SIRT1, sirtuin 1, 23411

N. diseases: 675; N. variants: 21
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Diabetes Mellitus, Non-Insulin-Dependent
0.600 Biomarker disease BEFREE Adiponectin/SIRT1 Axis Induces White Adipose Browning After Vertical Sleeve Gastrectomy of Obese Rats with Type 2 Diabetes. 31781938 2020
Diabetes Mellitus, Non-Insulin-Dependent
0.600 Biomarker disease BEFREE Sirtuin1 (SIRT1) is a crucial regulator of metabolism and it is implicated in the metabolic pathophysiology of several disorders inclusive of Type 2 diabetes and fatty liver disease (NAFLD). 31256424 2020
Diabetes Mellitus, Non-Insulin-Dependent
0.600 Biomarker disease BEFREE This study revealed an association of SIRT1 and WFS1 with T2D risk. 31759989 2020
Diabetes Mellitus, Non-Insulin-Dependent
0.600 GeneticVariation disease BEFREE Type 2 diabetes-associated polymorphisms correlate with SIRT1 and TGF-β1 gene expression. 31799723 2020
Diabetes Mellitus, Non-Insulin-Dependent
0.600 AlteredExpression disease BEFREE Significant down-regulations of the SIRT1 (3.1-fold, p = 0.0013) and PRKAB1 (3.5-fold, p = 0.0001) mRNA expression were observed in CAD<sup>+</sup> T2DM group in comparison with CAD<sup>-</sup>T2DM patients. 30935928 2019
Diabetes Mellitus, Non-Insulin-Dependent
0.600 AlteredExpression disease BEFREE miRNA expressions were determined by real-time polymerase chain reaction, and enzyme-linked immunosorbent assay was used to measure the SIRT1 protein levels in 25 T2DM patients and 25 controls. 31333735 2019
Diabetes Mellitus, Non-Insulin-Dependent
0.600 Biomarker disease BEFREE Our previous results demonstrated that sirtuin 1 (SIRT1), a nicotinamide adenine dinucleotide (NAD+)-dependent deacetylase, alleviates neuropathic pain in type 2 diabetes mellitus rats. 30649099 2019
Diabetes Mellitus, Non-Insulin-Dependent
0.600 AlteredExpression disease BEFREE Exercise-induced upregulation of SIRT1 attenuates inflammation and metabolic dysfunction, thereby alleviating the progression of diabetic nephropathy and hepatic steatosis in type 2 diabetes mellitus. 30988688 2019
Diabetes Mellitus, Non-Insulin-Dependent
0.600 Biomarker disease BEFREE The anti-nephritic activity of a polysaccharide from okra (Abelmoschus esculentus (L.) Moench) via modulation of AMPK-Sirt1-PGC-1α signaling axis mediated anti-oxidative in type 2 diabetes model mice. 31442509 2019
Diabetes Mellitus, Non-Insulin-Dependent
0.600 AlteredExpression disease BEFREE This study investigated the effects of type 1 diabetes (T1D), type 2 diabetes (T2D), and HT on the expression levels of SIRT1, SIRT3, and manganese superoxide dismutase (SOD2). 30736780 2019
Diabetes Mellitus, Non-Insulin-Dependent
0.600 Biomarker disease BEFREE Resveratrol upregulated PPAR-γ (P = 0.01) and sirtuin 1 (SIRT1) (P = 0.01) in the peripheral blood mononuclear cells (PBMCs) of T2DM patients with CHD. 31486447 2019
Diabetes Mellitus, Non-Insulin-Dependent
0.600 Biomarker disease BEFREE In the present study, the ability of a sirtuin‑1 (SIRT1) agonist, SRT1720, to reduce cognitive decline in type 2 diabetes mellitus (T2DM) was investigated. 30483738 2019
Diabetes Mellitus, Non-Insulin-Dependent
0.600 Biomarker disease BEFREE It has been suggested that SIRT1 activators may have a protective role against type 2 diabetes, the aging process, and inflammation. 31377446 2019
Diabetes Mellitus, Non-Insulin-Dependent
0.600 Biomarker disease BEFREE Therefore, SIRT1 and 3 activators have been proposed to prevent and counteract metabolic age-related diseases, such as type 2 diabetes mellitus (T2DM). 31557786 2019
Diabetes Mellitus, Non-Insulin-Dependent
0.600 Biomarker disease BEFREE MiR-138-5p affects insulin resistance to regulate type 2 diabetes progression through inducing autophagy in HepG2 cells by regulating SIRT1. 30442237 2018
Diabetes Mellitus, Non-Insulin-Dependent
0.600 Biomarker disease BEFREE In conclusion, Biochanin A has significant effect in type 2 diabetes mellitus which might be linked to its effects on SIRT1. 30257324 2018
Diabetes Mellitus, Non-Insulin-Dependent
0.600 AlteredExpression disease BEFREE Relative expression of HIF1α and Sirt1 in T2DM patients was determined via real-time PCR. 30196291 2018
Diabetes Mellitus, Non-Insulin-Dependent
0.600 AlteredExpression disease BEFREE It can be concluded that formononetin treatment reduces insulin resistance and attenuate hyperglycemia in type 2 diabetes which may be due to increasing expression of SIRT1 in pancreatic tissues. 30072892 2018
Diabetes Mellitus, Non-Insulin-Dependent
0.600 Biomarker disease BEFREE Although compelling evidence indicates that Sirtuin 1 (SIRT1) plays a prominent role in type 2 diabetes, its relationship with gestational diabetes (GDM) remains elusive. 30513672 2018
Diabetes Mellitus, Non-Insulin-Dependent
0.600 GeneticVariation disease BEFREE The present study aimed to explore the influence of sirtuin 1 (SIRT1) polymorphisms (rs12778366 and rs3758391) on diabetic foot (DF) susceptibility and severity in patients with type 2 diabetes mellitus (T2DM).This case-control study recruited 142 patients with DF, 148 patients with T2DM, and 148 healthy controls. 29995800 2018
Diabetes Mellitus, Non-Insulin-Dependent
0.600 Biomarker disease BEFREE We suggest that this metabolic improvement might be related to SIRT1 and AMPK pathway in T2DM. 30474134 2018
Diabetes Mellitus, Non-Insulin-Dependent
0.600 Biomarker disease BEFREE We provide new knowledge on H3K56ac and SIRT-1 association in T2DM. 29330620 2018
Diabetes Mellitus, Non-Insulin-Dependent
0.600 AlteredExpression disease BEFREE SS-31 also increased mitochondrial membrane potential, glutathione content, SIRT1 levels and leukocyte rolling velocity and reduced rolling flux and adhesion in T2D patients. 30367115 2018
Diabetes Mellitus, Non-Insulin-Dependent
0.600 Biomarker disease BEFREE Due to its diverse role in metabolisms, SIRT1 has emerged as a potential therapeutic target in many human disorders such as type II diabetes, cardiovascular and neurodegenerative diseases, and cancer. 30448921 2018
Diabetes Mellitus, Non-Insulin-Dependent
0.600 Biomarker disease BEFREE The human Sirtuin isoforms, SIRT1-7, are considered attractive therapeutic targets for aging-related diseases, such as type 2 diabetes, inflammatory diseases and neurodegenerative disorders. 29577959 2018