Autoimmune Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
We previously reported that Clec16a deficiency modified immune reactivity and protected against autoimmunity in the nonobese diabetic (NOD) mouse model for T1D.
|
31435002 |
2020 |
Autoimmune Diseases
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Taken together, loss of function variants in CLEC16A that are associated with decreased CLEC16A expression levels may contribute to inflammation in autoimmunity through disrupted mitophagy.
|
30226884 |
2018 |
Autoimmune Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
These findings suggest that Golgi-associated CLEC16A negatively regulates autophagy via modulation of mTOR activity, and may provide support for a functional link between CLEC16A and autoimmunity.
|
28223137 |
2017 |
Autoimmune Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
The C-type lectin CLEC16A gene is located at 16p13, a susceptibility locus for several autoimmune diseases, including multiple sclerosis.
|
25823473 |
2015 |
Autoimmune Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Genome-wide association studies have revealed that the 16p13 chromosomal region, including CLEC16A, DEXI, CIITA and SOCS1, is associated with susceptibility to autoimmune diseases.
|
23151489 |
2013 |
Autoimmune Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Interestingly, IL-13 and KIAA0350/CLEC16A are susceptibility loci for other autoimmune diseases, supporting the hypothesis of shared pathways of autoimmune susceptibility.
|
22534877 |
2012 |
Autoimmune Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
We fine mapped two primary biliary cirrhosis (PBC) risk loci, CLEC16A (C-type lectin domain family 16 member A)-suppressor of cytokine signaling 1 (SOCS1) and Spi-B protein (SPIB) and sequenced a locus, sialic acid acetylesterase (SIAE), proposed to harbor autoimmunity-associated mutations.
|
22257840 |
2012 |
Autoimmune Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Genomewide association studies have implicated the CLEC16A gene in several autoimmune diseases, including multiple sclerosis (MS) and type 1 diabetes.
|
21179112 |
2011 |
Autoimmune Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
In addition, the DRB1*0901 haplotype and the risk alleles of ERBB3, CLEC16A and CTLA4 were positively associated with the co-occurrence of thyroid autoimmunity.
|
22069271 |
2011 |
Autoimmune Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
All described base polymorphisms are mapping to one LD block of approximately 50 kb within intron 19 of the CLEC16A gene, suggesting a pivotal role of this region for susceptibility of MS and possibly also for other autoimmune diseases.
|
20849399 |
2011 |
Autoimmune Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Variants in CLEC16A, another known autoimmunity locus, showed suggestive evidence for association (rs6498142C>G, P = 1.8 x 10(-7)), and 29 additional loci were identified with P < 5 x 10(-5).
|
20694011 |
2010 |
Autoimmune Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Variants in CLEC16A have conferred susceptibility to autoimmune diseases in genome-wide association studies.
|
19734133 |
2010 |
Autoimmune Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
In addition, other genes also implicated in other autoimmune diseases are linked to Addison's disease, such as cytotoxic T lymphocyte antigen 4 (CTLA-4), protein tyrosine phosphatase non-receptor type 22 (PTPN22), major histocompatibility complex class II transactivator (CIITA), and most recently the C-lectin type gene (CLEC16A).
|
19500759 |
2009 |
Autoimmune Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Several of these risk genes, including CD58 and CLEC16A, are shared by different autoimmune diseases.
|
19834503 |
2009 |
Autoimmune Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Our results seem to discard the influence in CD susceptibility of CIITA and KIAA0350 markers previously associated with other autoimmune diseases.
|
19317741 |
2009 |