FGFR1, fibroblast growth factor receptor 1, 2260

N. diseases: 816; N. variants: 119
Disease: Depressive disorder ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.620 GeneticVariation disease BEFREE Disturbances in the 5-HT1A⁻FGFR1 heteroreceptor complexes in the raphe-hippocampal 5-HT system were found in a genetic rat model of depression (Flinders sensitive line (FSL) rats). 29865267 2018
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.620 GeneticVariation disease BEFREE We studied in the current work the disturbances in the FGFR1-5-HT1A heterocomplexes in a genetic rat model of depression, the Flinders sensitive line (FSL) rats of Sprague-Dawley (SD) origin, by means of neurochemical, neurophysiological and behavioral techniques. 29066953 2017
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.620 Biomarker disease PSYGENET Gene expression analysis of novel genes in the prefrontal cortex of major depressive disorder subjects. 23261523 2013
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.620 Biomarker disease PSYGENET We conclude that a constitutive partial reduction in NCAM proteins results in a behavioural phenotype related to depression without impairment in cognitive functions, also affecting the level of FGFR1 phosphorylation without major alterations in CaMKII and CaMKIV intracellular signalling. 22361116 2012
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.620 Biomarker disease PSYGENET Molecular genetics and developmental studies have identified 21 genes in this region (ADRA1A, ARHGEF10, CHRNA2, CHRNA6, CHRNB3, DKK4, DPYSL2, EGR3, FGF17, FGF20, FGFR1, FZD3, LDL, NAT2, NEF3, NRG1, PCM1, PLAT, PPP3CC, SFRP1 and VMAT1/SLC18A1) that are most likely to contribute to neuropsychiatric disorders (schizophrenia, autism, bipolar disorder and depression), neurodegenerative disorders (Parkinson's and Alzheimer's disease) and cancer. 19204725 2009
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.620 Biomarker disease CTD_human FGFR1 mRNA expression was higher in depression than in the other groups in CA1, CA4 and DG. 16861106 2006
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.620 Biomarker disease PSYGENET Cooperation between ectopic FGFR1 and depression of FGFR2 in induction of prostatic intraepithelial neoplasia in the mouse prostate. 14695195 2003
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.620 Biomarker disease HPO