Disease: Multiple Sclerosis ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis 		0.500 GeneticVariation disease BEFREE Three SNPs linked to MS clinical severity showed a significant association between the genotype and either the proportion of active lesions (rs2234978/FAS and rs11957313/KCNIP1) or the proportion of mixed active/inactive lesions (rs8056098/CLEC16A). 31228212 2020
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis 		0.500 GeneticVariation disease BEFREE HLA-DRB1*11 and *15, IL7RA rs6897932*C/C, CXCR5 rs523604*A/A, and CLEC16A rs6498169*G/G were found as MS-associated variants common for PPMS and RRMS. 30711878 2019
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis 		0.500 GeneticVariation disease GWASCAT Overexpression of the Cytokine BAFF and Autoimmunity Risk. 28445677 2017
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis 		0.500 GeneticVariation disease BEFREE CLEC16A is in a locus genetically linked to autoimmune diseases including multiple sclerosis, but the function of this gene in the nervous system is unknown. 26987296 2016
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis 		0.500 GeneticVariation disease GWASCAT Novel multiple sclerosis susceptibility loci implicated in epigenetic regulation. 27386562 2016
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis 		0.500 Biomarker disease BEFREE Associations of CLEC16A*G/G and both biallelic combinations in women with MS survived the permutation test. 25903733 2015
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis 		0.500 GeneticVariation disease BEFREE The C-type lectin CLEC16A gene is located at 16p13, a susceptibility locus for several autoimmune diseases, including multiple sclerosis. 25823473 2015
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis 		0.500 GeneticVariation disease BEFREE We find that the previously investigated single-nucleotide polymorphism rs4774 is associated with MS risk in cases carrying the HLA-DRB1*15 allele (P=0.01, odds ratio (OR): 1.21, 95% confidence interval (CI): 1.04-1.40) or the HLA-A*02 allele (P=0.01, OR: 1.33, 95% CI: 1.07-1.64) and that these associations are independent of the adjacent confirmed MS susceptibility gene CLEC16A. 24430172 2014
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis 		0.500 GeneticVariation disease BEFREE Multiple sclerosis-associated single-nucleotide polymorphisms in CLEC16A correlate with reduced SOCS1 and DEXI expression in the thymus. 23151489 2013
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis 		0.500 GeneticVariation disease GWASCAT Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis. 24076602 2013
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis 		0.500 Biomarker disease BEFREE Multiple sclerosis (MS) shares some risk genes with other disorders hallmarked by an autoimmune pathogenesis, most notably IL2RA and CLEC16A. 22130326 2012
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis 		0.500 Biomarker disease BEFREE In reciprocal experiments, a 20 kb fragment of intron 19 of CLEC16A, containing SNPs associated with T1D and MS, as well as with DEXI expression, interacted with the promotor region of DEXI but not with candidate DNA fragments containing other potential causal genes in the region, including CLEC16A. 21989056 2012
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis 		0.500 GeneticVariation disease GWASDB Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. 21833088 2011
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis 		0.500 GeneticVariation disease GWASCAT Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. 21833088 2011
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis 		0.500 GeneticVariation disease BEFREE All described base polymorphisms are mapping to one LD block of approximately 50 kb within intron 19 of the CLEC16A gene, suggesting a pivotal role of this region for susceptibility of MS and possibly also for other autoimmune diseases. 20849399 2011
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis 		0.500 GeneticVariation disease BEFREE Interrogating the complex role of chromosome 16p13.13 in multiple sclerosis susceptibility: independent genetic signals in the CIITA-CLEC16A-SOCS1 gene complex. 21653641 2011
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis 		0.500 GeneticVariation disease BEFREE Two other SNPs were nominally associated with MS in this dataset, namely CLEC16A rs 12708716 (p = 0.0082, OR = 1.478, 95% CI = 1.106-1.975) and CD226 rs763361 (p = 0.03971, OR = 1.353, CI = 1.014-1.805). 20952449 2011
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis 		0.500 Biomarker disease BEFREE To explore the CLEC16A association in MS in more detail, we genotyped 57 SNPs in 807 Norwegian MS patients and 1027 Norwegian controls. 21179112 2011
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis 		0.500 Biomarker disease BEFREE Furthermore, rs4774*C was associated with DRB1*1501+ MS when conditioned on the presence (OR = 1.67, 95% CI = 1.19-2.37, P = 1.9 x 10(-3)) and absence (OR = 1.49, 95% CI = 1.15-1.95, P = 2.3 x 10(-3)) of CLEC16A rs6498169*G, a putative MS risk allele adjacent to CIITA. 20211854 2010
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis 		0.500 Biomarker disease BEFREE For example, nucleotide variation in the interleukin 7 receptor (IL7RA), the interleukin 2 receptor (IL2RA), the CD58 and the c-type lectin domain family 16 member A (CLEC16A) genes has been consistently associated with MS in several populations. 20450971 2010
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis 		0.500 GeneticVariation disease BEFREE CLEC16A, a putative immunoreceptor, was recently established as a susceptibility locus for type I diabetes and multiple sclerosis. 20220768 2010
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis 		0.500 GeneticVariation disease BEFREE Associations of CLEC16A polymorphisms with T1D and MS were successfully replicated in a Spanish population. 19221398 2010
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis 		0.500 GeneticVariation disease BEFREE Recent association studies in multiple sclerosis (MS) have identified and replicated several single nucleotide polymorphism (SNP) susceptibility loci including CLEC16A, IL2RA, IL7R, RPL5, CD58, CD40 and chromosome 12q13-14 in addition to the well established allele HLA-DR15. 20368992 2010
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis 		0.500 GeneticVariation disease GWASCAT Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci. 19525953 2009
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis 		0.500 Biomarker disease LHGDN The expanding genetic overlap between multiple sclerosis and type I diabetes. 18987646 2009