PLCB1, phospholipase C beta 1, 23236

N. diseases: 107; N. variants: 35
Disease: Schizophrenia ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.540 Biomarker disease BEFREE The phosphodiesterase enzyme phospholipase C-β1 has been reported to be reduced in postmortem tissue of schizophrenia patients. 30517689 2019
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.540 GeneticVariation disease BEFREE Deletion of PLCB1 gene in schizophrenia-affected patients. 22507702 2012
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.540 AlteredExpression disease BEFREE Our data confirm that phospholipase C beta 1 transcript levels are decreased in the dorsolateral prefrontal cortex from subjects with schizophrenia. 21091263 2011
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.540 Biomarker disease BEFREE The most significant SNPs resided in ROR1 and PLCB1, genes known to be involved in bipolar disorder and schizophrenia, respectively. 21494683 2011
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.540 Biomarker disease MGD Phospholipase C-beta1 knockout mice exhibit endophenotypes modeling schizophrenia which are rescued by environmental enrichment and clozapine administration. 17667964 2008
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.540 Biomarker disease CTD_human Phospholipase C-beta1 knockout mice exhibit endophenotypes modeling schizophrenia which are rescued by environmental enrichment and clozapine administration. 17667964 2008