Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Ki-1+ Anaplastic Large Cell Lymphoma
0.700 CausalMutation disease CGI
Ki-1+ Anaplastic Large Cell Lymphoma
0.700 SomaticCausalMutation disease ORPHANET
Ki-1+ Anaplastic Large Cell Lymphoma
0.700 Biomarker disease BEFREE Detection of NPM-ALK DNA rearrangement in CD30 positive anaplastic large cell lymphoma. 7772531 1995
Ki-1+ Anaplastic Large Cell Lymphoma
0.700 Biomarker disease BEFREE These data indicate that NPM/ALK fusion transcripts occur in a high percentage of classical nodal ALCL (65%). 7662979 1995
Ki-1+ Anaplastic Large Cell Lymphoma
0.700 Biomarker disease BEFREE Anaplastic large cell lymphomas expressing the novel chimeric protein p80NPM/ALK: a distinct clinicopathologic entity. 7655022 1995
Ki-1+ Anaplastic Large Cell Lymphoma
0.700 GeneticVariation disease BEFREE The NPM/ALK-expressing cases were not confined to NHLs with anaplastic morphology and included 15 ALCLs, 6 immunoblastic lymphomas, and 10 diffuse large-cell lymphomas. 7780128 1995
Ki-1+ Anaplastic Large Cell Lymphoma
0.700 Biomarker disease BEFREE ALK gene products in anaplastic large cell lymphomas and Hodgkin's disease. 7655001 1995
Ki-1+ Anaplastic Large Cell Lymphoma
0.700 GeneticVariation disease BEFREE Our data show that NPM-ALK gene transcripts are identified in a subpopulation of ALCL, almost exclusively in T or null cell in origin, and in rare cases of HD. 8562933 1996
Ki-1+ Anaplastic Large Cell Lymphoma
0.700 Biomarker disease BEFREE NPM/ALK gene fusion transcripts identify a distinct subgroup of null type Ki-1 positive anaplastic large cell lymphomas. 8616079 1996
Ki-1+ Anaplastic Large Cell Lymphoma
0.700 GeneticVariation disease BEFREE As all seven bona fide HD cell lines were NPM-ALK-negative, these results do not support the notion that the t(2;5) represents a chromosomal aberration common to both ALCL and HD. 8558920 1996
Ki-1+ Anaplastic Large Cell Lymphoma
0.700 GeneticVariation disease BEFREE Molecular variant of the NPM-ALK rearrangement of Ki-1 lymphoma involving a cryptic ALK splice site. 8721682 1996
Ki-1+ Anaplastic Large Cell Lymphoma
0.700 GeneticVariation disease BEFREE Further studies are needed to determine the prognostic significance of the NPM-ALK rearrangement, to determine whether its detection can aid in the differential diagnosis between ALCL. 8781434 1996
Ki-1+ Anaplastic Large Cell Lymphoma
0.700 GeneticVariation disease BEFREE The expected 177 bp product indicative of the NPM-ALK rearrangement was identified in Karpas 299 and SUDHL-1 cell lines and in two out of eight ALCLs. 8683377 1996
Ki-1+ Anaplastic Large Cell Lymphoma
0.700 AlteredExpression disease BEFREE Frequent expression of the NPM-ALK chimeric fusion protein in anaplastic large-cell lymphoma, lympho-histiocytic type. 9094977 1997
Ki-1+ Anaplastic Large Cell Lymphoma
0.700 GeneticVariation disease BEFREE There was no evidence by cytogenetics (one case analyzed) or reverse transcriptase-PCR (three cases tested) of the 2; 5 translocation or the resultant NPM-ALK gene, as is commonly found in ALCL. 9057627 1997
Ki-1+ Anaplastic Large Cell Lymphoma
0.700 Biomarker disease BEFREE Anaplastic large cell lymphomas expressing the novel chimeric protein p80NPM/ALK: a distinct clinicopathologic entity. 9209450 1997
Ki-1+ Anaplastic Large Cell Lymphoma
0.700 Biomarker disease BEFREE The clinicopathological features of anaplastic large cell lymphomas expressing p80NPM/ALK. 9021682 1997
Ki-1+ Anaplastic Large Cell Lymphoma
0.700 GeneticVariation disease BEFREE The monoclonal antibody ALK1 identifies a distinct morphological subtype of anaplastic large cell lymphoma associated with 2p23/ALK rearrangements. 9250148 1997
Ki-1+ Anaplastic Large Cell Lymphoma
0.700 GeneticVariation disease BEFREE The t(2;5)(p23;q35) translocation, associated with anaplastic large-cell lymphoma (ALCL), results in the production of the nucleolar protein nucleophosmin-anaplastic lymphoma kinase (NPM-ALK) protein. 9028963 1997
Ki-1+ Anaplastic Large Cell Lymphoma
0.700 GeneticVariation disease BEFREE The ALK gene was initially identified through its involvement in the t(2;5)(p23;q35) found most commonly in anaplastic large cell lymphoma. 9216718 1997
Ki-1+ Anaplastic Large Cell Lymphoma
0.700 GeneticVariation disease BEFREE Detection of the NPM-ALK genomic rearrangement of Ki-1 lymphoma and isolation of the involved NPM and ALK introns. 8866227 1997
Ki-1+ Anaplastic Large Cell Lymphoma
0.700 GeneticVariation disease BEFREE The t(2;5) (p23;q35) translocation, resulting in the fusion of the nucleophosmin (NPM) gene and the anaplastic lymphoma kinase (ALK) gene, is associated with primary CD30+ ALCL. 9274957 1997
Ki-1+ Anaplastic Large Cell Lymphoma
0.700 Biomarker disease BEFREE A characteristic chromosomal translocation has been identified in ALCL of T-or null-cell lineage which juxtaposes a novel tyrosine kinase (anaplastic lymphoma kinase, ALK) located at 2p23 with the nucleophosmin gene (NPM) at 5q35. 9209644 1997
Ki-1+ Anaplastic Large Cell Lymphoma
0.700 GeneticVariation disease BEFREE More than 60% of anaplastic large-cell lymphomas (Ki-1 lymphoma) are associated with a t(2;5)(p23;q35) translocation that produces an 80 kDa hyperphosphorylated chimeric protein (p80) derived from the fusion of the anaplastic lymphoma kinase (ALK) with nucleophosmin (NPM). 9337149 1997
Ki-1+ Anaplastic Large Cell Lymphoma
0.700 Biomarker disease BEFREE The diagnosis of ALCL was based on immuno-morphological features and all the cases but 2 were investigated using ALK1 antibody directed to the NPM/ALK protein associated with the 2;5 translocation. 9808552 1998