Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Diabetes Mellitus, Insulin-Dependent
0.500 Biomarker disease BEFREE We previously reported that Clec16a deficiency modified immune reactivity and protected against autoimmunity in the nonobese diabetic (NOD) mouse model for T1D. 31435002 2020
Diabetes Mellitus, Insulin-Dependent
0.500 GeneticVariation disease BEFREE Clarifying the function of genes at the chromosome 16p13 locus in type 1 diabetes: CLEC16A and DEXI. 31570815 2019
Diabetes Mellitus, Insulin-Dependent
0.500 Biomarker disease BEFREE Chromosome 16p13 is associated with type 1 diabetes and CLEC16A is thought to be the aetiological gene in the region. 30478640 2019
Diabetes Mellitus, Insulin-Dependent
0.500 GeneticVariation disease GWASCAT Fine mapping of type 1 diabetes susceptibility loci and evidence for colocalization of causal variants with lymphoid gene enhancers. 25751624 2015
Diabetes Mellitus, Insulin-Dependent
0.500 GeneticVariation disease BEFREE Our results suggest that the primary mechanism by which genetic variation at CLEC16A contributes to the risk for type 1 diabetes is through reduced expression of DEXI. 25008175 2014
Diabetes Mellitus, Insulin-Dependent
0.500 Biomarker disease BEFREE Clec16a has been identified as a disease susceptibility gene for type 1 diabetes, multiple sclerosis, and adrenal dysfunction, but its function is unknown. 24949970 2014
Diabetes Mellitus, Insulin-Dependent
0.500 Biomarker disease BEFREE Autoantibodies to insulin (IAA), GAD (GADA), insulinoma-associated antigen-2 (IA-2A) and zinc transporter 8 (ZnT8A) were measured in follow-up sera, and genotyping for type 1 diabetes susceptibility genes (HLA-DR/HLA-DQ, INS variable number of tandem repeats [VNTR] and single nucleotide polymorphisms at PTPN22, PTPN2, ERBB3, IL2, SH2B3, CTLA4, IFIH1, KIAA0350 [also known as CLEC16A], CD25, IL18RAP, IL10, COBL) was performed on the DNA samples of children born to a parent with type 1 diabetes and prospectively followed from birth for up to 22 years. 23539116 2013
Diabetes Mellitus, Insulin-Dependent
0.500 GeneticVariation disease BEFREE Our results demonstrated that IL2RA rs11594656 and CLEC16A rs725613 are protective factors of T1D, while NLRP1 rs12150220 and APOA5 -1131T/C are risky factors of T1D and T2D, respectively. 23922971 2013
Diabetes Mellitus, Insulin-Dependent
0.500 GeneticVariation disease BEFREE Children of parents with type 1 diabetes and prospectively followed from birth for the development of islet autoantibodies and diabetes were genotyped for single-nucleotide polymorphisms at 12 type 1 diabetes susceptibility genes (ERBB3, PTPN2, IFIH1, PTPN22, KIAA0350, CD25, CTLA4, SH2B3, IL2, IL18RAP, IL10 and COBL). 22932816 2012
Diabetes Mellitus, Insulin-Dependent
0.500 Biomarker disease BEFREE In reciprocal experiments, a 20 kb fragment of intron 19 of CLEC16A, containing SNPs associated with T1D and MS, as well as with DEXI expression, interacted with the promotor region of DEXI but not with candidate DNA fragments containing other potential causal genes in the region, including CLEC16A. 21989056 2012
Diabetes Mellitus, Insulin-Dependent
0.500 GeneticVariation disease BEFREE The association remains independent of the adjacent T1D risk gene CLEC16A. 23052709 2012
Diabetes Mellitus, Insulin-Dependent
0.500 Biomarker disease BEFREE Non-HLA single nucleotide polymorphisms, INS, IL2RA, ERBB3, CLEC16A and IL7R were associated with T1D. 22069271 2011
Diabetes Mellitus, Insulin-Dependent
0.500 Biomarker disease BEFREE PTPN22 (1p13.2), STAT4 (2q32.2), CTLA4 (2q33.2), HLA (6p21), IL2RA (10p15.1), INS (11p15.5), ERBB3 (12q13.2), SH2B3 (12q24.12), and CLEC16A (16p13.13) were convincingly associated with autoimmune diabetes in adults (P ≤ 0.002), with consistent directions of effect as reported for pediatric type 1 diabetes. 21873553 2011
Diabetes Mellitus, Insulin-Dependent
0.500 GeneticVariation disease BEFREE Genomewide association studies have implicated the CLEC16A gene in several autoimmune diseases, including multiple sclerosis (MS) and type 1 diabetes. 21179112 2011
Diabetes Mellitus, Insulin-Dependent
0.500 GeneticVariation disease GWASDB A genome-wide meta-analysis of six type 1 diabetes cohorts identifies multiple associated loci. 21980299 2011
Diabetes Mellitus, Insulin-Dependent
0.500 GeneticVariation disease GWASCAT Genome-wide association analysis of autoantibody positivity in type 1 diabetes cases. 21829393 2011
Diabetes Mellitus, Insulin-Dependent
0.500 GeneticVariation disease BEFREE CLEC16A, a putative immunoreceptor, was recently established as a susceptibility locus for type I diabetes and multiple sclerosis. 20220768 2010
Diabetes Mellitus, Insulin-Dependent
0.500 GeneticVariation disease BEFREE Associations of CLEC16A polymorphisms with T1D and MS were successfully replicated in a Spanish population. 19221398 2010
Diabetes Mellitus, Insulin-Dependent
0.500 GeneticVariation disease GWASCAT Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes. 19430480 2009
Diabetes Mellitus, Insulin-Dependent
0.500 Biomarker disease BEFREE Taken together these data provide evidence of joint disease association in T1D and MS within CLEC16A and underline a shared disease pathway. 18946483 2009
Diabetes Mellitus, Insulin-Dependent
0.500 GeneticVariation disease GWASDB Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes. 19430480 2009
Diabetes Mellitus, Insulin-Dependent
0.500 GeneticVariation disease BEFREE According to a case-control study and logistic regression adjusting for sex and age, we observed that these SNPs in ERBB3 and CLEC16A were both significantly associated with T1D, with the risk alleles being consistent with those in white populations [adjusting odds ratio by multiplicative model: 1.37 (1.13-1.67), P = 0.001; and 1.28 (1.02-1.60), P = 0.030, respectively]. 18940880 2009
Diabetes Mellitus, Insulin-Dependent
0.500 GeneticVariation disease BEFREE In addition to the support for previously identified loci (PTPN22/1p13; ERBB3/12q13; SH2B3/12q24; CLEC16A/16p13; UBASH3A/21q22), evidence supporting two new and distinct chromosome locations associated with T1D was observed: FHOD3/18q12 (rs2644261, P=5.9 x 10(-4)) and Xp22 (rs5979785, P=6.8 x 10(-3); http://www.T1DBase.org). 19956107 2009
Diabetes Mellitus, Insulin-Dependent
0.500 GeneticVariation disease BEFREE Independent genome-wide association studies highlighted the function of CLEC16A/KIAA0350 polymorphisms modifying the risk to either multiple sclerosis (rs6498169) or type 1 diabetes (rs2903692). 19337309 2009
Diabetes Mellitus, Insulin-Dependent
0.500 GeneticVariation disease BEFREE The intron polymorphism rs725613 in the KIAA0350 gene is associated with susceptibility to T1D, and this association is not race specific. 19178520 2009