Carcinoid Tumor
|
0.050 |
AlteredExpression
|
phenotype |
BEFREE |
We identify therapeutically relevant molecular groups of pulmonary carcinoids, suggesting DLL3 and the immune system as candidate therapeutic targets; we confirm the value of OTP expression levels for the prognosis and diagnosis of these diseases, and we unveil the group of supra-carcinoids.
|
31431620 |
2019 |
Carcinoid Tumor
|
0.050 |
AlteredExpression
|
phenotype |
BEFREE |
Expression of OTP appears to correlate with poorer prognosis in pulmonary carcinoids; however, its expression patterns in other NE/neuroepithelial tumors need further investigation.
|
30523500 |
2019 |
Carcinoid Tumor
|
0.050 |
AlteredExpression
|
phenotype |
BEFREE |
This review addresses the current clinical value of OTP and the possible molecular mechanisms regulating OTP expression and function in pulmonary carcinoids.
|
31597385 |
2019 |
Carcinoid Tumor
|
0.050 |
AlteredExpression
|
phenotype |
BEFREE |
Prognostic Significance of CD44 and Orthopedia Homeobox Protein (OTP) Expression in Pulmonary Carcinoid Tumours.
|
27873160 |
2017 |
Carcinoid Tumor
|
0.050 |
AlteredExpression
|
phenotype |
BEFREE |
Low mRNA expression levels of CD44 (P = 1.8e(-5)) and OTP (P = 0.00054), and high levels of RET (P = 0.025), were strongly associated with a low 20-year survival of carcinoid patients.
|
23444222 |
2013 |
Carcinoid tumor no ICD-O subtype
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
In future clinical practice OTP may enable clinicians to reduce the diagnostic burden and related distress and reduce costs of long-term radiological assessments in patients with a pulmonary carcinoid.
|
31597385 |
2019 |
Carcinoid tumor no ICD-O subtype
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
CD44 and orthopedia homeobox protein (OTP) expressions have shown to be predictive of overall survival in pulmonary carcinoid (PC) tumours.
|
27873160 |
2017 |
Carcinoid tumor no ICD-O subtype
|
0.030 |
AlteredExpression
|
phenotype |
BEFREE |
Low mRNA expression levels of CD44 (P = 1.8e(-5)) and OTP (P = 0.00054), and high levels of RET (P = 0.025), were strongly associated with a low 20-year survival of carcinoid patients.
|
23444222 |
2013 |
Neuroendocrine Tumors
|
0.020 |
Biomarker
|
group |
BEFREE |
Orthopedia Homeobox (OTP) in Pulmonary Neuroendocrine Tumors: The Diagnostic Value and Possible Molecular Interactions.
|
31597385 |
2019 |
Neuroendocrine Tumors
|
0.020 |
Biomarker
|
group |
BEFREE |
Orthopedia homeobox protein (OTP) has a well-defined role in embryonic neurodevelopment and has also been described as a prognostic marker in lung neuroendocrine tumors (NET).
|
30284410 |
2018 |
Adenocarcinoma of prostate
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Diffuse expression of OTP was detected in 50% of prostate adenocarcinoma with NE differentiation and 100% neuroendocrine carcinoma of the ovary.
|
30523500 |
2019 |
Neoplasms
|
0.010 |
Biomarker
|
group |
BEFREE |
Expression of Insulinoma-Associated Protein 1 (INSM1) and Orthopedia Homeobox (OTP) in Tumors with Neuroendocrine Differentiation at Rare Sites.
|
30523500 |
2019 |
Carcinoma, Neuroendocrine
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Diffuse expression of OTP was detected in 50% of prostate adenocarcinoma with NE differentiation and 100% neuroendocrine carcinoma of the ovary.
|
30523500 |
2019 |
Neoplasms, Neuroepithelial
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Expression of OTP appears to correlate with poorer prognosis in pulmonary carcinoids; however, its expression patterns in other NE/neuroepithelial tumors need further investigation.
|
30523500 |
2019 |
Keratosis Follicularis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our systematic study of dynamical decoupling (DD) as a function of temperature (at 40, 80 K and RT), spin concentration, deuteration of nitroxide and/or OTP matrix and DD scheme for 1 to 5 refocusing pulses reveals that DD significantly prolongs phase memory times with respect to Hahn echo relaxation at 40 K, which we discuss in an SSE framework.
|
29261205 |
2018 |
Diastrophic dysplasia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our systematic study of dynamical decoupling (DD) as a function of temperature (at 40, 80 K and RT), spin concentration, deuteration of nitroxide and/or OTP matrix and DD scheme for 1 to 5 refocusing pulses reveals that DD significantly prolongs phase memory times with respect to Hahn echo relaxation at 40 K, which we discuss in an SSE framework.
|
29261205 |
2018 |
Anxiety
|
0.010 |
Biomarker
|
disease |
BEFREE |
Disruption of the homeodomain transcription factor orthopedia homeobox (Otp) is associated with obesity and anxiety.
|
29107289 |
2017 |
Anxiety Disorders
|
0.010 |
Biomarker
|
group |
BEFREE |
Disruption of the homeodomain transcription factor orthopedia homeobox (Otp) is associated with obesity and anxiety.
|
29107289 |
2017 |
Obesity
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
We sequenced OTP in 2548 people with severe early-onset obesity and found a rare heterozygous loss of function variant in the homeodomain (Q153R) in a patient who also had features of attention deficit disorder.
|
29107289 |
2017 |
Attention Deficit Disorder
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
We sequenced OTP in 2548 people with severe early-onset obesity and found a rare heterozygous loss of function variant in the homeodomain (Q153R) in a patient who also had features of attention deficit disorder.
|
29107289 |
2017 |
Attention-Deficit/Hyperactivity Disorder, Predominantly Inattentive Type
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
We sequenced OTP in 2548 people with severe early-onset obesity and found a rare heterozygous loss of function variant in the homeodomain (Q153R) in a patient who also had features of attention deficit disorder.
|
29107289 |
2017 |
Attention deficit hyperactivity disorder
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
We sequenced OTP in 2548 people with severe early-onset obesity and found a rare heterozygous loss of function variant in the homeodomain (Q153R) in a patient who also had features of attention deficit disorder.
|
29107289 |
2017 |
Malignant neoplasm of breast
|
0.010 |
PosttranslationalModification
|
disease |
BEFREE |
In conclusion, we successfully identified a novel gene OTP frequently methylated in breast cancer by genome-wide screening.
|
22366991 |
2012 |
Malignant Neoplasms
|
0.010 |
Biomarker
|
group |
BEFREE |
Our results suggest that the OTP gene may play a crucial role in breast carcinogenesis, although further clinical validation will be needed to evaluate the potential application of OTP in the early detection of breast cancer.
|
22366991 |
2012 |
Carcinogenesis
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Our results suggest that the OTP gene may play a crucial role in breast carcinogenesis, although further clinical validation will be needed to evaluate the potential application of OTP in the early detection of breast cancer.
|
22366991 |
2012 |