|
Neuroblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Hypermethylation of the miR-137 promoter and negative regulation of miR-137 by CAR contribute in part to reduced miR-137 expression and increased CAR and MDR1 expression in doxorubicin-resistant neuroblastoma cells.
|
23934188 |
2014 |
|
Neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Study of the mechanisms underlying the reversal of multidrug resistance of human neuroblastoma multidrug-resistant cell line SK-N-SH/MDR1 by low-intensity pulsed ultrasound.
|
23483136 |
2013 |
|
Neuroblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
To this end, we used an inducible siRNA (small interfering RNA) expression system to silence the expression of MRP1 and MDR1 in human neuroblastoma SH-SY5Y cells.
|
18713069 |
2009 |
|
Neuroblastoma
|
0.100 |
PosttranslationalModification
|
disease |
BEFREE |
Data from present study suggest that transcriptional inactivation of MDR1 gene due to increased MDR1 promoter methylation may be a contributing factor in pathogenesis and progression of neuroblastoma tumors, and may be used in designing an effective treatment therapy to neuroblastoma patients.
|
17387584 |
2007 |
|
Neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The results show that BS-RNase selectively kills NB cells by inducing apoptosis and that this agent is active against mdr-1 expressing cells both in vitro and in vivo.
|
10536185 |
1999 |
|
Neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
However, the clinical significance of the expression of the multidrug resistance gene (MDR1) product P-gp in neuroblastoma (NB) is still a matter of debate.
|
9317175 |
1997 |
|
Neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
These findings suggest a clinical role for the MDR1 gene in specific subgroups of primary neuroblastoma.
|
9516848 |
1997 |
|
Neuroblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Expression of mdr1/P-glycoprotein and p110 in neuroblastoma.
|
7891222 |
1995 |
|
Neuroblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Decreased expression of the N-myc oncogene in neuroblastoma cell lines SH-SY5Y and BE(2)-C, following treatment with retinoic acid, was paralleled by down-regulation of MRP gene expression, contrasting with increased expression of the MDR1 gene.
|
7923112 |
1994 |
|
Neuroblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
This study offers compelling evidence that (a) IGR-N-91 is a human neuroblastoma xenograft model able to induce metastasis in nude mice, (b) an increase in MYCN and MDR1 transcripts levels is associated with the metastatic process, and (c) IGR-N-91 provides a biological tool for the study of gene activations during tumor dissemination in neuroblastoma.
|
8174136 |
1994 |
|
Neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Expression of N-myc, c-myc, and MDR-1 proteins in newly established neuroblastoma cell lines: a study by immunofluorescence staining and flow cytometry.
|
1374683 |
1992 |
|
Neuroblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Because expression of mdr-1 is increased in neuroblastoma cell lines by differentiating agents, the authors hypothesized a similar correlation with differentiation in vivo in neuroblastomas.
|
1678252 |
1991 |
|
Neuroblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
MDR1 mRNA transcription may occur spontaneously after onset, suggesting that certain NB tumors could be resistant to antineoplastic drugs at onset.
|
1974410 |
1990 |
|
Neuroblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Many of the neuroblastoma samples were also evaluated for N-myc amplification but there was no correlation between N-myc copy number and the level of MDR1 mRNA expression.
|
2295903 |
1990 |
|
Neuroblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The role, if any, of increased expression of mdr-1 in the acquisition of multidrug resistance in neuroblastoma remains unclear.
|
2185879 |
1990 |
|
Neuroblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
For the 26 treated neuroblastomas, the number of nonresponsive tumors was found to be significantly higher among those with high levels of MDR1 mRNA.
|
2778826 |
1989 |
|
Neuroblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
MDR1 RNA levels were occasionally elevated in other untreated cancers, including neuroblastoma, acute lymphocytic leukemia (ALL) in adults, acute nonlymphocytic leukemia (ANLL) in adults, and indolent non-Hodgkin's lymphoma.
|
2562856 |
1989 |
|
Neuroblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
An increase in the level of mdr1 mRNA was observed after retinoic acid treatment of four neuroblastoma cell lines, including the SK-N-SH cell line.
|
2573830 |
1989 |