FN1, fibronectin 1, 2335

N. diseases: 724; N. variants: 33
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Spondylometaphyseal dysplasia, 'corner fracture' type
0.700 Biomarker disease GENOMICS_ENGLAND "Novel fibronectin mutations and expansion of the phenotype in spondylometaphyseal dysplasia with ""corner fractures""." 30599297 2019
Spondylometaphyseal dysplasia, 'corner fracture' type
0.700 GeneticVariation disease UNIPROT "Mutations in Fibronectin Cause a Subtype of Spondylometaphyseal Dysplasia with ""Corner Fractures""." 29100092 2017
Spondylometaphyseal dysplasia, 'corner fracture' type
0.700 GeneticVariation disease CLINVAR "Mutations in Fibronectin Cause a Subtype of Spondylometaphyseal Dysplasia with ""Corner Fractures""." 29100092 2017
Spondylometaphyseal dysplasia, 'corner fracture' type
0.700 GermlineCausalMutation disease ORPHANET "Mutations in Fibronectin Cause a Subtype of Spondylometaphyseal Dysplasia with ""Corner Fractures""." 29100092 2017
Spondylometaphyseal dysplasia, 'corner fracture' type
0.700 Biomarker disease GENOMICS_ENGLAND "Mutations in Fibronectin Cause a Subtype of Spondylometaphyseal Dysplasia with ""Corner Fractures""." 29100092 2017
GLOMERULOPATHY WITH FIBRONECTIN DEPOSITS 2 (disorder)
0.700 Biomarker disease GENOMICS_ENGLAND Mutations in FN1 cause glomerulopathy with fibronectin deposits. 18268355 2008
GLOMERULOPATHY WITH FIBRONECTIN DEPOSITS 2 (disorder)
0.700 Biomarker disease GENOMICS_ENGLAND Mutations in FN1 cause glomerulopathy with fibronectin deposits. 18268355 2008
GLOMERULOPATHY WITH FIBRONECTIN DEPOSITS 2 (disorder)
0.700 GermlineCausalMutation disease ORPHANET Mutations in FN1 cause glomerulopathy with fibronectin deposits. 18268355 2008
GLOMERULOPATHY WITH FIBRONECTIN DEPOSITS 2 (disorder)
0.700 GeneticVariation disease UNIPROT Mutations in FN1 cause glomerulopathy with fibronectin deposits. 18268355 2008
Spondylometaphyseal dysplasia, 'corner fracture' type
0.700 CausalMutation disease CLINVAR
GLOMERULOPATHY WITH FIBRONECTIN DEPOSITS 2 (disorder)
0.700 Biomarker disease CTD_human
GLOMERULOPATHY WITH FIBRONECTIN DEPOSITS 2 (disorder)
0.700 CausalMutation disease CLINVAR
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.600 AlteredExpression disease BEFREE Extra domain A-containing fibronectin expression in Spin90-deficient fibroblasts mediates cancer-stroma interaction and promotes breast cancer progression. 31637720 2020
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.600 Biomarker disease BEFREE The extracellular matrix protein fibronectin (FN) facilitates tumorigenesis and the development of breast cancer. 31000696 2019
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.600 Biomarker disease BEFREE We recently showed that fibronectin (FN) leads to Tam resistance and selection of breast cancer stem cells. 31812165 2019
CUI: C0011881
Disease: Diabetic Nephropathy
Diabetic Nephropathy
0.600 AlteredExpression disease BEFREE In addition, intravenous administration of KLPPR resulted in excellent kidney-targeted distribution and low urinary excretion in mice with streptozocin-induced diabetic nephropathy (DN), lowered the parameters of urea nitrogen, serum creatinine and kidney index, as well as facilitated the recovery of renal physiological function in improving the levels of urinary creatinine and the creatinine clearance rate by suppressing secretion and accumulation of fibronectin and TGF-β1. 31534545 2019
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.600 AlteredExpression disease BEFREE Fibronectin levels were higher (P = 0.014) in patients infected with HCV than noninfected BC patients. 29285674 2018
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.600 AlteredExpression disease BEFREE Using publicly available clinical data, we observed that high FN expression was associated with poor prognosis in patients with breast cancer. 29628980 2018
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.600 Biomarker disease BEFREE Enhanced antitumor and anti-metastasis efficacy against aggressive breast cancer with a fibronectin-targeting liposomal doxorubicin. 29277681 2018
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.600 Biomarker disease BEFREE Autocrine Fibronectin Inhibits Breast Cancer Metastasis. 29934326 2018
CUI: C0011881
Disease: Diabetic Nephropathy
Diabetic Nephropathy
0.600 Biomarker disease BEFREE MiR-192 causes degradation of TGF-β1 and FN through targeting Egr1 and affects the progression of TIF and even DN. 30024615 2018
CUI: C0011881
Disease: Diabetic Nephropathy
Diabetic Nephropathy
0.600 AlteredExpression disease BEFREE Increased ColIV and FN levels may be partially responsible for the development of DN. 30233688 2018
CUI: C0011881
Disease: Diabetic Nephropathy
Diabetic Nephropathy
0.600 AlteredExpression disease BEFREE In view of the regulation of inflammation and fibrosis by myocardin-related transcription factor A (MRTF-A), we are highly concerned whether CK2α promotes AGEs-induced expressions of FN and ICAM-1 in glomerular mesangial cells via activation of MRTF-A, thus affecting the pathogenesis of DN. 29223351 2018
CUI: C0011881
Disease: Diabetic Nephropathy
Diabetic Nephropathy
0.600 AlteredExpression disease BEFREE The expression of FN, Col‑I, SCF and c‑kit mRNA and protein was upregulated in the tubulointerstitium of DKD model rats compared with the normal control rats, and tranilast inhibited the upregulated expression of these markers. 29568954 2018
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.600 AlteredExpression disease BEFREE In addition, overexpression of wild-type p53 markedly decreased the level of FN expression in p53-mutant breast cancer cells. 28765903 2017