Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.350 Biomarker disease BEFREE However, the precise role of JMJD6 in breast cancer development remains unclear. 30185813 2019
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.350 Biomarker disease BEFREE However, the precise role of JMJD6 in breast cancer development remains unclear. 30185813 2019
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.350 AlteredExpression disease BEFREE We show that overexpression of JMJD6 increased HOTAIR expression and JMJD6 siRNAs suppressed it in ER+ MCF-7, triple negative MDA-MB-231 and non-breast cancer HEK 293 cells. 29229759 2018
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.350 AlteredExpression disease BEFREE Consistent with its role in transcriptional activation, JMJD6 is required for estrogen/ERα-induced breast cancer cell growth and tumorigenesis. 29628309 2018
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.350 Biomarker disease CTD_human Ras-Induced miR-146a and 193a Target Jmjd6 to Regulate Melanoma Progression. 30619488 2018
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.350 Biomarker disease CTD_human Ras-Induced miR-146a and 193a Target Jmjd6 to Regulate Melanoma Progression. 30619488 2018
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.350 AlteredExpression disease BEFREE Consistent with its role in transcriptional activation, JMJD6 is required for estrogen/ERα-induced breast cancer cell growth and tumorigenesis. 29628309 2018
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.350 AlteredExpression disease BEFREE We show that overexpression of JMJD6 increased HOTAIR expression and JMJD6 siRNAs suppressed it in ER+ MCF-7, triple negative MDA-MB-231 and non-breast cancer HEK 293 cells. 29229759 2018
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.350 AlteredExpression disease BEFREE Although JMJD6 displays anti-tumoral properties in cell lines, its expression in breast tumours may be a marker of poor prognosis, suggesting that its function could be altered in breast cancer. 25951181 2015
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.350 AlteredExpression disease BEFREE Although JMJD6 displays anti-tumoral properties in cell lines, its expression in breast tumours may be a marker of poor prognosis, suggesting that its function could be altered in breast cancer. 25951181 2015
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.350 Biomarker disease BEFREE Immunohistochemistry, siRNA-mediated silencing, and forced overexpression of JMJD6 in cell-based assays elucidated molecular mechanisms of JMJD6 action in breast cancer progression and shed light on the clinical breast cancer subtypes relevant to JMJD6 action. 22621393 2012
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.350 Biomarker disease BEFREE Immunohistochemistry, siRNA-mediated silencing, and forced overexpression of JMJD6 in cell-based assays elucidated molecular mechanisms of JMJD6 action in breast cancer progression and shed light on the clinical breast cancer subtypes relevant to JMJD6 action. 22621393 2012
CUI: C0025202
Disease: melanoma
melanoma
0.320 Biomarker disease BEFREE Indeed, triple transgenic fish engineered to express a microRNA-resistant Jmjd6 from the onset of melanoma have increased tumor burden, higher infiltration of leukocytes and shorter melanoma-free survival. 30619488 2018
CUI: C0025202
Disease: melanoma
melanoma
0.320 Biomarker disease CTD_human Increased <i>JMJD6</i> expression is found in several human cancers, including melanoma, suggesting that the up-regulation of Jmjd6 is a critical event in tumor progression. 30619488 2018
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.320 Biomarker group CTD_human Ras-Induced miR-146a and 193a Target Jmjd6 to Regulate Melanoma Progression. 30619488 2018
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.320 AlteredExpression group BEFREE We propose that high JMJD6 expression may achieve higher levels of HOTAIR in breast tumors. 29229759 2018
CUI: C0025202
Disease: melanoma
melanoma
0.320 AlteredExpression disease BEFREE We found that high expression of JMJD6 is closely correlated with advanced clinicopathologic stage, aggressiveness, and poor prognosis of melanoma. 29187213 2017
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.320 AlteredExpression group BEFREE The analysis of JMJD6 expression in a cohort of breast tumour samples indicates that JMJD6 was highly expressed in aggressive breast tumours. 25951181 2015
CUI: C0220633
Disease: Uveal melanoma
Uveal melanoma
0.310 Biomarker disease BEFREE KRas-ERK signalling promotes the onset and maintenance of uveal melanoma through regulating JMJD6-mediated H2A.X phosphorylation at tyrosine 39. 31736361 2019
CUI: C0919267
Disease: ovarian neoplasm
ovarian neoplasm
0.310 AlteredExpression disease BEFREE In the present study, we found that the high expression of JMJD6 in ovarian cancer was correlated with poor prognosis in ovarian cancer. 31637004 2019
CUI: C1140680
Disease: Malignant neoplasm of ovary
Malignant neoplasm of ovary
0.310 AlteredExpression disease BEFREE In the present study, we found that the high expression of JMJD6 in ovarian cancer was correlated with poor prognosis in ovarian cancer. 31637004 2019
CUI: C0220633
Disease: Uveal melanoma
Uveal melanoma
0.310 Biomarker disease CTD_human Ras-Induced miR-146a and 193a Target Jmjd6 to Regulate Melanoma Progression. 30619488 2018
CUI: C0919267
Disease: ovarian neoplasm
ovarian neoplasm
0.310 Biomarker disease CTD_human Ras-Induced miR-146a and 193a Target Jmjd6 to Regulate Melanoma Progression. 30619488 2018
CUI: C1140680
Disease: Malignant neoplasm of ovary
Malignant neoplasm of ovary
0.310 Biomarker disease CTD_human Ras-Induced miR-146a and 193a Target Jmjd6 to Regulate Melanoma Progression. 30619488 2018
CUI: C0025500
Disease: Mesothelioma
Mesothelioma
0.300 Biomarker disease CTD_human Ras-Induced miR-146a and 193a Target Jmjd6 to Regulate Melanoma Progression. 30619488 2018