1999 |
|
Chronic myeloproliferative disorder
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
FGFR1 is fused to the centrosome-associated protein CEP110 in the 8p12 stem cell myeloproliferative disorder with t(8;9)(p12;q33).
|
10688839 |
2000 |
|
Chronic myeloproliferative disorder
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The 8p12 myeloproliferative disorder. t(8;19)(p12;q13.3): a novel translocation involving the FGFR1 gene.
|
11122115 |
2000 |
|
Chronic myeloproliferative disorder
|
0.100 |
Biomarker
|
disease |
BEFREE |
Further FISH indicated a breakpoint within fibroblast growth factor receptor 1 (FGFR1), the receptor tyrosine kinase that is known to be disrupted in a distinctive myeloproliferative disorder, most commonly by fusion to ZNF198.
|
11739186 |
2001 |
|
Chronic myeloproliferative disorder
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Fusion of the BCR and the fibroblast growth factor receptor-1 (FGFR1) genes as a result of t(8;22)(p11;q11) in a myeloproliferative disorder: the first fusion gene involving BCR but not ABL.
|
11746971 |
2001 |
|
Chronic myeloproliferative disorder
|
0.100 |
Biomarker
|
disease |
BEFREE |
Disruption of FGFR1 is associated with a disease entity known as the 8p11 myeloproliferative syndrome (EMS)/stem cell leukemia-lymphoma syndrome, a chronic myeloproliferative disorder that frequently presents with eosinophilia and associated T-cell lymphoblastic lymphoma.
|
11919391 |
2002 |
|
Chronic myeloproliferative disorder
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Endogenous retroviral sequence is fused to FGFR1 kinase in the 8p12 stem-cell myeloproliferative disorder with t(8;19)(p12;q13.3).
|
12393597 |
2003 |
|
Chronic myeloproliferative disorder
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In this study, we show that expression of FOP-FGFR1 in primary bone marrow cells induced by retroviral transduction generates a MPD in mice.
|
12969958 |
2004 |
|
Chronic myeloproliferative disorder
|
0.100 |
Biomarker
|
disease |
BEFREE |
The t(8;13) translocation, found in a rare and aggressive type of stem cell myeloproliferative disorder, leads to the generation of a fusion protein between the N-terminal gene product of fused in myeloproliferative disorders (FIM)/ZNF198 and the fibroblast growth factor receptor 1 (FGFR1) kinase domain.
|
14672707 |
2004 |
|
Chronic myeloproliferative disorder
|
0.100 |
PosttranslationalModification
|
disease |
BEFREE |
Furthermore, treatment with PKC412 resulted in statistically significant prolongation of survival in the murine model of ZNF198-FGFR1-induced MPD.
|
15448205 |
2004 |
|
Chronic myeloproliferative disorder
|
0.100 |
Biomarker
|
disease |
BEFREE |
Although the FGFR1-MPD is rare, its study provides interesting clues to the understanding of hematopoietic stem cell biology and oncogene activation.
|
15870860 |
2005 |
|
Chronic myeloproliferative disorder
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We describe a case of coexisting BCR-ABL negative myeloproliferative disorder and precursor T-cell lymphoblastic lymphoma associated with t(8;13) involving FGFR1 at 8p11 in a 14-year-old boy who presented with generalized lymphadenopathy and an abdominal mass.
|
16777224 |
2007 |
|
Chronic myeloproliferative disorder
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Combined translocation with ZNF198-FGFR1 gene fusion and deletion of potential tumor suppressors in a myeloproliferative disorder.
|
17321332 |
2007 |
|
Chronic myeloproliferative disorder
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
FIP1L1/PDGFRalpha rearrangements, as well as alterations of PDGFRbeta or FGFR1 gene have been found to be associated with specific types of CMPD.
|
17383090 |
2007 |
|
Chronic myeloproliferative disorder
|
0.100 |
Biomarker
|
disease |
BEFREE |
The 8p11 myeloproliferative syndrome (EMS) is an aggressive, atypical stem cell myeloproliferative disorder associated with chromosome translocations that disrupt and constitutively activate FGFR1 by fusion to diverse partner genes.
|
17698633 |
2007 |
|
Chronic myeloproliferative disorder
|
0.100 |
Biomarker
|
disease |
BEFREE |
The FGFR1-MPD seems refractory to current chemotherapies and is not sensitive to imatinib.
|
18096225 |
2008 |
|
Chronic myeloproliferative disorder
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The revised 2008 WHO classification system featured the following changes: 1) the term "CMPD" was replaced by "myeloproliferative neoplasm (MPN)," 2) mast cell disease was formally included under the category of MPN, and 3) the subcategory of CEL/HES was reorganized into "CEL not otherwise specified (CEL-NOS)" and "myeloid and lymphoid neoplasms with eosinophilia and abnormalities of PDGFRA, PDGFRB, and FGFR1"; CEL-NOS remained a subcategory of "MPN," whereas the latter neoplasms were now assigned a new category of their own.
|
19472396 |
2009 |
|
Chronic myeloproliferative disorder
|
0.100 |
Biomarker
|
disease |
BEFREE |
Important changes include (1) the change of nomenclature of myeloproliferative disorder to myeloproliferative neoplasm emphasizing the clonal nature of these disorders; (2) the classification of mast cell disease as an MPN; (3) the reorganization of the eosinophilic disorders into a molecularly defined category of PDGFRA, PDGFRB and FGFR1-associated myeloid and lymphoid neoplasms with eosinophilia and chronic eosinophilic leukemia, not otherwise specified; and (4) refinement of the diagnostic criteria for PV, ET and PMF incorporating recently described molecular markers, JAK2V617F, JAK2 exon 12 mutations and MPL mutations.
|
20191332 |
2010 |
|
Chronic myeloproliferative disorder
|
0.100 |
Biomarker
|
disease |
BEFREE |
Protein tyrosine kinase abnormalities, including translocations or mutations involving ABL1, JAK2, MPL, KIT, PDGFRA, PDGFRB, and FGFR1, have been used as the basis for classifying myeloproliferative neoplasms (MPN).
|
20626469 |
2010 |
|
Chronic myeloproliferative disorder
|
0.100 |
Biomarker
|
disease |
BEFREE |
The introduction of JAK2 mutation testing has changed dramatically the diagnostic algorithms for myeloproliferative neoplasms (MPNs) but there is still a place for conventional cytogenetic analysis in the initial work-up of MPN cases, particularly as this group of myeloid disorders has been expanded to include chronic eosinophilic leukaemia and myeloid neoplasms with abnormalities of the PDGFRA, PDGFRB, and FGFR1 genes.
|
21431636 |
2011 |
|
Chronic myeloproliferative disorder
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The KG-1a cell line is developed from a human stem cell myeloproliferative neoplasm as the result of intragenic disruption and a chromosomal translocation of the FGFR1 gene and the FGFR1OP2 gene encoding a protein of unknown function called FOP2 (FGFR1 Oncogene Partner 2).
|
21745565 |
2011 |
|
Chronic myeloproliferative disorder
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Here, we report a new translocation at the FGFR1 locus in a patient who carried t(1;8)(q25;p11.2) and presented with myeloproliferative neoplasm-like symptoms.
|
22619110 |
2012 |
|
Chronic myeloproliferative disorder
|
0.100 |
Biomarker
|
disease |
BEFREE |
Localization of the FOP-FGFR1 fusion kinase to centriolar satellites may be relevant to myeloproliferative neoplasm disease progression.
|
23554904 |
2013 |