|
Obesity
|
0.520 |
Biomarker
|
disease |
BEFREE |
The current study is the first to provide evidence that Met could ameliorate muscle atrophy in high-fat diet induced obesity and this effect may be in part due to regulation of PGC-1α-FoxO3 pathway.
|
30320911 |
2019 |
|
Obesity
|
0.520 |
Biomarker
|
disease |
BEFREE |
Taken together, these data show that oxyresveratrol increases energy expenditure through the induction of thermogenic genes in adipose tissue and further implicates oxyresveratrol as an ingredient and Foxo3a as a molecular target for the development of functional foods in obesity and metabolic diseases.
|
30577593 |
2018 |
|
Obesity
|
0.520 |
Biomarker
|
disease |
CTD_human |
Obese mouse ovaries had decreased Irs1, Foxo3a, Cyp2e1, MiR-103, and MiR-21 but increased Kitlg, Akt1, and miR-184 levels relative to lean littermates.
|
23954404 |
2013 |
|
Obesity
|
0.520 |
Biomarker
|
disease |
RGD |
High-fat diet-induced juvenile obesity leads to cardiomyocyte dysfunction and upregulation of Foxo3a transcription factor independent of lipotoxicity and apoptosis.
|
16467659 |
2006 |
|
Diabetes Mellitus, Experimental
|
0.500 |
Biomarker
|
disease |
CTD_human |
Resveratrol prevents renal lipotoxicity and inhibits mesangial cell glucotoxicity in a manner dependent on the AMPK-SIRT1-PGC1α axis in db/db mice.
|
23090186 |
2013 |
|
Diabetes Mellitus, Experimental
|
0.500 |
Biomarker
|
disease |
CTD_human |
Resveratrol, an activator of SIRT1, restores erectile function in streptozotocin-induced diabetic rats.
|
23792339 |
2013 |
|
Diabetes Mellitus, Experimental
|
0.500 |
Biomarker
|
disease |
RGD |
Role of the Akt/FoxO3a pathway in TGF-beta1-mediated mesangial cell dysfunction: a novel mechanism related to diabetic kidney disease.
|
17082237 |
2006 |
|
Diabetes Mellitus, Experimental
|
0.500 |
Biomarker
|
disease |
RGD |
Nutritional and hormonal factors control the gene expression of FoxOs, the mammalian homologues of DAF-16.
|
12683947 |
2003 |
|
Non-Small Cell Lung Carcinoma
|
0.370 |
Biomarker
|
disease |
BEFREE |
Circ_0002483 was demonstrated to inhibit NSCLC progression in vitro and in vivo and enhanced the sensitivity of NSCLC cells to Taxol by sponging miR-182-5p to release the inhibition on GRB2, FOXO1, and FOXO3 mRNAs.
|
31844042 |
2019 |
|
Non-Small Cell Lung Carcinoma
|
0.370 |
Biomarker
|
disease |
BEFREE |
We observed that the expression of EPS8 inversely correlated with FoxO3a in NSCLC cell lines and NSCLC patients.
|
30738830 |
2019 |
|
Non-Small Cell Lung Carcinoma
|
0.370 |
AlteredExpression
|
disease |
BEFREE |
By performing Taq‑man based RT‑qPCR, it was identified that circRNA‑FOXO3 was downregulated in NSCLC tissues and cell lines.
|
29620202 |
2018 |
|
Non-Small Cell Lung Carcinoma
|
0.370 |
AlteredExpression
|
disease |
BEFREE |
We have showed that BBR inhibited growth of non-small cell lung cancer (NSCLC) cells through mitogen-activated protein kinase (MAPK)-mediated increase in forkhead box O3a (FOXO3a).
|
28840963 |
2018 |
|
Non-Small Cell Lung Carcinoma
|
0.370 |
AlteredExpression
|
disease |
BEFREE |
We previously showed that FZKA decoction inhibited proliferation of non-small cell lung cancer (NSCLC) cells through activation of AMP-activated protein kinase alpha (AMPK<i>α</i>) signaling pathway, followed by inducing insulin-like growth factor (IGF) binding protein 1 (IGFBP1) and forkhead homeobox type O3a (FOXO3a) proteins, and enhanced the inhibition effect of gefitinib in lung cancer cell growth via inactivating PI3-K/Akt-mediated suppressing of cell surface-associated mucin-1 (MUC1) expression.
|
30046347 |
2018 |
|
Non-Small Cell Lung Carcinoma
|
0.370 |
Biomarker
|
disease |
BEFREE |
This study reveals a novel mechanism for regulating FOXO3a and RUNX3 signaling axis in response to baicalein and suggests a new strategy for NSCLC associated targeted therapy.
|
25948105 |
2015 |
|
Non-Small Cell Lung Carcinoma
|
0.370 |
Biomarker
|
disease |
BEFREE |
Expression of microRNA-96 and its potential functions by targeting FOXO3 in non-small cell lung cancer.
|
25286764 |
2015 |
|
Non-Small Cell Lung Carcinoma
|
0.370 |
Biomarker
|
disease |
CTD_human |
FOXO3a elicits a pro-apoptotic transcription program and cellular response to human lung carcinogen nicotine-derived nitrosaminoketone (NNK).
|
19380174 |
2010 |
|
Chronic Obstructive Airway Disease
|
0.350 |
AlteredExpression
|
disease |
BEFREE |
In PBECs, the constitutive FoxO3 expression was lower in patients with COPD than in controls.
|
29411515 |
2018 |
|
Chronic Obstructive Airway Disease
|
0.350 |
Biomarker
|
disease |
BEFREE |
UPS signaling was unaltered, whereas indices of UPS regulation (eg, FOXO1 protein; p-FOXO3/FOXO3), autophagy signaling (eg, LC3BII/I; p-ULK1[Ser757]/ULK1), and protein synthesis signaling (eg, AKT1; p-GSK3B/GSK3B; p-4E-BP1/4E-BP1) were increased in COPD.
|
28578881 |
2017 |
|
Chronic Obstructive Airway Disease
|
0.350 |
Biomarker
|
disease |
BEFREE |
LncRNA‑mediated SIRT1/FoxO3a and SIRT1/p53 signaling pathways regulate type II alveolar epithelial cell senescence in patients with chronic obstructive pulmonary disease.
|
28339038 |
2017 |
|
Adenocarcinoma of lung (disorder)
|
0.350 |
AlteredExpression
|
disease |
BEFREE |
Cordycepin induces apoptosis by caveolin-1-mediated JNK regulation of Foxo3a in human lung adenocarcinoma.
|
28099944 |
2017 |
|
Adenocarcinoma of lung (disorder)
|
0.350 |
Biomarker
|
disease |
BEFREE |
p38α MAPK-mediated induction and interaction of FOXO3a and p53 contribute to the inhibited-growth and induced-apoptosis of human lung adenocarcinoma cells by berberine.
|
24766860 |
2014 |
|
Adenocarcinoma of lung (disorder)
|
0.350 |
AlteredExpression
|
disease |
BEFREE |
On the other hand, FOXO3A activity is known to be downregulated in various cancers, and the gene was recently identified as a novel deletion hotspot in human lung adenocarcinoma.
|
24014251 |
2014 |
|
Chronic Obstructive Airway Disease
|
0.350 |
Biomarker
|
disease |
CTD_human |
Decreased FoxO3A in COPD cells was associated with increased phosphorylation of EGFR, Akt and FoxO3A and treatment with quercetin, LY294002 or erlotinib increased nuclear FoxO3A and decreased IL-8 and phosphorylation of Akt, EGFR and FoxO3A, Compared with control, elastase/LPS-exposed mice showed decreased nuclear FoxO3A, increased chemokines and phosphorylation of EGFR and Akt.
|
23099361 |
2013 |
|
Chronic Obstructive Airway Disease
|
0.350 |
AlteredExpression
|
disease |
BEFREE |
Similar protective effects of Vam3, reducing autophagy and restoring the levels of Sirt1 and FoxO3a, were observed in the COPD animal model.
|
22705731 |
2012 |
|
Chronic Obstructive Airway Disease
|
0.350 |
Biomarker
|
disease |
BEFREE |
These results suggest that FoxO3 plays a pivotal role in regulation of lung inflammatory response and antioxidant genes, and deficiency of FoxO3 results in development of chronic obstructive pulmonary disease/emphysema.
|
21690325 |
2011 |