Malignant neoplasm of breast
|
0.350 |
Biomarker
|
disease |
BEFREE |
However, the precise role of JMJD6 in breast cancer development remains unclear.
|
30185813 |
2019 |
Breast Carcinoma
|
0.350 |
Biomarker
|
disease |
BEFREE |
However, the precise role of JMJD6 in breast cancer development remains unclear.
|
30185813 |
2019 |
Malignant neoplasm of breast
|
0.350 |
AlteredExpression
|
disease |
BEFREE |
We show that overexpression of JMJD6 increased HOTAIR expression and JMJD6 siRNAs suppressed it in ER+ MCF-7, triple negative MDA-MB-231 and non-breast cancer HEK 293 cells.
|
29229759 |
2018 |
Malignant neoplasm of breast
|
0.350 |
AlteredExpression
|
disease |
BEFREE |
Consistent with its role in transcriptional activation, JMJD6 is required for estrogen/ERα-induced breast cancer cell growth and tumorigenesis.
|
29628309 |
2018 |
Malignant neoplasm of breast
|
0.350 |
Biomarker
|
disease |
CTD_human |
Ras-Induced miR-146a and 193a Target Jmjd6 to Regulate Melanoma Progression.
|
30619488 |
2018 |
Breast Carcinoma
|
0.350 |
Biomarker
|
disease |
CTD_human |
Ras-Induced miR-146a and 193a Target Jmjd6 to Regulate Melanoma Progression.
|
30619488 |
2018 |
Breast Carcinoma
|
0.350 |
AlteredExpression
|
disease |
BEFREE |
Consistent with its role in transcriptional activation, JMJD6 is required for estrogen/ERα-induced breast cancer cell growth and tumorigenesis.
|
29628309 |
2018 |
Breast Carcinoma
|
0.350 |
AlteredExpression
|
disease |
BEFREE |
We show that overexpression of JMJD6 increased HOTAIR expression and JMJD6 siRNAs suppressed it in ER+ MCF-7, triple negative MDA-MB-231 and non-breast cancer HEK 293 cells.
|
29229759 |
2018 |
Malignant neoplasm of breast
|
0.350 |
AlteredExpression
|
disease |
BEFREE |
Although JMJD6 displays anti-tumoral properties in cell lines, its expression in breast tumours may be a marker of poor prognosis, suggesting that its function could be altered in breast cancer.
|
25951181 |
2015 |
Breast Carcinoma
|
0.350 |
AlteredExpression
|
disease |
BEFREE |
Although JMJD6 displays anti-tumoral properties in cell lines, its expression in breast tumours may be a marker of poor prognosis, suggesting that its function could be altered in breast cancer.
|
25951181 |
2015 |
Malignant neoplasm of breast
|
0.350 |
Biomarker
|
disease |
BEFREE |
Immunohistochemistry, siRNA-mediated silencing, and forced overexpression of JMJD6 in cell-based assays elucidated molecular mechanisms of JMJD6 action in breast cancer progression and shed light on the clinical breast cancer subtypes relevant to JMJD6 action.
|
22621393 |
2012 |
Breast Carcinoma
|
0.350 |
Biomarker
|
disease |
BEFREE |
Immunohistochemistry, siRNA-mediated silencing, and forced overexpression of JMJD6 in cell-based assays elucidated molecular mechanisms of JMJD6 action in breast cancer progression and shed light on the clinical breast cancer subtypes relevant to JMJD6 action.
|
22621393 |
2012 |
melanoma
|
0.320 |
Biomarker
|
disease |
BEFREE |
Indeed, triple transgenic fish engineered to express a microRNA-resistant Jmjd6 from the onset of melanoma have increased tumor burden, higher infiltration of leukocytes and shorter melanoma-free survival.
|
30619488 |
2018 |
melanoma
|
0.320 |
Biomarker
|
disease |
CTD_human |
Increased <i>JMJD6</i> expression is found in several human cancers, including melanoma, suggesting that the up-regulation of Jmjd6 is a critical event in tumor progression.
|
30619488 |
2018 |
Mammary Neoplasms
|
0.320 |
Biomarker
|
group |
CTD_human |
Ras-Induced miR-146a and 193a Target Jmjd6 to Regulate Melanoma Progression.
|
30619488 |
2018 |
Mammary Neoplasms
|
0.320 |
AlteredExpression
|
group |
BEFREE |
We propose that high JMJD6 expression may achieve higher levels of HOTAIR in breast tumors.
|
29229759 |
2018 |
melanoma
|
0.320 |
AlteredExpression
|
disease |
BEFREE |
We found that high expression of JMJD6 is closely correlated with advanced clinicopathologic stage, aggressiveness, and poor prognosis of melanoma.
|
29187213 |
2017 |
Mammary Neoplasms
|
0.320 |
AlteredExpression
|
group |
BEFREE |
The analysis of JMJD6 expression in a cohort of breast tumour samples indicates that JMJD6 was highly expressed in aggressive breast tumours.
|
25951181 |
2015 |
Uveal melanoma
|
0.310 |
Biomarker
|
disease |
BEFREE |
KRas-ERK signalling promotes the onset and maintenance of uveal melanoma through regulating JMJD6-mediated H2A.X phosphorylation at tyrosine 39.
|
31736361 |
2019 |
ovarian neoplasm
|
0.310 |
AlteredExpression
|
disease |
BEFREE |
In the present study, we found that the high expression of JMJD6 in ovarian cancer was correlated with poor prognosis in ovarian cancer.
|
31637004 |
2019 |
Malignant neoplasm of ovary
|
0.310 |
AlteredExpression
|
disease |
BEFREE |
In the present study, we found that the high expression of JMJD6 in ovarian cancer was correlated with poor prognosis in ovarian cancer.
|
31637004 |
2019 |
Uveal melanoma
|
0.310 |
Biomarker
|
disease |
CTD_human |
Ras-Induced miR-146a and 193a Target Jmjd6 to Regulate Melanoma Progression.
|
30619488 |
2018 |
ovarian neoplasm
|
0.310 |
Biomarker
|
disease |
CTD_human |
Ras-Induced miR-146a and 193a Target Jmjd6 to Regulate Melanoma Progression.
|
30619488 |
2018 |
Malignant neoplasm of ovary
|
0.310 |
Biomarker
|
disease |
CTD_human |
Ras-Induced miR-146a and 193a Target Jmjd6 to Regulate Melanoma Progression.
|
30619488 |
2018 |
Mesothelioma
|
0.300 |
Biomarker
|
disease |
CTD_human |
Ras-Induced miR-146a and 193a Target Jmjd6 to Regulate Melanoma Progression.
|
30619488 |
2018 |