FOXO3, forkhead box O3, 2309

N. diseases: 381; N. variants: 30
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0028754
Disease: Obesity
Obesity
0.520 Biomarker disease BEFREE The current study is the first to provide evidence that Met could ameliorate muscle atrophy in high-fat diet induced obesity and this effect may be in part due to regulation of PGC-1α-FoxO3 pathway. 30320911 2019
CUI: C0028754
Disease: Obesity
Obesity
0.520 Biomarker disease BEFREE Taken together, these data show that oxyresveratrol increases energy expenditure through the induction of thermogenic genes in adipose tissue and further implicates oxyresveratrol as an ingredient and Foxo3a as a molecular target for the development of functional foods in obesity and metabolic diseases. 30577593 2018
CUI: C0028754
Disease: Obesity
Obesity
0.520 Biomarker disease CTD_human Obese mouse ovaries had decreased Irs1, Foxo3a, Cyp2e1, MiR-103, and MiR-21 but increased Kitlg, Akt1, and miR-184 levels relative to lean littermates. 23954404 2013
CUI: C0028754
Disease: Obesity
Obesity
0.520 Biomarker disease RGD High-fat diet-induced juvenile obesity leads to cardiomyocyte dysfunction and upregulation of Foxo3a transcription factor independent of lipotoxicity and apoptosis. 16467659 2006