FOLR1, folate receptor alpha, 2348

N. diseases: 174; N. variants: 8
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0919267
Disease: ovarian neoplasm
ovarian neoplasm
0.400 Biomarker disease BEFREE New tumor markers, such as PRSS8, FOLR1, KLK6/7, GSTT1, and miRNAs, are getting ahead and are worth noting for early detection of ovarian cancer. 31081307 2019
CUI: C0919267
Disease: ovarian neoplasm
ovarian neoplasm
0.400 AlteredExpression disease BEFREE (2) FOLR1 expression was decreased in platinum drug-resistant ovarian tumors compared to sensitive tumors (P < 0.01). 29433550 2018
CUI: C0919267
Disease: ovarian neoplasm
ovarian neoplasm
0.400 Biomarker disease BEFREE Our previous identification of degenerate HLA-class II epitopes from human FR led to the development of a broad coverage epitope pool potentially useful in augmenting antigen-specific immune responses in most patients.<b>Patients and Methods:</b> We conducted a phase I clinical trial testing safety and immunogenicity of this vaccine, enrolling patients with ovarian cancer or breast cancer who completed conventional treatment and who showed no evidence of disease. 29545464 2018
CUI: C0919267
Disease: ovarian neoplasm
ovarian neoplasm
0.400 Biomarker disease BEFREE A Single-Agent Dual-Specificity Targeting of FOLR1 and DR5 as an Effective Strategy for Ovarian Cancer. 30107179 2018
CUI: C0919267
Disease: ovarian neoplasm
ovarian neoplasm
0.400 AlteredExpression disease BEFREE Folate binding protein(FBP) is an immunogenic protein over-expressed in endometrial(EC) and ovarian cancer(OC). 27852036 2017
CUI: C0919267
Disease: ovarian neoplasm
ovarian neoplasm
0.400 AlteredExpression disease BEFREE Therefore, FRα-targeted lipoplexes with therapeutic gene expression regulated by an hTERT promoter might be a promising gene therapy agent and a potential translational candidate for the clinical treatment of ovarian cancer. 27026065 2016
CUI: C0919267
Disease: ovarian neoplasm
ovarian neoplasm
0.400 AlteredExpression disease BEFREE The objective of this study was to measure the levels of FOLR1 and Dkk-3 in the serum of patients with ovarian cancer, benign gynecological conditions and healthy women. 23528302 2013
CUI: C0919267
Disease: ovarian neoplasm
ovarian neoplasm
0.400 Biomarker disease BEFREE Folate receptor alpha (FRalpha) is overexpressed on ovarian cancer cells and is a promising molecular target for ovarian cancer gene therapy, but there was still no related report. 23802413 2013
CUI: C0919267
Disease: ovarian neoplasm
ovarian neoplasm
0.400 Biomarker disease BEFREE The chimeric antibody, MOv18 IgE, against the human ovarian carcinoma antigen, folate receptor α (FRα), is more effective than its IgG1 counterpart in xenograft models of ovarian cancer. 21569129 2011
CUI: C0919267
Disease: ovarian neoplasm
ovarian neoplasm
0.400 Therapeutic disease CTD_human Vaccination with dendritic cells transfected with mRNA-encoded folate-receptor-alpha for relapsed metastatic ovarian cancer. 17466904 2007
CUI: C0919267
Disease: ovarian neoplasm
ovarian neoplasm
0.400 Biomarker disease BEFREE Folate-binding protein is a marker for ovarian cancer. 1717147 1991