OTP, orthopedia homeobox, 23440

N. diseases: 22; N. variants: 0
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0007095
Disease: Carcinoid Tumor
Carcinoid Tumor
0.050 AlteredExpression phenotype BEFREE We identify therapeutically relevant molecular groups of pulmonary carcinoids, suggesting DLL3 and the immune system as candidate therapeutic targets; we confirm the value of OTP expression levels for the prognosis and diagnosis of these diseases, and we unveil the group of supra-carcinoids. 31431620 2019
CUI: C0007095
Disease: Carcinoid Tumor
Carcinoid Tumor
0.050 AlteredExpression phenotype BEFREE Expression of OTP appears to correlate with poorer prognosis in pulmonary carcinoids; however, its expression patterns in other NE/neuroepithelial tumors need further investigation. 30523500 2019
CUI: C0007095
Disease: Carcinoid Tumor
Carcinoid Tumor
0.050 AlteredExpression phenotype BEFREE This review addresses the current clinical value of OTP and the possible molecular mechanisms regulating OTP expression and function in pulmonary carcinoids. 31597385 2019
CUI: C0007095
Disease: Carcinoid Tumor
Carcinoid Tumor
0.050 AlteredExpression phenotype BEFREE Prognostic Significance of CD44 and Orthopedia Homeobox Protein (OTP) Expression in Pulmonary Carcinoid Tumours. 27873160 2017
CUI: C0007095
Disease: Carcinoid Tumor
Carcinoid Tumor
0.050 AlteredExpression phenotype BEFREE Low mRNA expression levels of CD44 (P = 1.8e(-5)) and OTP (P = 0.00054), and high levels of RET (P = 0.025), were strongly associated with a low 20-year survival of carcinoid patients. 23444222 2013
CUI: C0334299
Disease: Carcinoid tumor no ICD-O subtype
Carcinoid tumor no ICD-O subtype
0.030 Biomarker phenotype BEFREE In future clinical practice OTP may enable clinicians to reduce the diagnostic burden and related distress and reduce costs of long-term radiological assessments in patients with a pulmonary carcinoid. 31597385 2019
CUI: C0334299
Disease: Carcinoid tumor no ICD-O subtype
Carcinoid tumor no ICD-O subtype
0.030 Biomarker phenotype BEFREE CD44 and orthopedia homeobox protein (OTP) expressions have shown to be predictive of overall survival in pulmonary carcinoid (PC) tumours. 27873160 2017
CUI: C0334299
Disease: Carcinoid tumor no ICD-O subtype
Carcinoid tumor no ICD-O subtype
0.030 AlteredExpression phenotype BEFREE Low mRNA expression levels of CD44 (P = 1.8e(-5)) and OTP (P = 0.00054), and high levels of RET (P = 0.025), were strongly associated with a low 20-year survival of carcinoid patients. 23444222 2013
CUI: C0206754
Disease: Neuroendocrine Tumors
Neuroendocrine Tumors
0.020 Biomarker group BEFREE Orthopedia Homeobox (OTP) in Pulmonary Neuroendocrine Tumors: The Diagnostic Value and Possible Molecular Interactions. 31597385 2019
CUI: C0206754
Disease: Neuroendocrine Tumors
Neuroendocrine Tumors
0.020 Biomarker group BEFREE Orthopedia homeobox protein (OTP) has a well-defined role in embryonic neurodevelopment and has also been described as a prognostic marker in lung neuroendocrine tumors (NET). 30284410 2018
CUI: C0007112
Disease: Adenocarcinoma of prostate
Adenocarcinoma of prostate
0.010 AlteredExpression disease BEFREE Diffuse expression of OTP was detected in 50% of prostate adenocarcinoma with NE differentiation and 100% neuroendocrine carcinoma of the ovary. 30523500 2019
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.010 Biomarker group BEFREE Expression of Insulinoma-Associated Protein 1 (INSM1) and Orthopedia Homeobox (OTP) in Tumors with Neuroendocrine Differentiation at Rare Sites. 30523500 2019
CUI: C0206695
Disease: Carcinoma, Neuroendocrine
Carcinoma, Neuroendocrine
0.010 AlteredExpression disease BEFREE Diffuse expression of OTP was detected in 50% of prostate adenocarcinoma with NE differentiation and 100% neuroendocrine carcinoma of the ovary. 30523500 2019
CUI: C0206715
Disease: Neoplasms, Neuroepithelial
Neoplasms, Neuroepithelial
0.010 AlteredExpression group BEFREE Expression of OTP appears to correlate with poorer prognosis in pulmonary carcinoids; however, its expression patterns in other NE/neuroepithelial tumors need further investigation. 30523500 2019
CUI: C0022595
Disease: Keratosis Follicularis
Keratosis Follicularis
0.010 Biomarker disease BEFREE Our systematic study of dynamical decoupling (DD) as a function of temperature (at 40, 80 K and RT), spin concentration, deuteration of nitroxide and/or OTP matrix and DD scheme for 1 to 5 refocusing pulses reveals that DD significantly prolongs phase memory times with respect to Hahn echo relaxation at 40 K, which we discuss in an SSE framework. 29261205 2018
CUI: C0220726
Disease: Diastrophic dysplasia
Diastrophic dysplasia
0.010 Biomarker disease BEFREE Our systematic study of dynamical decoupling (DD) as a function of temperature (at 40, 80 K and RT), spin concentration, deuteration of nitroxide and/or OTP matrix and DD scheme for 1 to 5 refocusing pulses reveals that DD significantly prolongs phase memory times with respect to Hahn echo relaxation at 40 K, which we discuss in an SSE framework. 29261205 2018
CUI: C0003467
Disease: Anxiety
Anxiety
0.010 Biomarker disease BEFREE Disruption of the homeodomain transcription factor orthopedia homeobox (Otp) is associated with obesity and anxiety. 29107289 2017
CUI: C0003469
Disease: Anxiety Disorders
Anxiety Disorders
0.010 Biomarker group BEFREE Disruption of the homeodomain transcription factor orthopedia homeobox (Otp) is associated with obesity and anxiety. 29107289 2017
CUI: C0028754
Disease: Obesity
Obesity
0.010 GeneticVariation disease BEFREE We sequenced OTP in 2548 people with severe early-onset obesity and found a rare heterozygous loss of function variant in the homeodomain (Q153R) in a patient who also had features of attention deficit disorder. 29107289 2017
CUI: C0041671
Disease: Attention Deficit Disorder
Attention Deficit Disorder
0.010 GeneticVariation disease BEFREE We sequenced OTP in 2548 people with severe early-onset obesity and found a rare heterozygous loss of function variant in the homeodomain (Q153R) in a patient who also had features of attention deficit disorder. 29107289 2017
Attention-Deficit/Hyperactivity Disorder, Predominantly Inattentive Type
0.010 GeneticVariation disease BEFREE We sequenced OTP in 2548 people with severe early-onset obesity and found a rare heterozygous loss of function variant in the homeodomain (Q153R) in a patient who also had features of attention deficit disorder. 29107289 2017
Attention deficit hyperactivity disorder
0.010 GeneticVariation disease BEFREE We sequenced OTP in 2548 people with severe early-onset obesity and found a rare heterozygous loss of function variant in the homeodomain (Q153R) in a patient who also had features of attention deficit disorder. 29107289 2017
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.010 PosttranslationalModification disease BEFREE In conclusion, we successfully identified a novel gene OTP frequently methylated in breast cancer by genome-wide screening. 22366991 2012
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.010 Biomarker group BEFREE Our results suggest that the OTP gene may play a crucial role in breast carcinogenesis, although further clinical validation will be needed to evaluate the potential application of OTP in the early detection of breast cancer. 22366991 2012
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.010 Biomarker phenotype BEFREE Our results suggest that the OTP gene may play a crucial role in breast carcinogenesis, although further clinical validation will be needed to evaluate the potential application of OTP in the early detection of breast cancer. 22366991 2012