|
Diabetes Mellitus
|
0.400 |
Biomarker
|
group |
BEFREE |
Our data indicated for the first time that TRB3-COP1-SIRT1 pathway played an important role in lipotoxicity leading to insulin resistance in hepatocytes, and suggested that COP1 could be a potential therapeutic choice for the treatment of diabetes mellitus, with lipotoxicity being the important pathomechanism.
|
31125554 |
2019 |
|
Diabetes Mellitus
|
0.400 |
Biomarker
|
group |
BEFREE |
Sirtuin 1 (SIRT1) activation reduces oxidative stress, inhibits inflammatory responses, and retards cellular senescence in endothelial cells in mouse models of diabetes.
|
30503839 |
2019 |
|
Diabetes Mellitus
|
0.400 |
Biomarker
|
group |
BEFREE |
These results offer a deeper understanding of the redox regulation of Sir2 in acetic acid resistance, which is relevant in some food and industrial biotechnology and also in the metabolism associated to calorie restriction, aging and pathologies such as diabetes.
|
31153040 |
2019 |
|
Diabetes Mellitus
|
0.400 |
AlteredExpression
|
group |
BEFREE |
As per the various reports reduction in SIRT1 expression in kidney tissue is key factor in the development of nephropathy in diabetes because its reduction in tissue is linked with excessive formation of ROS.
|
30641085 |
2019 |
|
Diabetes Mellitus
|
0.400 |
Biomarker
|
group |
BEFREE |
Activation of SirT1 mitigates metabolic perturbations associated with diabetes and obesity.
|
30877853 |
2019 |
|
Diabetes Mellitus
|
0.400 |
Biomarker
|
group |
BEFREE |
Therefore, in the present article, we discuss the role of SIRT1, SIRT3, and PA on β-cell function and on diabetes.
|
31557786 |
2019 |
|
Diabetes Mellitus
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Affecting the fetuin-A and SIRT1 levels introduces a new known mechanism of probiotic action in diabetes management.
|
30675190 |
2019 |
|
Diabetes Mellitus
|
0.400 |
Biomarker
|
group |
BEFREE |
The molecular cross talks linking autophagy and renoprotection through an intervention of 5'-AMP-activated protein kinase, mammalian target of rapamycin, and SIRT1 factors are also highlighted here, as in-depth exploration of these pathways may help in deriving therapeutic strategies for managing diabetes provoked end-stage renal disease.
|
31032918 |
2019 |
|
Diabetes Mellitus
|
0.400 |
Biomarker
|
group |
BEFREE |
The available evidence implies that sirtuin-1 has great potential as a clinical target for the prevention and treatment of diabetes.
|
30707256 |
2019 |
|
Diabetes Mellitus
|
0.400 |
AlteredExpression
|
group |
BEFREE |
In the present study, we hypothesized that melatonin attenuates renal I/R injury in diabetes by activating silent information regulator 2 associated protein 1 (SIRT1) expression and Nrf2/HO-1 signaling.
|
30578379 |
2019 |
|
Diabetes Mellitus
|
0.400 |
AlteredExpression
|
group |
BEFREE |
HT-NO not only decreased blood glucose and oxidative stress but also increased NO level and deacetylase Sirtuin 1 (SIRT1) expression in DM mice and high glucose (HG)-stimulated HUVECs.
|
30599900 |
2019 |
|
Diabetes Mellitus
|
0.400 |
Biomarker
|
group |
BEFREE |
Exploring the role of orexin B-sirtuin 1-HIF-1α in diabetes-mellitus induced vascular endothelial dysfunction and associated myocardial injury in rats.
|
31715188 |
2019 |
|
Diabetes Mellitus
|
0.400 |
Biomarker
|
group |
BEFREE |
These findings demonstrate the key role that SIRT1 plays in preventing calcification in a diabetic environment, through the inhibition of RUNX2 and senescence pathways, suggesting a downregulation of SIRT1 may be responsible for perpetuating vascular calcification in diabetes.
|
30696833 |
2019 |
|
Diabetes Mellitus
|
0.400 |
Biomarker
|
group |
BEFREE |
The novel SIRT1 activator SRT2104 attenuates diabetes-induced TACD.
|
30030567 |
2018 |
|
Diabetes Mellitus
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Expression Profile of Diabetes-Related Genes Associated with Leukocyte Sirtuin 1 Overexpression in Gestational Diabetes.
|
30513672 |
2018 |
|
Diabetes Mellitus
|
0.400 |
Biomarker
|
group |
BEFREE |
To determine the etiopathogenesis of diabetic cataract by studying changes in relative expressions of silent information regulator protein-1 (SIRT1) and P53 in rat lens epithelial cells (LECs) in experimentally induced diabetes mellitus (DM).
|
29199862 |
2018 |
|
Diabetes Mellitus
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Moreover, miR-211 was significantly up-regulated, while SIRT1 mRNA significantly down-regulated measuring by qRT-PCR, meanwhile, SIRT1 protein was significantly down-regulated in coincidence with SIRT1 mRNA detecting by western blot, and even aggravated associated with diabetes duration in diabetic retinal tissues of vivo experiment.
|
30333091 |
2018 |
|
Diabetes Mellitus
|
0.400 |
AlteredExpression
|
group |
BEFREE |
In vivo, myocardial levels of Sirt1 expression and activity were decreased in mice with STZ-induced DM.
|
30381241 |
2018 |
|
Diabetes Mellitus
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Both podocyte-specific SIRT1 overexpression and BT175 treatment attenuated diabetes-induced podocyte loss and reduced oxidative stress in glomeruli of OVE26 mice.
|
29477240 |
2018 |
|
Diabetes Mellitus
|
0.400 |
Biomarker
|
group |
BEFREE |
Inhibition of SIRT1 via EX-527 administration (100 nM) also reduced myotube diameter and area in DM conditions and resulted in lower gene expression of Myhc 1, 2 and 4 coding for 'intermediate' and 'faster' IIx, IIa and IIb protein isoforms, respectively.
|
29189984 |
2018 |
|
Diabetes Mellitus
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Hence, enhancing SIRT1 activity could be a potential therapeutic strategy to treat metabolic diseases such as diabetes.
|
29524414 |
2018 |
|
Diabetes Mellitus
|
0.400 |
Biomarker
|
group |
BEFREE |
With type 1 diabetes a disease that is characterised by metabolic dysregulation, we sought to assess the impact of SIRT1 activation in experimental, streptozotocin (STZ)-induced diabetes.
|
30228292 |
2018 |
|
Diabetes Mellitus
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Our data suggest that high concentration of glucose can induce neuronal apoptosis through downregulation of SIRT1 and increased acetylation of p53, which likely contribute to the development of cognitive impairment in diabetes.
|
29892266 |
2018 |
|
Diabetes Mellitus
|
0.400 |
Biomarker
|
group |
BEFREE |
Here, we evaluated different roles of sirtuins (SIRT1-SIRT7) in diabetes progression and described their involvement in metabolic pathways of skeletal muscle, adipose tissue and liver.
|
30559718 |
2018 |
|
Diabetes Mellitus
|
0.400 |
Biomarker
|
group |
BEFREE |
Those include development of novel technological platforms to examine microcirculatory beds, deeper understanding of patterns of microvascular derangement in diabetes, pathophysiology of nitric oxide synthesis and availability, nitrosative and oxidative stress in diabetes, premature senescence of endothelial cells and the role of sirtuin 1 and lysosomal dysfunction in this process, and the state of endothelial glycocalyx and endothelial progenitor cells in diabetes.
|
27852610 |
2017 |