FGFR1, fibroblast growth factor receptor 1, 2260

N. diseases: 816; N. variants: 119
Disease: Glioblastoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0017636
Disease: Glioblastoma
Glioblastoma 		0.200 Biomarker disease BEFREE Tie2-FGFR1 Interaction Induces Adaptive PI3K Inhibitor Resistance by Upregulating Aurora A/PLK1/CDK1 Signaling in Glioblastoma. 31416846 2019
CUI: C0017636
Disease: Glioblastoma
Glioblastoma 		0.200 Biomarker disease BEFREE These findings reveal a new signaling axis for GSC maintenance and highlight ADAMDEC1 and FGFR1 as potential therapeutic targets in GBM. 31434712 2019
CUI: C0017636
Disease: Glioblastoma
Glioblastoma 		0.200 Biomarker disease BEFREE Alpha6-Integrin Regulates FGFR1 Expression through the ZEB1/YAP1 Transcription Complex in Glioblastoma Stem Cells Resulting in Enhanced Proliferation and Stemness. 30909436 2019
CUI: C0017636
Disease: Glioblastoma
Glioblastoma 		0.200 Biomarker disease BEFREE Silencing FGFR1 or FOXM1 downregulated genes involved in mesenchymal transition such as GLI2, TWIST1, and ZEB1 in glioblastoma stem-like cells. 30167084 2018
CUI: C0017636
Disease: Glioblastoma
Glioblastoma 		0.200 Biomarker disease BEFREE Taken together, our results offer a preclinical proof of concept that FGFR1 targeting can degrade radioresistance in glioblastoma, a widespread problem in this tumor, prompting clinical investigations of the use of FGFR1 inhibitors for radiosensitization. 26896280 2016
CUI: C0017636
Disease: Glioblastoma
Glioblastoma 		0.200 GeneticVariation disease CLINVAR Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity. 26619011 2016
CUI: C0017636
Disease: Glioblastoma
Glioblastoma 		0.200 Biomarker disease BEFREE FGFR1 and FGFR3 genes are fused to neighboring TACC1 and TACC3 genes, respectively, due to interstitial deletions in glioblastoma multiforme. 23696246 2014
CUI: C0017636
Disease: Glioblastoma
Glioblastoma 		0.200 AlteredExpression disease BEFREE Down-regulation of FGFR1 and, consequently, inactivation of its signaling pathways represent novel treatment strategies for glioblastoma. 22903848 2013
CUI: C0017636
Disease: Glioblastoma
Glioblastoma 		0.200 Biomarker disease BEFREE Blockade of FGFR1-mediated signals by pharmacological FGFR inhibitors or a dominant-negative FGFR1 IIIc protein inhibited GBM cell proliferation and/or induced apoptotic cell death. 18362893 2008
CUI: C0017636
Disease: Glioblastoma
Glioblastoma 		0.200 Biomarker disease LHGDN EphA4 promotes cell proliferation and migration through a novel EphA4-FGFR1 signaling pathway in the human glioma U251 cell line. 18790757 2008
CUI: C0017636
Disease: Glioblastoma
Glioblastoma 		0.200 GeneticVariation disease LHGDN Sequence survey of receptor tyrosine kinases reveals mutations in glioblastomas. 16186508 2005
CUI: C0017636
Disease: Glioblastoma
Glioblastoma 		0.200 GeneticVariation disease BEFREE The correction of FGFR1 gene splicing to >90% alpha-exon inclusion in glioblastoma cells had no discernable effect on cell growth in culture, but was associated with an increase in unstimulated caspase-3 and -7 activity. 15333583 2004
CUI: C0017636
Disease: Glioblastoma
Glioblastoma 		0.200 Biomarker disease BEFREE Fibroblast growth factor receptor-1 alpha-exon exclusion and polypyrimidine tract-binding protein in glioblastoma multiforme tumors. 10728679 2000
CUI: C0017636
Disease: Glioblastoma
Glioblastoma 		0.200 AlteredExpression disease BEFREE Glioblastoma (the most malignant form of astrocytoma) cell lines, which exhibit the same pattern of FGFR gene expression as glioblastoma biopsies, were used to evaluate the contribution of FGFR1 expression to glioblastoma cell growth. 10498824 1999
CUI: C0017636
Disease: Glioblastoma
Glioblastoma 		0.200 Biomarker disease BEFREE Redundant intronic repressors function to inhibit fibroblast growth factor receptor-1 alpha-exon recognition in glioblastoma cells. 10488155 1999
CUI: C0017636
Disease: Glioblastoma
Glioblastoma 		0.200 AlteredExpression disease BEFREE Glioblastomas also expressed an alternatively spliced form of FGFR1 containing two immunoglobulin-like disulfide loops (FGFR1 beta), whereas normal human adult and fetal brain expressed a form of the receptor containing three immunoglobulin-like disulfide loops (FGFR1 alpha). 7964981 1994
CUI: C0017636
Disease: Glioblastoma
Glioblastoma 		0.200 AlteredExpression disease BEFREE Examination of the FGFR1 gene by Southern blot analysis indicated that overexpression of FGFR1 mRNA in glioblastomas did not result from gene amplification. 8168112 1994